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Q7VET8

- GCSP_MYCBO

UniProt

Q7VET8 - GCSP_MYCBO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, gcvB, Mb1863
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Synonyms:gcvB
Ordered Locus Names:Mb1863
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei692 – 6921N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi233413.Mb1863.

Structurei

3D structure databases

ProteinModelPortaliQ7VET8.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFHQYRSE.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VET8-1 [UniParc]FASTAAdd to Basket

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MSDHSTFADR HIGLDSQAVA TMLAVIGVDS LDDLAVKAVP AGILDTLTDT    50
GAAPGLDSLP PAASEAEALA ELRALADANT VAVSMIGQGY YDTHTPPVLL 100
RNIIENPAWY TAYTPYQPEI SQGRLEALLN FQTLVTDLTG LEIANASMLD 150
EGTAAAEAMT LMHRAARGPV KRVVVDADVF TQTAAVLATR AKPLGIEIVT 200
ADLRAGLPDG EFFGAIAQLP GASGRITDWS ALVQQAHDRG ALVAVGADLL 250
ALTLIAPPGE IGADVAFGTT QRFGVPMGFG GPHAGYLAVH AKHARQLPGR 300
LVGVSVDSDG TPAYRLALQT REQHIRRDKA TSNICTAQVL LAVLAAMYAS 350
YHGAGGLTAI ARRVHAHAEA IAGALGDALV HDKYFDTVLA RVPGRADEVL 400
ARAKANGINL WRVDADHVSV ACDEATTDTH VAVVLDAFGV AAAAPAHADI 450
ATRTSEFLTH PAFTQYRTET SMMRYLRALA DKDIALDRSM IPLGSCTMKL 500
NAAAEMESIT WPEFGRQHPF APASDTAGLR QLVADLQSWL VLITGYDAVS 550
LQPNAGSQGE YAGLLAIHEY HASRGEPHRD ICLIPSSAHG TNAASAALAG 600
MRVVVVDCHD NGDVDLDDLR AKVGEHAERL SALMITYPST HGVYEHDIAE 650
ICAAVHDAGG QVYVDGANLN ALVGLARPGK FGGDVSHLNL HKTFCIPHGG 700
GGPGVGPVAV RAHLAPFLPG HPFAPELPKG YPVSSAPYGS ASILPITWAY 750
IRMMGAEGLR AASLTAITSA NYIARRLDEY YPVLYTGENG MVAHECILDL 800
RGITKLTGIT VDDVAKRLAD YGFHAPTMSF PVAGTLMVEP TESESLAEVD 850
AFCEAMIGIR AEIDKVGAGE WPVDDNPLRG APHTAQCLLA SDWDHPYTRE 900
QAAYPLGTAF RPKVWPAVRR IDGAYGDRNL VCSCPPVEAF A 941
Length:941
Mass (Da):99,453
Last modified:October 1, 2003 - v1
Checksum:i4572D7C6FC2CEA8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43112.1.
RefSeqiNP_855515.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94566; CAD94566; Mb1863.
GeneIDi1092983.
KEGGimbo:Mb1863.
PATRICi18005795. VBIMycBov88188_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43112.1 .
RefSeqi NP_855515.1. NC_002945.3.

3D structure databases

ProteinModelPortali Q7VET8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94566 ; CAD94566 ; Mb1863 .
GeneIDi 1092983.
KEGGi mbo:Mb1863.
PATRICi 18005795. VBIMycBov88188_2042.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FHQYRSE.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiGCSP_MYCBO
AccessioniPrimary (citable) accession number: Q7VET8
Secondary accession number(s): X2BIL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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