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Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78Proton acceptorUniRule annotation1
Binding sitei182NADUniRule annotation1
Binding sitei217NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 79NADUniRule annotation2
Nucleotide bindingi152 – 153NADUniRule annotation2
Nucleotide bindingi193 – 198NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-1373-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:Pro_1343
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296671 – 302NAD kinase 2Add BLAST302

Proteomic databases

PRIDEiQ7VAW0

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro1343

Structurei

3D structure databases

ProteinModelPortaliQ7VAW0
SMRiQ7VAW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VAW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLGLILND GKELALKAAL SIESKLEKSG YEVVRVSSSG GMVGFANPDQ
60 70 80 90 100
HMRTLGYNAC VPEGFDPSMK LAIVLGGDGT VLSAARQTAP VGVPILTINT
110 120 130 140 150
GHLGFLSEAY LPDIDKALEQ VLASQWEIEE RTSLVVSVMR GEQRRWEALC
160 170 180 190 200
LNEMALHREP LTSMCHFEIS IGRHAPVDIS ADGVILSTPT GSTAYSLSAG
210 220 230 240 250
GPVITPDCPV LQLTPIAPHS LASRALVFSD LEPVTVFPAT PERLMMVVDG
260 270 280 290 300
TAGCYVWPED RVLIRKSNHP VRFIRLTDHE FFQVLRKKLG WGLPHVAKPE

KY
Length:302
Mass (Da):32,889
Last modified:October 1, 2003 - v1
Checksum:i4A319B1CA956C5F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAQ00387.1
RefSeqiNP_875734.1, NC_005042.1
WP_011125494.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAQ00387; AAQ00387; Pro_1343
GeneIDi1462724
KEGGipma:Pro_1343
PATRICifig|167539.5.peg.1408

Similar proteinsi

Entry informationi

Entry nameiNADK2_PROMA
AccessioniPrimary (citable) accession number: Q7VAW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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