Q7VH57 (DNAA_HELHP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	HH_1110

Organism

Helicobacter hepaticus (strain ATCC 51449 / 3B1) [Complete proteome] [HAMAP]

Taxonomic identifier

235279 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114187
Regions
	Nucleotide binding	158 – 165	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VH57 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 598536C4C461D4A7	FASTA	456	52,457
	10 20 30 40 50 60 MKLKILHFTS GNKLHIDNIL KKLKSKLSEF EYQFYISLME YDENASRTDM KVFYVPNIFV 70 80 90 100 110 120 ANWIKSNHLE SIIDAFEEES NNGVRPEIHI KVKEKKENVK SLKNNKSMLY FNTNGLSLNP 130 140 150 160 170 180 FYTFENFVVG KSNEYAYTIA KLVLQQQASA YNPVLLYGKS GLGKTHLLNA IGNDVKEKNK 190 200 210 220 230 240 NVLYVTSEDF LNDYMDKIKR KTMDSFRDKY RKCDYLLIDD VQFFGGKEGI QEELLHTFNT 250 260 270 280 290 300 LHNSQKQIVM TSDKPPKEIK GLEERLRTRF EWGAMAEITN PELETKIAII KSKCEVNRIV 310 320 330 340 350 360 LENEVIDYIA SNIYGNIRQI EGILSTINAH INLSPESSSL KIAKNVLKNY QIEKLEGITL 370 380 390 400 410 420 DNIIKVVSKE LNIKPSEIVS KERNRKVTFA RRAVIYLAHS LMINSMNIIA KELGMKDHSS 430 440 450 VSKALKAIKK EIAENSTTRN IIEDMKSKIQ QSLDSV

References

[1]

"The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus." Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M., Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R., Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B. , Shen Z., Weber J., Frosch M., Fox J.G. Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003) [PubMed: 12810954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51449 / 3B1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017125 Genomic DNA. Translation: AAP77707.1.
RefSeq	NP_860641.1. NC_004917.1.
3D structure databases
ProteinModelPortal	Q7VH57.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1492798.
GenomeReviews	Gene locus HH_1110 in contig AE017125_GR.
KEGG	hhe:HH1110.
NMPDR	fig|235279.1.peg.1110.
PATRIC	20589684. VBIHelHep90276_1104.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	HHEP235279:HH_1110-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_HELHP

Accession

Primary (citable) accession number: Q7VH57

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program