Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7VJB6 (PGK_HELHP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:HH_0327
OrganismHelicobacter hepaticus (strain ATCC 51449 / 3B1) [Complete proteome] [HAMAP]
Taxonomic identifier235279 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145949

Regions

Nucleotide binding358 – 3614ATP By similarity
Region30 – 323Substrate binding By similarity
Region70 – 734Substrate binding By similarity

Sites

Binding site461Substrate By similarity
Binding site1261Substrate By similarity
Binding site1591Substrate By similarity
Binding site2101ATP By similarity
Binding site3321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VJB6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7C5BDBF24113F8D6

FASTA40244,464
        10         20         30         40         50         60 
MKETGIELMK NTKSVRDIDV KDKRVLIRVD FNVPMDEDFD ISDDTRIREA LPTINYCIDN 

        70         80         90        100        110        120 
HAQNIVLVSH LGRPKGRNAE FSLKHVLKRV ERLLGRDIAF AETIENVENL QQQSKSGSVI 

       130        140        150        160        170        180 
LLENIRFYEG EEKNDEELST KLASICDVYI NDAFGTSHRA HSSTCGIAKY AKECVAGLLL 

       190        200        210        220        230        240 
KKEIDSFAKA MANPLKPVLL IVGGSKVSSK LALLYNILDV VDKIIIGGAM SNTFLKARGF 

       250        260        270        280        290        300 
DMQKSLVEDD LVSEARKILD KAKEKKVKIY LPVDVVSTDD IKEHRHIKIT PAQDIPEGFM 

       310        320        330        340        350        360 
AVDMGPATSK LFSEVVRDSQ TIIWNGPLGI YEIQAFSRGT FNLAHAVSDT YAFSLIGGGD 

       370        380        390        400 
TADAIDKAGE RDNMSFISTG GGASLELLEG KILPAFEVLE RK 

« Hide

References

[1]"The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus."
Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M., Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R., Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B. expand/collapse author list , Shen Z., Weber J., Frosch M., Fox J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51449 / 3B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017125 Genomic DNA. Translation: AAP76924.1.
RefSeqNP_859858.1. NC_004917.1.

3D structure databases

ProteinModelPortalQ7VJB6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING235279.HH0327.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP76924; AAP76924; HH_0327.
GeneID1493381.
KEGGhhe:HH0327.
PATRIC20588088. VBIHelHep90276_0332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAAGHPVGK.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycHHEP235279:GHUA-334-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_HELHP
AccessionPrimary (citable) accession number: Q7VJB6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways