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Q7VAW0

- NADK2_PROMA

UniProt

Q7VAW0 - NADK2_PROMA

Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei78 – 781Proton acceptorUniRule annotation
    Binding sitei182 – 1821NADUniRule annotation
    Binding sitei217 – 2171NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 792NADUniRule annotation
    Nucleotide bindingi152 – 1532NADUniRule annotation
    Nucleotide bindingi193 – 1986NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167539:GJN2-1373-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:Pro_1343
    OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
    Taxonomic identifieri167539 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001420: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302NAD kinase 2PRO_0000229667Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167539.Pro1343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VAW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiRWEALCL.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VAW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRLGLILND GKELALKAAL SIESKLEKSG YEVVRVSSSG GMVGFANPDQ    50
    HMRTLGYNAC VPEGFDPSMK LAIVLGGDGT VLSAARQTAP VGVPILTINT 100
    GHLGFLSEAY LPDIDKALEQ VLASQWEIEE RTSLVVSVMR GEQRRWEALC 150
    LNEMALHREP LTSMCHFEIS IGRHAPVDIS ADGVILSTPT GSTAYSLSAG 200
    GPVITPDCPV LQLTPIAPHS LASRALVFSD LEPVTVFPAT PERLMMVVDG 250
    TAGCYVWPED RVLIRKSNHP VRFIRLTDHE FFQVLRKKLG WGLPHVAKPE 300
    KY 302
    Length:302
    Mass (Da):32,889
    Last modified:October 1, 2003 - v1
    Checksum:i4A319B1CA956C5F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAQ00387.1.
    RefSeqiNP_875734.1. NC_005042.1.
    WP_011125494.1. NC_005042.1.

    Genome annotation databases

    EnsemblBacteriaiAAQ00387; AAQ00387; Pro_1343.
    GeneIDi1462724.
    KEGGipma:Pro_1343.
    PATRICi23029443. VBIProMar8617_1408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAQ00387.1 .
    RefSeqi NP_875734.1. NC_005042.1.
    WP_011125494.1. NC_005042.1.

    3D structure databases

    ProteinModelPortali Q7VAW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167539.Pro1343.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ00387 ; AAQ00387 ; Pro_1343 .
    GeneIDi 1462724.
    KEGGi pma:Pro_1343.
    PATRICi 23029443. VBIProMar8617_1408.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi RWEALCL.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci PMAR167539:GJN2-1373-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SARG / CCMP1375 / SS120.

    Entry informationi

    Entry nameiNADK2_PROMA
    AccessioniPrimary (citable) accession number: Q7VAW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3