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Q7VEG4 (SPEA_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Pro_0049
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_0000149968

Regions

Region291 – 30111Substrate-binding Potential

Amino acid modifications

Modified residue1091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VEG4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 142E509509DFE40A

FASTA64872,378
        10         20         30         40         50         60 
MTKSKPATKK NEWTVKDSCS LYGLDLWGEE YFSINDSGNV TVSPQGKEGN SLELTHLLEE 

        70         80         90        100        110        120 
LKGRNLNTPL LLRFDDILED RLKKLHQAFE NAINQYGYNN DYQGVFPIKC NQQRHVVEEI 

       130        140        150        160        170        180 
VTIGRKWHFG LEAGSKAELL IALALVNDPK AFLICNGYKD NRYIETTILA RQLGRQPIVV 

       190        200        210        220        230        240 
IEQSDEVGRI IKASQKLGAA PLIGIRAKLS NQSSGRWGNS VGEKSKFGLS IPEILKAVQE 

       250        260        270        280        290        300 
LTAAGLLNEL ILLHFHVGSQ INDIAILKNA LQEASQIYVE LNRLGAPMGH LDVGGGLGVD 

       310        320        330        340        350        360 
YDGSRTATSA STNYSLQNYA NDVVATIQEC CKAKKVKVPK LISESGRFLS SHFSILIFNV 

       370        380        390        400        410        420 
LGTSSVPTQI AIETSNECLS VKNLRETLMI LHQICEEKKI DVSKLQEAWN DALKFKEDAL 

       430        440        450        460        470        480 
NAFRLGFIDL TERATAEQLT WACAKQIAAH LPNDLKIPKE LLAINKGLTE TYYANISIFR 

       490        500        510        520        530        540 
SAPDTWAIQQ LFPLLPIHRL QEKPDQLGHF ADLTCDSDGK LARFINNGQE KFLLELHTVK 

       550        560        570        580        590        600 
ANENYWIGMF LGGAYQEVMG NLHNLFGSTN AIHIRLTKNG KYKLDHVVRG NSKSDVLQAM 

       610        620        630        640 
EHDSEQLLER IRMASESAIQ QGSLKINDAQ RLIEHVETSL RQSTYLQE 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAP99095.1.
RefSeqNP_874443.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7VEG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro0049.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP99095; AAP99095; Pro_0049.
GeneID1461427.
KEGGpma:Pro_0049.
PATRIC23026671. VBIProMar8617_0051.

Phylogenomic databases

eggNOGCOG1166.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-49-MONOMER.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_PROMA
AccessionPrimary (citable) accession number: Q7VEG4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families