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Q7VIP6 (SYW_HELHP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase
EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:HH_0558
OrganismHelicobacter hepaticus (strain ATCC 51449 / 3B1) [Complete proteome] [HAMAP]
Taxonomic identifier235279 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136636

Regions

Motif16 – 249"HIGH" region HAMAP-Rule MF_00140
Motif199 – 2035"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2021ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VIP6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EEE77222CD3386CA

FASTA33237,421
        10         20         30         40         50         60 
MSHTSSKKRI FSGIQPTGNI HLGNYLGAVR HWVDSQEQYE NIFCVVNSHA ITIRQDPQEL 

        70         80         90        100        110        120 
QNKTYELAGI LLACGIDTKK SHLFIQSQID EHAALAWILD CNIPMGDMSR MTQFKDKSNK 

       130        140        150        160        170        180 
NPKNINVGLF NYPALMAADI LLYQADFVPV GEDQKQHLEL TRDVAMRFNR DYGECFNIPE 

       190        200        210        220        230        240 
PMIPQVGARV MGLDNPQSKM SKSAQGENHA IFLLDSPDVI TRKCKKAVTD SQSNIVFDES 

       250        260        270        280        290        300 
RAGLYNLLCI YEIFTQKSRK SIEAEFEGKG YGHLKMALAE VIIESLRPIQ QSYAKISQDK 

       310        320        330 
TYIQSVLTKS ADSIRPIAKN TYENAKRLVG LV

« Hide

References

[1]"The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus."
Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M., Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R., Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B. expand/collapse author list , Shen Z., Weber J., Frosch M., Fox J.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51449 / 3B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017125 Genomic DNA. Translation: AAP77155.1.
RefSeqNP_860089.1. NC_004917.1.

3D structure databases

ProteinModelPortalQ7VIP6.
ModBaseSearch...

Protein-protein interaction databases

STRING235279.HH0558.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP77155; AAP77155; HH_0558.
GeneID1493612.
KEGGhhe:HH0558.
PATRIC20588572. VBIHelHep90276_0563.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMAHDCLYCV.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycHHEP235279:GHUA-559-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_HELHP
AccessionPrimary (citable) accession number: Q7VIP6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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