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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139L-tryptophanUniRule annotation1
Binding sitei190ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 17ATPUniRule annotation3
Nucleotide bindingi23 – 24ATPUniRule annotation2
Nucleotide bindingi151 – 153ATPUniRule annotation3
Nucleotide bindingi199 – 203ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:HH_0558
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000002495 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366361 – 332Tryptophan--tRNA ligaseAdd BLAST332

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi235279.HH0558

Structurei

3D structure databases

ProteinModelPortaliQ7VIP6
SMRiQ7VIP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi16 – 24"HIGH" regionUniRule annotation9
Motifi199 – 203"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTSSKKRI FSGIQPTGNI HLGNYLGAVR HWVDSQEQYE NIFCVVNSHA
60 70 80 90 100
ITIRQDPQEL QNKTYELAGI LLACGIDTKK SHLFIQSQID EHAALAWILD
110 120 130 140 150
CNIPMGDMSR MTQFKDKSNK NPKNINVGLF NYPALMAADI LLYQADFVPV
160 170 180 190 200
GEDQKQHLEL TRDVAMRFNR DYGECFNIPE PMIPQVGARV MGLDNPQSKM
210 220 230 240 250
SKSAQGENHA IFLLDSPDVI TRKCKKAVTD SQSNIVFDES RAGLYNLLCI
260 270 280 290 300
YEIFTQKSRK SIEAEFEGKG YGHLKMALAE VIIESLRPIQ QSYAKISQDK
310 320 330
TYIQSVLTKS ADSIRPIAKN TYENAKRLVG LV
Length:332
Mass (Da):37,421
Last modified:October 1, 2003 - v1
Checksum:iEEE77222CD3386CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA Translation: AAP77155.1
RefSeqiWP_011115400.1, NC_004917.1

Genome annotation databases

EnsemblBacteriaiAAP77155; AAP77155; HH_0558
KEGGihhe:HH_0558

Similar proteinsi

Entry informationi

Entry nameiSYW_HELHP
AccessioniPrimary (citable) accession number: Q7VIP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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