Reviewed, UniProtKB/Swiss-Prot Q7VE34 (PPNK1_PROMA)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 1
      Short name=Poly(P)/ATP NAD kinase 1
    EC=2.7.1.23

Gene names

Name:	ppnK1
Ordered Locus Names:	Pro_0180

Organism

Prochlorococcus marinus [Complete proteome] [HAMAP]

Taxonomic identifier

1219 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Probable inorganic polyphosphate/ATP-NAD kinase 1 HAMAP MF_00361		PRO_0000229666

Sequences

	Sequence		Length	Mass (Da)
	Q7VE34-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 42FF774A5E582438	FASTA	307	33,863
	10 20 30 40 50 60 MKLELIWVIY KSGSKSAKEE ALLCSRNIES LGIKVITAES GPLLNTCNNI LNPNKQIPTL 70 80 90 100 110 120 VIVLGGDGTV LGAARHLAMY EVPILSFNVG GNLGFLTHDR QLLKDESLWS RIQEDQFAIE 130 140 150 160 170 180 SRMMLKGRVE SYLDTNDVGK KENFFWALND IYFRSCSEDI SPTCTLELKI DDEDVDIYRG 190 200 210 220 230 240 DGVILSTPTG STAYSMATGG PILHPGIEAI IVSAICPMSL SSRPIVVPAG SRLIIKPVGN 250 260 270 280 290 300 KNQRVNIWQD GVSSALMQKG EQCVIEKARN HAQMLILEQS PSYFRTLTQK LHWAGSLVDN QNKMAPK

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed: 12917486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017126 Genomic DNA. Translation: AAP99226.1.
RefSeq	NP_874574.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1461559.
GenomeReviews	Gene locus Pro_0180 in contig AE017126_GR.
KEGG	pma:Pro0180.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VE34.
OMA	KLHWAGS.
Enzyme and pathway databases
BioCyc	PMAR167539:PRO_0180-MON.
BRENDA	2.7.1.23. 141456.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK1_PROMA

Accession

Primary (citable) accession number: Q7VE34

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)