Q7VDV6 (PYRB_PROMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Pro_0262

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Taxonomic identifier

167539 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113173

Sequences

	Sequence		Length	Mass (Da)
	Q7VDV6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 49A832EF930A5C6C	FASTA	338	37,154
	10 20 30 40 50 60 MSNWSHKHIL DLSSFSIEDY QTVVELANRF KTIPRSGSRK LPALQGRLIA TLFFEPSTRT 70 80 90 100 110 120 RSSFELAAKR LSADVQSFAP SNSSLIKGET PLDTVMTYVA MGAHVLVVRH GGTGVPEQLA 130 140 150 160 170 180 KSLDQKKKNV SILNGGDGLH SHPSQGLLDL FTLTQFFNKE SPSPRNIAGK RIAIVGDILH 190 200 210 220 230 240 SRVARSNLWS LTACGANVVL CGPPSLLPDD FAKFVEAPPS GQKKDPIKNR GKVTISRCLK 250 260 270 280 290 300 EALTDTDAVI TLRLQKERMS ENLLSNLDKY HNEYGITHES LKWCGKHVPV LHPGPVNRGI 310 320 330 EMSSELLEDN SISLIENQVS NGIPIRMALL YLLSADKN

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed: 12917486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017126 Genomic DNA. Translation: AAP99308.1.
RefSeq	NP_874656.1. NC_005042.1.
3D structure databases
ProteinModelPortal	Q7VDV6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1461641.
GenomeReviews	Gene locus Pro_0262 in contig AE017126_GR.
KEGG	pma:Pro0262.
PATRIC	23027113. VBIProMar8617_0270.
Phylogenomic databases
HOGENOM	HBG579429.
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	PMAR167539:PRO_0262-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_PROMA

Accession

Primary (citable) accession number: Q7VDV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program