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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei629 – 6291ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Pro_0947
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Leucine--tRNA ligasePRO_0000152063Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro0947.

Structurei

3D structure databases

ProteinModelPortaliQ7VBZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 6511"HIGH" regionAdd
BLAST
Motifi626 – 6305"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VBZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKISQTPE KQPSTAYDPL SIETRWQQSW KEQGLYKTKE PTKSQKTFYA
60 70 80 90 100
LSMFPYPSGT LHMGHVRNYV ITDVIARLHR MKGDSVLHPM GWDAFGLPAE
110 120 130 140 150
NAAIERGIPA DIWTYKNIED MRNQLNRLGL SIDWDKEVTT CKEEYYKWTQ
160 170 180 190 200
YIFLELYEAG LAYQKSATVN WDPIDKTVLA NEQVDANGRS WRSGALVEKK
210 220 230 240 250
KLKQWFLKIT DFADELLEDI ELLSGWPQNV KTMQQNWIGR SNGTEIDFYI
260 270 280 290 300
KGKNNIFITV FTTRPDTLHG TEYLVLAPDH ELINSIIDKN KITELEQFRT
310 320 330 340 350
EISILTDQER TSDGNNKRGM FLGCHAINPI NKKIIPIWVG EYVLSSYATG
360 370 380 390 400
AVMGVPAHDK RDYKFAKKYS LPIQYVIKSP SQEASDLEAS SAYVKEGIMI
410 420 430 440 450
NSGEFNGINS KEAGFMITKL GVKQGWAKNK VTYKLRDWLI SRQRMWGCPI
460 470 480 490 500
PIIYCPDCGS VPVKREELPV KLTNPSVIGK SQENKNNIPI MKCSKCNKDS
510 520 530 540 550
ILETDTMDTF MCSSWYFLRY IDVENNKLPF TKTEVDKWLP VDQYVGGIEH
560 570 580 590 600
AILHLLYSRF LIKALRNRGL LNIKEPFSNL LTQGMVQGVT FKNPKTSKYI
610 620 630 640 650
SPDHINDINT PLDPETGEPL DVLYEKMSKS KYNGVDPASV IDKYGTDTAR
660 670 680 690 700
MFILFKAPPE KDLEWDESDV EGQYRFLNRL WRIVIYSIET KDINISNCTQ
710 720 730 740 750
EILLNDLSDK ERKLIKVLNN TIKEVTNDLV NDFQFNTAIS ELMILCNSIY
760 770 780 790 800
ENIDDCGDYI VTETFKKLTL LLAPFAPHIA EEFWIKLKGK GSVHENSWPT
810 820 830 840 850
YDPKALLEDS YKLIIQINGK VRGNISVNHE DSELELKNKA LACETTQKWL
860 870
NGIEPKRIII VKGKIINIVF
Length:870
Mass (Da):99,805
Last modified:October 1, 2003 - v1
Checksum:i673DF65DC039FA7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA. Translation: AAP99991.1.
RefSeqiNP_875339.1. NC_005042.1.
WP_011125099.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAP99991; AAP99991; Pro_0947.
GeneIDi1462329.
KEGGipma:Pro_0947.
PATRICi23028609. VBIProMar8617_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA. Translation: AAP99991.1.
RefSeqiNP_875339.1. NC_005042.1.
WP_011125099.1. NC_005042.1.

3D structure databases

ProteinModelPortaliQ7VBZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167539.Pro0947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP99991; AAP99991; Pro_0947.
GeneIDi1462329.
KEGGipma:Pro_0947.
PATRICi23028609. VBIProMar8617_0996.

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-973-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SARG / CCMP1375 / SS120.

Entry informationi

Entry nameiSYL_PROMA
AccessioniPrimary (citable) accession number: Q7VBZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.