Q7VBF8 (Q7VBF8_PROMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL AAQ00182.1
Ordered Locus Names:	Pro_1137

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Taxonomic identifier

167539 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	875 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS013760 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7VBF8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 80E989D5C3B512C5	FASTA	875	96,965
	10 20 30 40 50 60 MFCMADPTEP TGGVPDELED RIIQTDLRNE MSRSYLEYAM SVIVGRALPD ARDGLKPVHR 70 80 90 100 110 120 RILYAMYELG LTSDRPYRKC ARVVGEVLGK YHPHGDTAVY DALVRMAQDF SMQMPLIDGH 130 140 150 160 170 180 GNFGSIDNDP PAAMRYTESR LRSLTQDSLL EDIESETVDF IDNFDGSQQE PTVLPARIPQ 190 200 210 220 230 240 LLLNGSSGIA VGMATNIPPH NLGELIDGLM ALIANPDLND QEIMKIIPGP DFPTGGQILG 250 260 270 280 290 300 RSGIRETYLS GRGSVTMRGV AEIETLEIPG RPDRDAIIIT QLPYQTNKAA LIERIAYMVN 310 320 330 340 350 360 DKKLEGISDI RDESDRDGMR IVVELRRDSY PQVVLNNLFK LTPLQSNFSA NMLALVDGEP 370 380 390 400 410 420 ITLSLLRMLN VFLDFRVITI EKRTKYLLRK AEERNHLLLG LLLALDQLDE IIALIRSASD 430 440 450 460 470 480 TSVAKKQLQE IHGLTDVQAD AILQMQLRRL TALESDKIRL EHEDLLVKIS DFKDILSNKS 490 500 510 520 530 540 RVYEIIKTEL ISIKEKFPQV RRTEILDLGS GLEDIDLIAN ERSVVLLTET GYLKRMPVNE 550 560 570 580 590 600 FEATSRGTRG KSGTRSQGEE EVKLFISCND HDNLLLFSVR GVSYSVPAYR VPQCSRAAKG 610 620 630 640 650 660 TPVVQLLPIP REESITSLIS VSSFDDDNYL LMLTIGGFIK RTPVSAFSKI RANGLISINL 670 680 690 700 710 720 EDGDALRWVR LASSADSVLI GSKAGMTIHF RLNDNELRPL GRTARGVRSM NLRDGDSLVS 730 740 750 760 770 780 MDVLSKELAD RIASTNDDEA INSNGQYEGP WILVASADGL GKRVPVTQFR LQKRSGMGLR 790 800 810 820 830 840 AMKFRSDTDE LVGLKVLDKG EEVLLVSEKG VIVRTSADKI SQQSRAATGV RLQRLDSGDH 850 860 870 LSEIVLVPPQ LADEEVNSDS LSSNSDSGAD TPPKD

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed: 12917486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017126 Genomic DNA. Translation: AAQ00182.1.
RefSeq	NP_875529.1. NC_005042.1.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortal	Q7VBF8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1462519.
GenomeReviews	Gene locus Pro_1137 in contig AE017126_GR.
KEGG	pma:Pro1137.
PATRIC	23028999. VBIProMar8617_1189.
Phylogenomic databases
HOGENOM	HBG635183.
OMA	TSIPPHR.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	PMAR167539:PRO_1137-MONOMER.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 2 hits.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q7VBF8_PROMA

Accession

Primary (citable) accession number: Q7VBF8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)