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Q7VIL0

- PNP_HELHP

UniProt

Q7VIL0 - PNP_HELHP

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi491 – 4911MagnesiumUniRule annotation
Metal bindingi497 – 4971MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-614-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:HH_0594
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709Polyribonucleotide nucleotidyltransferasePRO_0000329677Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH0594.

Structurei

3D structure databases

ProteinModelPortaliQ7VIL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 61761KHUniRule annotationAdd
BLAST
Domaini641 – 70969S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VIL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQHIKLEFEN LSEQYSFNYV AQAANGGILY QNGGSVLLAS VCTQENEKYD
60 70 80 90 100
DEFLPLSVQY IEKTYANNKF PSGFIKREGK PSEFEILTSR LIDRTLRPLF
110 120 130 140 150
PKGYTYITSI VVMVLSYDGK SDLQLNALNA AACALYVSDL PLESLQDKAV
160 170 180 190 200
SGVRIGRKDG HFIINPTMEQ LSESELNLFV SGRDDELLMI EMKSIRTAQG
210 220 230 240 250
ANELSEENFL EALECAKNYI KNATQTYHQQ FAPYKKSPFA FESANDELDE
260 270 280 290 300
QLLNIIQTHY HTPITEAIKH MAKSERHTQL KALIKQVVRE CEIEDEKKVQ
310 320 330 340 350
EHIMAYKRKL VREMILQSHI RADGRGLKDV RPISIQTNIL PFAHGSVLFT
360 370 380 390 400
RGQTQALVSA TIGGDNDAQN YEMLGSKNAL KKRFLFHYNF PSFSVGEASM
410 420 430 440 450
IGSVGRRELG HGNLAKRALH SSVQEQDKTI RLVSEILESN GSSSMASVCG
460 470 480 490 500
GSLALCACGI KVESLIAGVA MGLVTQDEQC AILTDISGLE DHDGDMDFKV
510 520 530 540 550
AGGYKGISAM QMDIKLGGIT QEILCQALFQ AKEAREQILA IMEEARAKIV
560 570 580 590 600
LNDVILPKSE SFMIPPHKIV EVIGAGGRVI KDIIERFEVS IDLARESGMV
610 620 630 640 650
SVSASNVENL QKAKTFILQL VSSAGTKKEY EKVDWESYAV GERFVGKIKK
660 670 680 690 700
IVDFGIFVEL PRGGDGLIHI SKITKDKTQQ LSEIFHNVSE LECEILSQNK

NKVELGLVE
Length:709
Mass (Da):78,828
Last modified:October 1, 2003 - v1
Checksum:iCD2873594EAE8023
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77191.1.
RefSeqiNP_860125.1. NC_004917.1.
WP_011115436.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77191; AAP77191; HH_0594.
GeneIDi1493648.
KEGGihhe:HH0594.
PATRICi20588646. VBIHelHep90276_0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77191.1 .
RefSeqi NP_860125.1. NC_004917.1.
WP_011115436.1. NC_004917.1.

3D structure databases

ProteinModelPortali Q7VIL0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235279.HH0594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP77191 ; AAP77191 ; HH_0594 .
GeneIDi 1493648.
KEGGi hhe:HH0594.
PATRICi 20588646. VBIHelHep90276_0598.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci HHEP235279:GHUA-614-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiPNP_HELHP
AccessioniPrimary (citable) accession number: Q7VIL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3