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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase (mtnP)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31PhosphateUniRule annotation1
Sitei189Important for substrate specificityUniRule annotation1
Binding sitei207Substrate; via amide nitrogenUniRule annotation1
Binding sitei208PhosphateUniRule annotation1
Sitei244Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-338-MONOMER
UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:Pro_0332
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004150971 – 314S-methyl-5'-thioadenosine phosphorylaseAdd BLAST314

Proteomic databases

PRIDEiQ7VDN6

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi167539.Pro0332

Structurei

3D structure databases

ProteinModelPortaliQ7VDN6
SMRiQ7VDN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 74Phosphate bindingUniRule annotation2
Regioni106 – 107Phosphate bindingUniRule annotation2
Regioni231 – 233Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RHB Bacteria
COG0005 LUCA
KOiK00772
OMAiNLYRSWG
OrthoDBiPOG091H0228

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VDN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKHFSSEE IEQDGKSCLL KNARLGVLGG SGLYSIDSIE NIKELDIETP
60 70 80 90 100
YGKPSDSLRI GNLGGMEVVF LARHGRHHIY TPTEIPYRAN IWALRSLNVR
110 120 130 140 150
WILSPSAVGS LQEQVRPLDM VVPDQFIDRT HQRPLTFFCD GAVAHVTMAD
160 170 180 190 200
PFCPTLSRLL AEEGELLMPE ARQVHKGGTY LAMEGPAFST RAESQLYRSW
210 220 230 240 250
GCKVIGMTNH TEARLAREAE IAYTSLSMVT DYDCWHEGFG NVSVDLVIEN
260 270 280 290 300
LAANAKLASK IVEATAKRIS KLLPPSEAHT ALKNSLMTSK DKVSETTREK
310
INLFTENYWG KFNK
Length:314
Mass (Da):35,041
Last modified:October 1, 2003 - v1
Checksum:i2E6812A63C762E3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAP99378.1
RefSeqiNP_874726.1, NC_005042.1
WP_011124487.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAP99378; AAP99378; Pro_0332
GeneIDi1461711
KEGGipma:Pro_0332
PATRICifig|167539.5.peg.341

Similar proteinsi

Entry informationi

Entry nameiMTAP_PROMA
AccessioniPrimary (citable) accession number: Q7VDN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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