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Q7VI24

- TRMB_HELHP

UniProt

Q7VI24 - TRMB_HELHP

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, HH_0785
Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251S-adenosyl-L-methionine By similarity
Binding sitei150 – 1501S-adenosyl-L-methionine By similarity
Binding sitei177 – 1771S-adenosyl-L-methionine By similarity
Binding sitei203 – 2031Substrate By similarity
Binding sitei233 – 2331Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-808-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:HH_0785
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH0785.

Structurei

3D structure databases

ProteinModelPortaliQ7VI24.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VI24-1 [UniParc]FASTAAdd to Basket

« Hide

MPHFLASHIT LPPMPFTQEG YTFVYEAKQC NDSSQSLILV RYEDNEFFLR    50
KAWRGNKNNA ILKCEKSTKT QPTGIIKNAL KILCAYQKNV ISHNLNKNTP 100
RQNLQSPYFQ SMDFFLDFAK PCLIEIGFGS GRHLLHLAQS NPHFMCIGIE 150
IHTPSIEQIL RQVQLLGLEN LYIINGDARI LLEILSSHIA QGIYVHFPVP 200
WNKKHHRRIF SPKFFQESLR VLDNNGVLHL RSDDEIYFQD ALSLALQQES 250
ISLEIHKNQQ EVITSKYEAR WKKQQKNIYD LKIFHTYKNT NNEKNVKNTQ 300
KNFYFDKILR KNLDNYKNFP HKKIANDWFL HIDNLYCAGD IYVLALCFGD 350
FNQPQSKFLQ IEFCNNVSAR YIGSNPIPTQ AAIKAHKYLI QILTQE 396
Length:396
Mass (Da):46,253
Last modified:October 1, 2003 - v1
Checksum:i76C6FB9B861941EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77382.1.
RefSeqiNP_860316.1. NC_004917.1.
WP_011115627.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77382; AAP77382; HH_0785.
GeneIDi1492474.
KEGGihhe:HH0785.
PATRICi20589022. VBIHelHep90276_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77382.1 .
RefSeqi NP_860316.1. NC_004917.1.
WP_011115627.1. NC_004917.1.

3D structure databases

ProteinModelPortali Q7VI24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235279.HH0785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP77382 ; AAP77382 ; HH_0785 .
GeneIDi 1492474.
KEGGi hhe:HH0785.
PATRICi 20589022. VBIHelHep90276_0784.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi SKYEARW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HHEP235279:GHUA-808-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiTRMB_HELHP
AccessioniPrimary (citable) accession number: Q7VI24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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