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Q7VE34

- NADK1_PROMA

UniProt

Q7VE34 - NADK1_PROMA

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Protein
NAD kinase 1
Gene
nadK1, Pro_0180
Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptor By similarity
Binding sitei179 – 1791NAD By similarity
Binding sitei181 – 1811NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NAD By similarity
Nucleotide bindingi149 – 1502NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-183-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 1
Gene namesi
Name:nadK1
Ordered Locus Names:Pro_0180
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001420: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307NAD kinase 1UniRule annotation
PRO_0000229666Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro0180.

Structurei

3D structure databases

ProteinModelPortaliQ7VE34.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VE34-1 [UniParc]FASTAAdd to Basket

« Hide

MKLELIWVIY KSGSKSAKEE ALLCSRNIES LGIKVITAES GPLLNTCNNI    50
LNPNKQIPTL VIVLGGDGTV LGAARHLAMY EVPILSFNVG GNLGFLTHDR 100
QLLKDESLWS RIQEDQFAIE SRMMLKGRVE SYLDTNDVGK KENFFWALND 150
IYFRSCSEDI SPTCTLELKI DDEDVDIYRG DGVILSTPTG STAYSMATGG 200
PILHPGIEAI IVSAICPMSL SSRPIVVPAG SRLIIKPVGN KNQRVNIWQD 250
GVSSALMQKG EQCVIEKARN HAQMLILEQS PSYFRTLTQK LHWAGSLVDN 300
QNKMAPK 307
Length:307
Mass (Da):33,863
Last modified:October 1, 2003 - v1
Checksum:i42FF774A5E582438
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAP99226.1.
RefSeqiNP_874574.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAP99226; AAP99226; Pro_0180.
GeneIDi1461559.
KEGGipma:Pro_0180.
PATRICi23026947. VBIProMar8617_0187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAP99226.1 .
RefSeqi NP_874574.1. NC_005042.1.

3D structure databases

ProteinModelPortali Q7VE34.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167539.Pro0180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP99226 ; AAP99226 ; Pro_0180 .
GeneIDi 1461559.
KEGGi pma:Pro_0180.
PATRICi 23026947. VBIProMar8617_0187.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PMAR167539:GJN2-183-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SARG / CCMP1375 / SS120.

Entry informationi

Entry nameiNADK1_PROMA
AccessioniPrimary (citable) accession number: Q7VE34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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