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Q7VGM5

- NADK_HELHP

UniProt

Q7VGM5 - NADK_HELHP

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Protein
NAD kinase
Gene
nadK, HH_1296
Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptor By similarity
Binding sitei188 – 1881NAD By similarity
Binding sitei190 – 1901NAD By similarity
Binding sitei198 – 1981NAD; via carbonyl oxygen By similarity
Binding sitei225 – 2251NAD; via carbonyl oxygen By similarity
Binding sitei257 – 2571NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 742NAD By similarity
Nucleotide bindingi160 – 1612NAD By similarity
Nucleotide bindingi201 – 2066NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-1333-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:HH_1296
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301NAD kinaseUniRule annotation
PRO_0000229644Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235279.HH1296.

Structurei

3D structure databases

ProteinModelPortaliQ7VGM5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VGM5-1 [UniParc]FASTAAdd to Basket

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MKSHNAPITK VGVILRPSSP ELKTTFLQIK EELNNAGIEV ILESISGGMI    50
ELLGRDFHQL ATQCDALFSL GGDGTLISML RRAFEYELPC MGINTGRLGF 100
LTALMPQNLH TFTSHLKSGD YTLQKHLVLQ ARIYSTLNTA YENNLDNKNQ 150
TPTQTLIAIN EFLISKHELS GMVHIDASID RKYFNTYRCD GLIIGTPAGS 200
TAYNISAGGS VIYPYCRNIL LTPIAPHSLT QRPLVLSDEF MLEFYAKERA 250
KLIIDGQEMI DIMPSDRVQI QALPQSAMLM YPPTRDYFSV LKEKFKWGEE 300
H 301
Length:301
Mass (Da):33,777
Last modified:October 1, 2003 - v1
Checksum:iA52412F0CD5A6A31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77893.1.
RefSeqiNP_860827.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP77893; AAP77893; HH_1296.
GeneIDi1492984.
KEGGihhe:HH1296.
PATRICi20590044. VBIHelHep90276_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP77893.1 .
RefSeqi NP_860827.1. NC_004917.1.

3D structure databases

ProteinModelPortali Q7VGM5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 235279.HH1296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP77893 ; AAP77893 ; HH_1296 .
GeneIDi 1492984.
KEGGi hhe:HH1296.
PATRICi 20590044. VBIHelHep90276_1282.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci HHEP235279:GHUA-1333-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiNADK_HELHP
AccessioniPrimary (citable) accession number: Q7VGM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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