Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7VGM5

- NADK_HELHP

UniProt

Q7VGM5 - NADK_HELHP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene

nadK

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptorUniRule annotation
Binding sitei188 – 1881NADUniRule annotation
Binding sitei190 – 1901NADUniRule annotation
Binding sitei198 – 1981NAD; via carbonyl oxygenUniRule annotation
Binding sitei225 – 2251NAD; via carbonyl oxygenUniRule annotation
Binding sitei257 – 2571NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 742NADUniRule annotation
Nucleotide bindingi160 – 1612NADUniRule annotation
Nucleotide bindingi201 – 2066NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-1333-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:HH_1296
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301NAD kinasePRO_0000229644Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH1296.

Structurei

3D structure databases

ProteinModelPortaliQ7VGM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VGM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSHNAPITK VGVILRPSSP ELKTTFLQIK EELNNAGIEV ILESISGGMI
60 70 80 90 100
ELLGRDFHQL ATQCDALFSL GGDGTLISML RRAFEYELPC MGINTGRLGF
110 120 130 140 150
LTALMPQNLH TFTSHLKSGD YTLQKHLVLQ ARIYSTLNTA YENNLDNKNQ
160 170 180 190 200
TPTQTLIAIN EFLISKHELS GMVHIDASID RKYFNTYRCD GLIIGTPAGS
210 220 230 240 250
TAYNISAGGS VIYPYCRNIL LTPIAPHSLT QRPLVLSDEF MLEFYAKERA
260 270 280 290 300
KLIIDGQEMI DIMPSDRVQI QALPQSAMLM YPPTRDYFSV LKEKFKWGEE

H
Length:301
Mass (Da):33,777
Last modified:October 1, 2003 - v1
Checksum:iA52412F0CD5A6A31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP77893.1.
RefSeqiNP_860827.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77893; AAP77893; HH_1296.
GeneIDi1492984.
KEGGihhe:HH1296.
PATRICi20590044. VBIHelHep90276_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP77893.1 .
RefSeqi NP_860827.1. NC_004917.1.

3D structure databases

ProteinModelPortali Q7VGM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235279.HH1296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP77893 ; AAP77893 ; HH_1296 .
GeneIDi 1492984.
KEGGi hhe:HH1296.
PATRICi 20590044. VBIHelHep90276_1282.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci HHEP235279:GHUA-1333-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiNADK_HELHP
AccessioniPrimary (citable) accession number: Q7VGM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3