Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7VBZ5 (SYL_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Pro_0947
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length870 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 870870Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152063

Regions

Motif55 – 6511"HIGH" region HAMAP-Rule MF_00049
Motif626 – 6305"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6291ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VBZ5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 673DF65DC039FA7C

FASTA87099,805
        10         20         30         40         50         60 
MASKISQTPE KQPSTAYDPL SIETRWQQSW KEQGLYKTKE PTKSQKTFYA LSMFPYPSGT 

        70         80         90        100        110        120 
LHMGHVRNYV ITDVIARLHR MKGDSVLHPM GWDAFGLPAE NAAIERGIPA DIWTYKNIED 

       130        140        150        160        170        180 
MRNQLNRLGL SIDWDKEVTT CKEEYYKWTQ YIFLELYEAG LAYQKSATVN WDPIDKTVLA 

       190        200        210        220        230        240 
NEQVDANGRS WRSGALVEKK KLKQWFLKIT DFADELLEDI ELLSGWPQNV KTMQQNWIGR 

       250        260        270        280        290        300 
SNGTEIDFYI KGKNNIFITV FTTRPDTLHG TEYLVLAPDH ELINSIIDKN KITELEQFRT 

       310        320        330        340        350        360 
EISILTDQER TSDGNNKRGM FLGCHAINPI NKKIIPIWVG EYVLSSYATG AVMGVPAHDK 

       370        380        390        400        410        420 
RDYKFAKKYS LPIQYVIKSP SQEASDLEAS SAYVKEGIMI NSGEFNGINS KEAGFMITKL 

       430        440        450        460        470        480 
GVKQGWAKNK VTYKLRDWLI SRQRMWGCPI PIIYCPDCGS VPVKREELPV KLTNPSVIGK 

       490        500        510        520        530        540 
SQENKNNIPI MKCSKCNKDS ILETDTMDTF MCSSWYFLRY IDVENNKLPF TKTEVDKWLP 

       550        560        570        580        590        600 
VDQYVGGIEH AILHLLYSRF LIKALRNRGL LNIKEPFSNL LTQGMVQGVT FKNPKTSKYI 

       610        620        630        640        650        660 
SPDHINDINT PLDPETGEPL DVLYEKMSKS KYNGVDPASV IDKYGTDTAR MFILFKAPPE 

       670        680        690        700        710        720 
KDLEWDESDV EGQYRFLNRL WRIVIYSIET KDINISNCTQ EILLNDLSDK ERKLIKVLNN 

       730        740        750        760        770        780 
TIKEVTNDLV NDFQFNTAIS ELMILCNSIY ENIDDCGDYI VTETFKKLTL LLAPFAPHIA 

       790        800        810        820        830        840 
EEFWIKLKGK GSVHENSWPT YDPKALLEDS YKLIIQINGK VRGNISVNHE DSELELKNKA 

       850        860        870 
LACETTQKWL NGIEPKRIII VKGKIINIVF 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAP99991.1.
RefSeqNP_875339.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7VBZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro0947.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP99991; AAP99991; Pro_0947.
GeneID1462329.
KEGGpma:Pro_0947.
PATRIC23028609. VBIProMar8617_0996.

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-973-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PROMA
AccessionPrimary (citable) accession number: Q7VBZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries