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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei629ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-973-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pro_0947
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520631 – 870Leucine--tRNA ligaseAdd BLAST870

Proteomic databases

PRIDEiQ7VBZ5

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro0947

Structurei

3D structure databases

ProteinModelPortaliQ7VBZ5
SMRiQ7VBZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 65"HIGH" regionAdd BLAST11
Motifi626 – 630"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VBZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKISQTPE KQPSTAYDPL SIETRWQQSW KEQGLYKTKE PTKSQKTFYA
60 70 80 90 100
LSMFPYPSGT LHMGHVRNYV ITDVIARLHR MKGDSVLHPM GWDAFGLPAE
110 120 130 140 150
NAAIERGIPA DIWTYKNIED MRNQLNRLGL SIDWDKEVTT CKEEYYKWTQ
160 170 180 190 200
YIFLELYEAG LAYQKSATVN WDPIDKTVLA NEQVDANGRS WRSGALVEKK
210 220 230 240 250
KLKQWFLKIT DFADELLEDI ELLSGWPQNV KTMQQNWIGR SNGTEIDFYI
260 270 280 290 300
KGKNNIFITV FTTRPDTLHG TEYLVLAPDH ELINSIIDKN KITELEQFRT
310 320 330 340 350
EISILTDQER TSDGNNKRGM FLGCHAINPI NKKIIPIWVG EYVLSSYATG
360 370 380 390 400
AVMGVPAHDK RDYKFAKKYS LPIQYVIKSP SQEASDLEAS SAYVKEGIMI
410 420 430 440 450
NSGEFNGINS KEAGFMITKL GVKQGWAKNK VTYKLRDWLI SRQRMWGCPI
460 470 480 490 500
PIIYCPDCGS VPVKREELPV KLTNPSVIGK SQENKNNIPI MKCSKCNKDS
510 520 530 540 550
ILETDTMDTF MCSSWYFLRY IDVENNKLPF TKTEVDKWLP VDQYVGGIEH
560 570 580 590 600
AILHLLYSRF LIKALRNRGL LNIKEPFSNL LTQGMVQGVT FKNPKTSKYI
610 620 630 640 650
SPDHINDINT PLDPETGEPL DVLYEKMSKS KYNGVDPASV IDKYGTDTAR
660 670 680 690 700
MFILFKAPPE KDLEWDESDV EGQYRFLNRL WRIVIYSIET KDINISNCTQ
710 720 730 740 750
EILLNDLSDK ERKLIKVLNN TIKEVTNDLV NDFQFNTAIS ELMILCNSIY
760 770 780 790 800
ENIDDCGDYI VTETFKKLTL LLAPFAPHIA EEFWIKLKGK GSVHENSWPT
810 820 830 840 850
YDPKALLEDS YKLIIQINGK VRGNISVNHE DSELELKNKA LACETTQKWL
860 870
NGIEPKRIII VKGKIINIVF
Length:870
Mass (Da):99,805
Last modified:October 1, 2003 - v1
Checksum:i673DF65DC039FA7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAP99991.1
RefSeqiNP_875339.1, NC_005042.1
WP_011125099.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAP99991; AAP99991; Pro_0947
GeneIDi1462329
KEGGipma:Pro_0947
PATRICifig|167539.5.peg.996

Similar proteinsi

Entry informationi

Entry nameiSYL_PROMA
AccessioniPrimary (citable) accession number: Q7VBZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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