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Q7VBZ5

- SYL_PROMA

UniProt

Q7VBZ5 - SYL_PROMA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei629 – 6291ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167539:GJN2-973-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Pro_0947
    OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
    Taxonomic identifieri167539 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001420: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Leucine--tRNA ligasePRO_0000152063Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167539.Pro0947.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VBZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi55 – 6511"HIGH" regionAdd
    BLAST
    Motifi626 – 6305"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VBZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKISQTPE KQPSTAYDPL SIETRWQQSW KEQGLYKTKE PTKSQKTFYA    50
    LSMFPYPSGT LHMGHVRNYV ITDVIARLHR MKGDSVLHPM GWDAFGLPAE 100
    NAAIERGIPA DIWTYKNIED MRNQLNRLGL SIDWDKEVTT CKEEYYKWTQ 150
    YIFLELYEAG LAYQKSATVN WDPIDKTVLA NEQVDANGRS WRSGALVEKK 200
    KLKQWFLKIT DFADELLEDI ELLSGWPQNV KTMQQNWIGR SNGTEIDFYI 250
    KGKNNIFITV FTTRPDTLHG TEYLVLAPDH ELINSIIDKN KITELEQFRT 300
    EISILTDQER TSDGNNKRGM FLGCHAINPI NKKIIPIWVG EYVLSSYATG 350
    AVMGVPAHDK RDYKFAKKYS LPIQYVIKSP SQEASDLEAS SAYVKEGIMI 400
    NSGEFNGINS KEAGFMITKL GVKQGWAKNK VTYKLRDWLI SRQRMWGCPI 450
    PIIYCPDCGS VPVKREELPV KLTNPSVIGK SQENKNNIPI MKCSKCNKDS 500
    ILETDTMDTF MCSSWYFLRY IDVENNKLPF TKTEVDKWLP VDQYVGGIEH 550
    AILHLLYSRF LIKALRNRGL LNIKEPFSNL LTQGMVQGVT FKNPKTSKYI 600
    SPDHINDINT PLDPETGEPL DVLYEKMSKS KYNGVDPASV IDKYGTDTAR 650
    MFILFKAPPE KDLEWDESDV EGQYRFLNRL WRIVIYSIET KDINISNCTQ 700
    EILLNDLSDK ERKLIKVLNN TIKEVTNDLV NDFQFNTAIS ELMILCNSIY 750
    ENIDDCGDYI VTETFKKLTL LLAPFAPHIA EEFWIKLKGK GSVHENSWPT 800
    YDPKALLEDS YKLIIQINGK VRGNISVNHE DSELELKNKA LACETTQKWL 850
    NGIEPKRIII VKGKIINIVF 870
    Length:870
    Mass (Da):99,805
    Last modified:October 1, 2003 - v1
    Checksum:i673DF65DC039FA7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAP99991.1.
    RefSeqiNP_875339.1. NC_005042.1.
    WP_011125099.1. NC_005042.1.

    Genome annotation databases

    EnsemblBacteriaiAAP99991; AAP99991; Pro_0947.
    GeneIDi1462329.
    KEGGipma:Pro_0947.
    PATRICi23028609. VBIProMar8617_0996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAP99991.1 .
    RefSeqi NP_875339.1. NC_005042.1.
    WP_011125099.1. NC_005042.1.

    3D structure databases

    ProteinModelPortali Q7VBZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167539.Pro0947.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP99991 ; AAP99991 ; Pro_0947 .
    GeneIDi 1462329.
    KEGGi pma:Pro_0947.
    PATRICi 23028609. VBIProMar8617_0996.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMAR167539:GJN2-973-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SARG / CCMP1375 / SS120.

    Entry informationi

    Entry nameiSYL_PROMA
    AccessioniPrimary (citable) accession number: Q7VBZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3