Q7VIJ7 (DXS_HELHP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	HH_0608

Organism

Helicobacter hepaticus (strain ATCC 51449 / 3B1) [Complete proteome] [HAMAP]

Taxonomic identifier

235279 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189118

Sequences

	Sequence		Length	Mass (Da)
	Q7VIJ7 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 82C368468D5ED10C	FASTA	629	69,412
	10 20 30 40 50 60 MEVKTLDVAN FLARIQKQES TFESLSKFSP TQLKELATCI RHRILEVVSS NGGHLSSTLG 70 80 90 100 110 120 AVDLIIGMHL VFDANTNPFI FDVSHQAYAH KLLTGRWNDF SSLRQFGGLS GFCNPKESPS 130 140 150 160 170 180 DYFIAGHSST SISLAVGAAK ALALKGSASM PVVMIGDGSM SAGLVYEALN ELGDKKYPMV 190 200 210 220 230 240 IILNDNKMSI SKPIGAISNY LSQILTTSIY QKIRDTIKKV LTKMPDSATY LAKRFEESLK 250 260 270 280 290 300 LITPGILFEE LGLDYVGPID GHNIELIIAT LQRAKEMRKP VIIHAQTLKG KGYEIAEGRF 310 320 330 340 350 360 EHWHGVGPFD VSTGSSLKSS APQSPTAVFS ESLESYLTDE KVVGVTAAMP SGTGLDKLIE 370 380 390 400 410 420 KYPQRFWDVA ICEAHAVTSM AAIAKEGFKP FVAIYSTFLQ RAYDQIIHDV GILGLPVRFC 430 440 450 460 470 480 IDRAGIVGED GETHQGLFDI AYLRSIPHMV LFAPRDNASL QQAVAFAYRY NDSPCAFRYP 490 500 510 520 530 540 RGSFTLEEGV FVSNEFVLGQ AEMLKRGKKI LLVGYGNGVG RAYKVYQALI TEGYEPSLLD 550 560 570 580 590 600 LRFVKPLDKH MLNEVFKTHT HICVFSDSYY MGGVASALLE FMAEENIKDV QLKSFEIKDR 610 620 FVPHGNTALI EQSLGLDTPH LVSKIKEWI

References

[1]

"The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus." Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M., Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R., Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B. , Shen Z., Weber J., Frosch M., Fox J.G. Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003) [PubMed: 12810954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51449 / 3B1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017125 Genomic DNA. Translation: AAP77205.1.
RefSeq	NP_860139.1. NC_004917.1.
3D structure databases
ProteinModelPortal	Q7VIJ7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1493662.
GenomeReviews	Gene locus HH_0608 in contig AE017125_GR.
KEGG	hhe:HH0608.
NMPDR	fig|235279.1.peg.608.
PATRIC	20588672. VBIHelHep90276_0610.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	RFANEHD.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	HHEP235279:HH_0608-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_HELHP

Accession

Primary (citable) accession number: Q7VIJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program