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Protein

Malate dehydrogenase

Gene

mdh

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84SubstrateBy similarity1
Binding sitei90SubstrateBy similarity1
Binding sitei97NADBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei153SubstrateBy similarity1
Active sitei177Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 15NADBy similarity7
Nucleotide bindingi120 – 122NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdhBy similarity
Ordered Locus Names:HH_1571
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000002495 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134561 – 315Malate dehydrogenaseAdd BLAST315

Proteomic databases

PRIDEiQ7VFV4

Interactioni

Protein-protein interaction databases

STRINGi235279.HH1571

Structurei

3D structure databases

ProteinModelPortaliQ7VFV4
SMRiQ7VFV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VFV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKIAIIGG SGNVGSHIAF LGAMRHIAKE ILLFSNDIPR CKGVGLDISQ
60 70 80 90 100
AAAIFDIPIL IKGCNSYEEI AESEVVIITA GFPRTPNMTR NDLLLKNASI
110 120 130 140 150
IQEISSNVAR IAPQSLLIVV SNPLDAMCLV AKQWSKFEKE RVIGMAGILD
160 170 180 190 200
SARLTYESKV MLGDFNKHIQ SYVIGSHSDD MLPLLRHCLC EGKVFTDIFT
210 220 230 240 250
PKMQEELIKE TKGGGAKIVN YYQKGSAYFA PASGVIKILE AISTLNEEIL
260 270 280 290 300
VCSVFTEGEY GIKDIYLGLP IKLGKKGVEH IVELPLNQQE QEMLNISTQG
310
IKEQVEILKD NKLLY
Length:315
Mass (Da):34,703
Last modified:October 1, 2003 - v1
Checksum:iF652AE4ECD1D80BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA Translation: AAP78168.1
RefSeqiWP_011116411.1, NC_004917.1

Genome annotation databases

EnsemblBacteriaiAAP78168; AAP78168; HH_1571
KEGGihhe:HH_1571

Similar proteinsi

Entry informationi

Entry nameiMDH_HELHP
AccessioniPrimary (citable) accession number: Q7VFV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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