Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7VIY7

- SYL_HELHP

UniProt

Q7VIY7 - SYL_HELHP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei599 – 5991ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHHEP235279:GHUA-482-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:HH_0465
    OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
    Taxonomic identifieri235279 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000002495: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830Leucine--tRNA ligasePRO_0000152025Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi235279.HH0465.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VIY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi596 – 6005"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VIY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQERKYNPKD IESKWQQFWT EHKSFEPFDI DIATSDSMKK KYILSMFPYP    50
    SGAIHMGHVR NYCIGDALAR NYRQNGYNVL HPMGWDAFGM PAENAAIKHK 100
    THPKTWTYSN IDTMRKELAT LGLSFSKERE FATSDAIYTR FEQEFFIKMW 150
    ERGLIYRKEA YLNWCPKDKT ILANEQVIEG KCWRCDTPVV QKQMFQYYIK 200
    ITDYADELLE CLNKLEGHWP SQVLSMQRNW IGKSKGLSFT FDFSVDSLQK 250
    LGNGKVKLEV FTTRPDTIYG VTYCAVAPEH PIVQQLIENK SLDESVIKSI 300
    EAIKNTTARA RAMSEKVGFD LGVYVIHPLT QEKLPVWVAN FVLMDYGSGA 350
    VMSVPMHDER DFEFAKTYAL PFKCVLTKEI DGEEPTQEIC AAYEEGFLIN 400
    SGEFSGMSSS QAKERIIAHF ENASIGKGIT NYRLRDWGVS RQRYWGAPIP 450
    MVHCQSCGIV PEKIENLPIT LPEDVVIDGE GNPLDKHLVW KDCLCPKCGK 500
    KAQRESDTMD TFIQSSWYFL RYSTPRKLWE KQAFDKESLT YWLNVDEYIG 550
    GIEHAILHLL YARFWTKVLR DLGYIEIDEP FANLLTQGMV LKDGAKMSKS 600
    KGNIVNPNEL IAHYGADTAR LFVLFAAPPT RELEWNDKAV EGAHRFLKRL 650
    WERAEHIESC TQKPHINHKT LQKNEQYARQ KVYEALQKSN EIFSKKQSGY 700
    AFNTLIAASM EAFNALNEQE NPLVWTEGYF VLLHILEPIV PHICWELSEQ 750
    YFRRCNFAPL SVDKDALTKE SVIYAITING KKRAEVEMPL GLSKEEIIIQ 800
    AKESVPKWLE GVEILKEIIV PNKLVNLVVK 830
    Length:830
    Mass (Da):95,681
    Last modified:October 1, 2003 - v1
    Checksum:iCC08CB32DA94E06F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017125 Genomic DNA. Translation: AAP77062.1.
    RefSeqiNP_859996.1. NC_004917.1.

    Genome annotation databases

    EnsemblBacteriaiAAP77062; AAP77062; HH_0465.
    GeneIDi1493519.
    KEGGihhe:HH0465.
    PATRICi20588384. VBIHelHep90276_0470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017125 Genomic DNA. Translation: AAP77062.1 .
    RefSeqi NP_859996.1. NC_004917.1.

    3D structure databases

    ProteinModelPortali Q7VIY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 235279.HH0465.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP77062 ; AAP77062 ; HH_0465 .
    GeneIDi 1493519.
    KEGGi hhe:HH0465.
    PATRICi 20588384. VBIHelHep90276_0470.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HHEP235279:GHUA-482-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51449 / 3B1.

    Entry informationi

    Entry nameiSYL_HELHP
    AccessioniPrimary (citable) accession number: Q7VIY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3