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Q7VED2

- DEF_PROMA

UniProt

Q7VED2 - DEF_PROMA

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Protein

Peptide deformylase

Gene

def

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211IronUniRule annotation
Metal bindingi163 – 1631IronUniRule annotation
Active sitei164 – 1641UniRule annotation
Metal bindingi167 – 1671IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-83-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:Pro_0081
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Peptide deformylasePRO_0000082815Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro0081.

Structurei

3D structure databases

ProteinModelPortaliQ7VED2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiMEMVFYP.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VED2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSFSQLAI NAEKQRTSLA VSKKPTDQPE LEIHTLGNSA LRQSAKRISK
60 70 80 90 100
VDKNIRDLVK KMLHSMYAAK GIGLAAPQIG SQQQLLVIDL DIENSATPPI
110 120 130 140 150
ILINPEITEF SATIDTYEEG CLSIPGVYLD VIRPSSIKVN FRDEMGRPKK
160 170 180 190 200
INADGLLARC IQHEMDHLNG VLFVDRAINE EALNKELKEH GFKKKDVLRL

CSD
Length:203
Mass (Da):22,616
Last modified:October 1, 2003 - v1
Checksum:i8A792D21DFF8EDAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAP99127.1.
RefSeqiNP_874475.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAP99127; AAP99127; Pro_0081.
GeneIDi1461460.
KEGGipma:Pro_0081.
PATRICi23026741. VBIProMar8617_0085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAP99127.1 .
RefSeqi NP_874475.1. NC_005042.1.

3D structure databases

ProteinModelPortali Q7VED2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167539.Pro0081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP99127 ; AAP99127 ; Pro_0081 .
GeneIDi 1461460.
KEGGi pma:Pro_0081.
PATRICi 23026741. VBIProMar8617_0085.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi MEMVFYP.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci PMAR167539:GJN2-83-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SARG / CCMP1375 / SS120.

Entry informationi

Entry nameiDEF_PROMA
AccessioniPrimary (citable) accession number: Q7VED2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3