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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251S-adenosyl-L-methionineUniRule annotation
Binding sitei150 – 1501S-adenosyl-L-methionineUniRule annotation
Binding sitei177 – 1771S-adenosyl-L-methionineUniRule annotation
Binding sitei203 – 2031SubstrateUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-808-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:HH_0785
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396tRNA (guanine-N(7)-)-methyltransferasePRO_0000171334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH0785.

Structurei

3D structure databases

ProteinModelPortaliQ7VI24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VI24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHFLASHIT LPPMPFTQEG YTFVYEAKQC NDSSQSLILV RYEDNEFFLR
60 70 80 90 100
KAWRGNKNNA ILKCEKSTKT QPTGIIKNAL KILCAYQKNV ISHNLNKNTP
110 120 130 140 150
RQNLQSPYFQ SMDFFLDFAK PCLIEIGFGS GRHLLHLAQS NPHFMCIGIE
160 170 180 190 200
IHTPSIEQIL RQVQLLGLEN LYIINGDARI LLEILSSHIA QGIYVHFPVP
210 220 230 240 250
WNKKHHRRIF SPKFFQESLR VLDNNGVLHL RSDDEIYFQD ALSLALQQES
260 270 280 290 300
ISLEIHKNQQ EVITSKYEAR WKKQQKNIYD LKIFHTYKNT NNEKNVKNTQ
310 320 330 340 350
KNFYFDKILR KNLDNYKNFP HKKIANDWFL HIDNLYCAGD IYVLALCFGD
360 370 380 390
FNQPQSKFLQ IEFCNNVSAR YIGSNPIPTQ AAIKAHKYLI QILTQE
Length:396
Mass (Da):46,253
Last modified:October 1, 2003 - v1
Checksum:i76C6FB9B861941EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP77382.1.
RefSeqiNP_860316.1. NC_004917.1.
WP_011115627.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77382; AAP77382; HH_0785.
KEGGihhe:HH0785.
PATRICi20589022. VBIHelHep90276_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP77382.1.
RefSeqiNP_860316.1. NC_004917.1.
WP_011115627.1. NC_004917.1.

3D structure databases

ProteinModelPortaliQ7VI24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235279.HH0785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP77382; AAP77382; HH_0785.
KEGGihhe:HH0785.
PATRICi20589022. VBIHelHep90276_0784.

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Enzyme and pathway databases

UniPathwayiUPA00989.
BioCyciHHEP235279:GHUA-808-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiTRMB_HELHP
AccessioniPrimary (citable) accession number: Q7VI24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: April 1, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.