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Q7VET8

- GCSP_MYCBO

UniProt

Q7VET8 - GCSP_MYCBO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Synonyms:gcvB
    Ordered Locus Names:Mb1863
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 941941Glycine dehydrogenase (decarboxylating)PRO_0000166918Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei692 – 6921N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi233413.Mb1863.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VET8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFHQYRSE.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VET8-1 [UniParc]FASTAAdd to Basket

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    MSDHSTFADR HIGLDSQAVA TMLAVIGVDS LDDLAVKAVP AGILDTLTDT    50
    GAAPGLDSLP PAASEAEALA ELRALADANT VAVSMIGQGY YDTHTPPVLL 100
    RNIIENPAWY TAYTPYQPEI SQGRLEALLN FQTLVTDLTG LEIANASMLD 150
    EGTAAAEAMT LMHRAARGPV KRVVVDADVF TQTAAVLATR AKPLGIEIVT 200
    ADLRAGLPDG EFFGAIAQLP GASGRITDWS ALVQQAHDRG ALVAVGADLL 250
    ALTLIAPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH AKHARQLPGR 300
    LVGVSVDSDG TPAYRLALQT REQHIRRDKA TSNICTAQVL LAVLAAMYAS 350
    YHGAGGLTAI ARRVHAHAEA IAGALGDALV HDKYFDTVLA RVPGRADEVL 400
    ARAKANGINL WRVDADHVSV ACDEATTDTH VAVVLDAFGV AAAAPAHADI 450
    ATRTSEFLTH PAFTQYRTET SMMRYLRALA DKDIALDRSM IPLGSCTMKL 500
    NAAAEMESIT WPEFGRQHPF APASDTAGLR QLVADLQSWL VLITGYDAVS 550
    LQPNAGSQGE YAGLLAIHEY HASRGEPHRD ICLIPSSAHG TNAASAALAG 600
    MRVVVVDCHD NGDVDLDDLR AKVGEHAERL SALMITYPST HGVYEHDIAE 650
    ICAAVHDAGG QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG 700
    GGPGVGPVAV RAHLAPFLPG HPFAPELPKG YPVSSAPYGS ASILPITWAY 750
    IRMMGAEGLR AASLTAITSA NYIARRLDEY YPVLYTGENG MVAHECILDL 800
    RGITKLTGIT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP TESESLAEVD 850
    AFCEAMIGIR AEIDKVGAGE WPVDDNPLRG APHTAQCLLA SDWDHPYTRE 900
    QAAYPLGTAF RPKVWPAVRR IDGAYGDRNL VCSCPPVEAF A 941
    Length:941
    Mass (Da):99,453
    Last modified:October 1, 2003 - v1
    Checksum:i4572D7C6FC2CEA8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43112.1.
    RefSeqiNP_855515.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD94566; CAD94566; Mb1863.
    GeneIDi1092983.
    KEGGimbo:Mb1863.
    PATRICi18005795. VBIMycBov88188_2042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43112.1 .
    RefSeqi NP_855515.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali Q7VET8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb1863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD94566 ; CAD94566 ; Mb1863 .
    GeneIDi 1092983.
    KEGGi mbo:Mb1863.
    PATRICi 18005795. VBIMycBov88188_2042.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FHQYRSE.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiGCSP_MYCBO
    AccessioniPrimary (citable) accession number: Q7VET8
    Secondary accession number(s): X2BIL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3