Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78Proton acceptorUniRule annotation1
Binding sitei182NADUniRule annotation1
Binding sitei217NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 79NADUniRule annotation2
Nucleotide bindingi152 – 153NADUniRule annotation2
Nucleotide bindingi193 – 198NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:Pro_1343
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296671 – 302NAD kinase 2Add BLAST302

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro1343.

Structurei

3D structure databases

ProteinModelPortaliQ7VAW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiMCHFEIA.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VAW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLGLILND GKELALKAAL SIESKLEKSG YEVVRVSSSG GMVGFANPDQ
60 70 80 90 100
HMRTLGYNAC VPEGFDPSMK LAIVLGGDGT VLSAARQTAP VGVPILTINT
110 120 130 140 150
GHLGFLSEAY LPDIDKALEQ VLASQWEIEE RTSLVVSVMR GEQRRWEALC
160 170 180 190 200
LNEMALHREP LTSMCHFEIS IGRHAPVDIS ADGVILSTPT GSTAYSLSAG
210 220 230 240 250
GPVITPDCPV LQLTPIAPHS LASRALVFSD LEPVTVFPAT PERLMMVVDG
260 270 280 290 300
TAGCYVWPED RVLIRKSNHP VRFIRLTDHE FFQVLRKKLG WGLPHVAKPE

KY
Length:302
Mass (Da):32,889
Last modified:October 1, 2003 - v1
Checksum:i4A319B1CA956C5F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA. Translation: AAQ00387.1.
RefSeqiNP_875734.1. NC_005042.1.
WP_011125494.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAQ00387; AAQ00387; Pro_1343.
GeneIDi1462724.
KEGGipma:Pro_1343.
PATRICi23029443. VBIProMar8617_1408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA. Translation: AAQ00387.1.
RefSeqiNP_875734.1. NC_005042.1.
WP_011125494.1. NC_005042.1.

3D structure databases

ProteinModelPortaliQ7VAW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167539.Pro1343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAQ00387; AAQ00387; Pro_1343.
GeneIDi1462724.
KEGGipma:Pro_1343.
PATRICi23029443. VBIProMar8617_1408.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiMCHFEIA.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK2_PROMA
AccessioniPrimary (citable) accession number: Q7VAW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.