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Q7VIY7

- SYL_HELHP

UniProt

Q7VIY7 - SYL_HELHP

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Protein
Leucine--tRNA ligase
Gene
leuS, HH_0465
Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei599 – 5991ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:HH_0465
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Leucine--tRNA ligaseUniRule annotation
PRO_0000152025Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH0465.

Structurei

3D structure databases

ProteinModelPortaliQ7VIY7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi596 – 6005"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VIY7-1 [UniParc]FASTAAdd to Basket

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MQERKYNPKD IESKWQQFWT EHKSFEPFDI DIATSDSMKK KYILSMFPYP    50
SGAIHMGHVR NYCIGDALAR NYRQNGYNVL HPMGWDAFGM PAENAAIKHK 100
THPKTWTYSN IDTMRKELAT LGLSFSKERE FATSDAIYTR FEQEFFIKMW 150
ERGLIYRKEA YLNWCPKDKT ILANEQVIEG KCWRCDTPVV QKQMFQYYIK 200
ITDYADELLE CLNKLEGHWP SQVLSMQRNW IGKSKGLSFT FDFSVDSLQK 250
LGNGKVKLEV FTTRPDTIYG VTYCAVAPEH PIVQQLIENK SLDESVIKSI 300
EAIKNTTARA RAMSEKVGFD LGVYVIHPLT QEKLPVWVAN FVLMDYGSGA 350
VMSVPMHDER DFEFAKTYAL PFKCVLTKEI DGEEPTQEIC AAYEEGFLIN 400
SGEFSGMSSS QAKERIIAHF ENASIGKGIT NYRLRDWGVS RQRYWGAPIP 450
MVHCQSCGIV PEKIENLPIT LPEDVVIDGE GNPLDKHLVW KDCLCPKCGK 500
KAQRESDTMD TFIQSSWYFL RYSTPRKLWE KQAFDKESLT YWLNVDEYIG 550
GIEHAILHLL YARFWTKVLR DLGYIEIDEP FANLLTQGMV LKDGAKMSKS 600
KGNIVNPNEL IAHYGADTAR LFVLFAAPPT RELEWNDKAV EGAHRFLKRL 650
WERAEHIESC TQKPHINHKT LQKNEQYARQ KVYEALQKSN EIFSKKQSGY 700
AFNTLIAASM EAFNALNEQE NPLVWTEGYF VLLHILEPIV PHICWELSEQ 750
YFRRCNFAPL SVDKDALTKE SVIYAITING KKRAEVEMPL GLSKEEIIIQ 800
AKESVPKWLE GVEILKEIIV PNKLVNLVVK 830
Length:830
Mass (Da):95,681
Last modified:October 1, 2003 - v1
Checksum:iCC08CB32DA94E06F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77062.1.
RefSeqiNP_859996.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77062; AAP77062; HH_0465.
GeneIDi1493519.
KEGGihhe:HH0465.
PATRICi20588384. VBIHelHep90276_0470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77062.1 .
RefSeqi NP_859996.1. NC_004917.1.

3D structure databases

ProteinModelPortali Q7VIY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235279.HH0465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP77062 ; AAP77062 ; HH_0465 .
GeneIDi 1493519.
KEGGi hhe:HH0465.
PATRICi 20588384. VBIHelHep90276_0470.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HHEP235279:GHUA-482-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiSYL_HELHP
AccessioniPrimary (citable) accession number: Q7VIY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi