SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7VAW0

- NADK2_PROMA

UniProt

Q7VAW0 - NADK2_PROMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase 2

Gene
nadK2, Pro_1343
Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781Proton acceptor By similarity
Binding sitei182 – 1821NAD By similarity
Binding sitei217 – 2171NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 792NAD By similarity
Nucleotide bindingi152 – 1532NAD By similarity
Nucleotide bindingi193 – 1986NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-1373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 2
Gene namesi
Name:nadK2
Ordered Locus Names:Pro_1343
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001420: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302NAD kinase 2UniRule annotationPRO_0000229667Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro1343.

Structurei

3D structure databases

ProteinModelPortaliQ7VAW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiRWEALCL.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VAW0-1 [UniParc]FASTAAdd to Basket

« Hide

MPRLGLILND GKELALKAAL SIESKLEKSG YEVVRVSSSG GMVGFANPDQ    50
HMRTLGYNAC VPEGFDPSMK LAIVLGGDGT VLSAARQTAP VGVPILTINT 100
GHLGFLSEAY LPDIDKALEQ VLASQWEIEE RTSLVVSVMR GEQRRWEALC 150
LNEMALHREP LTSMCHFEIS IGRHAPVDIS ADGVILSTPT GSTAYSLSAG 200
GPVITPDCPV LQLTPIAPHS LASRALVFSD LEPVTVFPAT PERLMMVVDG 250
TAGCYVWPED RVLIRKSNHP VRFIRLTDHE FFQVLRKKLG WGLPHVAKPE 300
KY 302
Length:302
Mass (Da):32,889
Last modified:October 1, 2003 - v1
Checksum:i4A319B1CA956C5F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAQ00387.1.
RefSeqiNP_875734.1. NC_005042.1.
WP_011125494.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAQ00387; AAQ00387; Pro_1343.
GeneIDi1462724.
KEGGipma:Pro_1343.
PATRICi23029443. VBIProMar8617_1408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAQ00387.1 .
RefSeqi NP_875734.1. NC_005042.1.
WP_011125494.1. NC_005042.1.

3D structure databases

ProteinModelPortali Q7VAW0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167539.Pro1343.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ00387 ; AAQ00387 ; Pro_1343 .
GeneIDi 1462724.
KEGGi pma:Pro_1343.
PATRICi 23029443. VBIProMar8617_1408.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi RWEALCL.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PMAR167539:GJN2-1373-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SARG / CCMP1375 / SS120.

Entry informationi

Entry nameiNADK2_PROMA
AccessioniPrimary (citable) accession number: Q7VAW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi