Q7VI01 (Q7VI01_HELHP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid A disaccharide synthetase EMBL AAP77407.1
EC=2.4.1.182 EMBL AAP77407.1

Gene names

Name:	lpxB EMBL AAP77407.1
Ordered Locus Names:	HH_0810

Organism

Helicobacter hepaticus (strain ATCC 51449 / 3B1) [Complete proteome] [HAMAP]

Taxonomic identifier

235279 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL AAP77407.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7VI01 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: EFF74A9B22A56508	FASTA	388	43,873
	10 20 30 40 50 60 MQYQSAYTTP KRLFVSACEP SANLHLKFLA QNLDKSTHIC GVFEPETFTN FPYASPSYTL 70 80 90 100 110 120 KDFAIMGFFD VIKKLAFFKR AIKEMSELAA QCDVVLLMDS SSFNLPIAKT LKKNTTKVPV 130 140 150 160 170 180 IYYILPQVWA WKPWRAKEIE SVCDYLCAIL PFELQMYPNA VAENRAFYVG HPLLDEIPTL 190 200 210 220 230 240 KEQPLPLENG KIAFMPGSRK GEIKRIFPIF AAVAKEIANP KILVLPEHFK NLDKEAMHNI 250 260 270 280 290 300 YGEDIHYFEL SFDANSALLE SSFAFVCSGT ATLQATLIGT PLVLGYKTRT IDVMIARAFV 310 320 330 340 350 360 KLKHIGLANI LYNALHCGNP RTGEKEIHTE LIQSSLTKEN LLNIYHATNA HEFFAKAKEI 370 380 RSYLACGSAE RVIKLLDKLL KERGIYDL

References

[1]

"The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus." Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M., Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R., Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B. , Shen Z., Weber J., Frosch M., Fox J.G. Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003) [PubMed: 12810954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51449 / 3B1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017125 Genomic DNA. Translation: AAP77407.1.
RefSeq	NP_860341.1. NC_004917.1.
3D structure databases
ProteinModelPortal	Q7VI01.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1492499.
GenomeReviews	Gene locus HH_0810 in contig AE017125_GR.
KEGG	hhe:HH0810.
NMPDR	fig|235279.1.peg.810.
PATRIC	20589072. VBIHelHep90276_0809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	PRK14089.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q7VI01_HELHP

Accession

Primary (citable) accession number: Q7VI01

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)