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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-2244-MONOMER
UniPathwayiUPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:BQ2027_MB2177C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091871 – 410UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST410

Proteomic databases

PRIDEiQ7VEP8

Structurei

3D structure databases

ProteinModelPortaliQ7VEP8
SMRiQ7VEP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218323
OMAiHQTKNAM

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VEP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDTVSQPAG GRGATAPRPA DAASPSCGSS PSADSLSVVL AGGGTAGHVE
60 70 80 90 100
PAMAVADALV ALDPRVRITA LGTPRGLETR LVPQRGYHLE LITAVPMPRK
110 120 130 140 150
PGGDLARLPS RVWRAVREAR DVLDDVDADV VVGFGGYVAL PAYLAARGLP
160 170 180 190 200
LPPRRRRRIP VVIHEANARA GLANRVGAHT ADRVLSAVPD SGLRRAEVVG
210 220 230 240 250
VPVRASIAAL DRAVLRAEAR AHFGFPDDAR VLLVFGGSQG AVSLNRAVSG
260 270 280 290 300
AAADLAAAGV CVLHAHGPQN VLELRRRAQG DPPYVAVPYL DRMELAYAAA
310 320 330 340 350
DLVICRAGAM TVAEVSAVGL PAIYVPLPIG NGEQRLNALP VVNAGGGMVV
360 370 380 390 400
ADAALTPELV ARQVAGLLTD PARLAAMTAA AARVGHRDAA GQVARAALAV
410
ATGAGARTTT
Length:410
Mass (Da):41,858
Last modified:October 1, 2003 - v1
Checksum:i347DB45D34A4890B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00785.1
RefSeqiNP_855826.1, NC_002945.3
WP_010950665.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO43431; CDO43431; Mb2177c
PATRICifig|233413.5.peg.2393

Similar proteinsi

Entry informationi

Entry nameiMURG_MYCBO
AccessioniPrimary (citable) accession number: Q7VEP8
Secondary accession number(s): A0A1R3Y146, X2BK91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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