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Q7VEK9 (PURL_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2

EC=6.3.5.3
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II
Short name=FGAM synthase II
Gene names
Name:purL
Ordered Locus Names:Pro_0003
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00420.

Sequence similarities

Belongs to the FGAMS family.

Sequence caution

The sequence AAP99049.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 793793Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420
PRO_0000100477

Regions

Nucleotide binding110 – 12112ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q7VEK9 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: DA470F1FED396B31

FASTA79386,331
        10         20         30         40         50         60 
MIKSKDYLVD YNVELALKKE GLTKADYIEI CNRLKRSPNR TELGMFGVMW SEHCCYRNSR 

        70         80         90        100        110        120 
SLLSNFPTTG KNILVGPGEN AGVVDLGEGQ RLAFKIESHN HPSAIEPFQG AATGVGGILR 

       130        140        150        160        170        180 
DIFTMGARPI ALLNSLRFGP LDTPINVGLL EGVVSGIAHY GNCVGVPTVG GEVAFDKSYS 

       190        200        210        220        230        240 
GNPLVNAMAL GIMETKEIVC SGAKGIDFPV IYVGSTTGRD GMGGASFASS ELTQASIDDR 

       250        260        270        280        290        300 
PAVQVGDPFL EKGLIEGCLE AFKTGYVVAA QDMGAAGLTC SCSEMAAKGG VGIELDLDLV 

       310        320        330        340        350        360 
PAREKNMTAY EFLLSESQER MLFVVEPGKE ELIMNKFRKW GLQAKVVGKV LEENIVRVIH 

       370        380        390        400        410        420 
EKQIVVNLPA DSLAEDTPVN KHELLEEPPG FIKDHWKWDE TSLPKVSIKG VHFKENNTIL 

       430        440        450        460        470        480 
DWNQIILRLL DDPTIASKRW IYNQYDYQVQ NNTIIAPGIG DAALIRLREI ENQNQNSNRG 

       490        500        510        520        530        540 
IAAVVDCPNR WVALDPERGA IAAVAEASRN ISCVGAKPLA VTDNLNFSSP EDPIGYWQLA 

       550        560        570        580        590        600 
KACKGLSKAC VVLETPVTGG NVSLYNETAL PNGLKQPIQP TPVVGMIGLI QDINSATRQG 

       610        620        630        640        650        660 
WKDQGDQIYL LGTSIDPSIL NNQNISLAAT SYLENIYGLK TGRPPLIDLE FEKLVQLFLR 

       670        680        690        700        710        720 
ESIANNLIKS AHDISDGGLV IGLAESCISS GLGIECNLPE IDNRLDKLLF AEGGSRVLVS 

       730        740        750        760        770        780 
VSPNNIHNIK NSLNNFNIAN SEQISFNYLG TVTDNKYFQI NINQTKIIDL SVNEITNKFE 

       790 
RSIPRRINST IVS 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAP99049.1. Different initiation.
RefSeqNP_874397.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7VEK9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro0003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP99049; AAP99049; Pro_0003.
GeneID1461381.
KEGGpma:Pro_0003.
PATRIC23026575. VBIProMar8617_0003.

Phylogenomic databases

eggNOGCOG0046.
KOK01952.
OMASQERMLF.
OrthoDBEOG6FNHHR.
ProtClustDBPRK01213.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-3-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
3.90.650.10. 1 hit.
HAMAPMF_00420. PurL_2.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry namePURL_PROMA
AccessionPrimary (citable) accession number: Q7VEK9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways