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Q7VCK5 (UPPP_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:Pro_0735
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151178

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane56 – 7621Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane269 – 28921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7VCK5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5F4321C833A658E9

FASTA28931,950
        10         20         30         40         50         60 
MVLLAVGELS ASLSLLEECW HYLFLGIIQG LTEFFPISST AHLKVIPLLL SWDDPGVAVT 

        70         80         90        100        110        120 
ASLQLGSIIA LIAYFWNDLA FLMRGISKAS FQNSWNNQNT KLASAIVLGT LPIVFAGMLI 

       130        140        150        160        170        180 
KLFWQGYETS PIRSIPAIAV VSIVMALLLL IAENVGRRTR NFENLSFWDG QIIGFSQVLA 

       190        200        210        220        230        240 
LIPGVSRSGI TITTALMIGW ERKSAARFSF LLGIPAITLA GLVELKQAFG SFELVDVFPL 

       250        260        270        280 
LLGITSSAIS SWIAIDCLMK FLQTQSMMIF ITYRFLFGTL LLFWYYLAF 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAP99779.1.
RefSeqNP_875127.1. NC_005042.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro0735.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP99779; AAP99779; Pro_0735.
GeneID1462117.
KEGGpma:Pro_0735.
PATRIC23028165. VBIProMar8617_0777.

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-757-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PROMA
AccessionPrimary (citable) accession number: Q7VCK5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families