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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei599 – 5991ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HH_0465
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Leucine--tRNA ligasePRO_0000152025Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH0465.

Structurei

3D structure databases

ProteinModelPortaliQ7VIY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi596 – 6005"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VIY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQERKYNPKD IESKWQQFWT EHKSFEPFDI DIATSDSMKK KYILSMFPYP
60 70 80 90 100
SGAIHMGHVR NYCIGDALAR NYRQNGYNVL HPMGWDAFGM PAENAAIKHK
110 120 130 140 150
THPKTWTYSN IDTMRKELAT LGLSFSKERE FATSDAIYTR FEQEFFIKMW
160 170 180 190 200
ERGLIYRKEA YLNWCPKDKT ILANEQVIEG KCWRCDTPVV QKQMFQYYIK
210 220 230 240 250
ITDYADELLE CLNKLEGHWP SQVLSMQRNW IGKSKGLSFT FDFSVDSLQK
260 270 280 290 300
LGNGKVKLEV FTTRPDTIYG VTYCAVAPEH PIVQQLIENK SLDESVIKSI
310 320 330 340 350
EAIKNTTARA RAMSEKVGFD LGVYVIHPLT QEKLPVWVAN FVLMDYGSGA
360 370 380 390 400
VMSVPMHDER DFEFAKTYAL PFKCVLTKEI DGEEPTQEIC AAYEEGFLIN
410 420 430 440 450
SGEFSGMSSS QAKERIIAHF ENASIGKGIT NYRLRDWGVS RQRYWGAPIP
460 470 480 490 500
MVHCQSCGIV PEKIENLPIT LPEDVVIDGE GNPLDKHLVW KDCLCPKCGK
510 520 530 540 550
KAQRESDTMD TFIQSSWYFL RYSTPRKLWE KQAFDKESLT YWLNVDEYIG
560 570 580 590 600
GIEHAILHLL YARFWTKVLR DLGYIEIDEP FANLLTQGMV LKDGAKMSKS
610 620 630 640 650
KGNIVNPNEL IAHYGADTAR LFVLFAAPPT RELEWNDKAV EGAHRFLKRL
660 670 680 690 700
WERAEHIESC TQKPHINHKT LQKNEQYARQ KVYEALQKSN EIFSKKQSGY
710 720 730 740 750
AFNTLIAASM EAFNALNEQE NPLVWTEGYF VLLHILEPIV PHICWELSEQ
760 770 780 790 800
YFRRCNFAPL SVDKDALTKE SVIYAITING KKRAEVEMPL GLSKEEIIIQ
810 820 830
AKESVPKWLE GVEILKEIIV PNKLVNLVVK
Length:830
Mass (Da):95,681
Last modified:October 1, 2003 - v1
Checksum:iCC08CB32DA94E06F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP77062.1.
RefSeqiNP_859996.1. NC_004917.1.
WP_011115307.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77062; AAP77062; HH_0465.
KEGGihhe:HH0465.
PATRICi20588384. VBIHelHep90276_0470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP77062.1.
RefSeqiNP_859996.1. NC_004917.1.
WP_011115307.1. NC_004917.1.

3D structure databases

ProteinModelPortaliQ7VIY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235279.HH0465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP77062; AAP77062; HH_0465.
KEGGihhe:HH0465.
PATRICi20588384. VBIHelHep90276_0470.

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-482-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiSYL_HELHP
AccessioniPrimary (citable) accession number: Q7VIY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.