Q7VAS9 (ARGD_PROMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylornithine aminotransferase
Short name=ACOAT
EC=2.6.1.11

Gene names

Name:	argD
Ordered Locus Names:	Pro_1375

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Taxonomic identifier

167539 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP MF_01107
Cofactor	Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_01107
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP MF_01107
Subunit structure	Homodimer By similarity. HAMAP MF_01107
Subcellular location	Cytoplasm Probable HAMAP MF_01107.
Miscellaneous	May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. HAMAP MF_01107
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
Sequence caution	The sequence AAQ00419.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Acetylornithine aminotransferase HAMAP MF_01107		PRO_0000112765
Regions
	Region	240 – 243	4	Pyridoxal phosphate binding By similarity
Sites
	Binding site	149	1	Pyridoxal phosphate; via carbonyl oxygen By similarity
	Binding site	152	1	N2-acetyl-L-ornithine By similarity
	Binding site	296	1	N2-acetyl-L-ornithine By similarity
	Binding site	297	1	Pyridoxal phosphate By similarity
Amino acid modifications
	Modified residue	269	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VAS9 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: DC0F95691ED5C975	FASTA	419	46,354
	10 20 30 40 50 60 MVDAPHSKCG TFGFVGSSPT APTFLLDTYK RLPLKIVKGN GCWLWDETGK KYLDAVAGIA 70 80 90 100 110 120 TCSLGHSDKK LSKVLSQQLR KIQHVSNLYR IPEQEDLAQW LVNQSCADSV FFCNSGAEAN 130 140 150 160 170 180 EAAIKLARKY GQIKRGIKRP IILSAKSSFH GRTLAALSAT GQTKYQKGFE PLVEGFEFFS 190 200 210 220 230 240 FNDSNSVQDL YENLEKDEPR VAAILIEPIQ GEGGLNLGDQ KFFYFLRDYC NKNNILLLFD 250 260 270 280 290 300 EVQSGMGRTG KLWGYEHFNV EPDAFTLAKG LGGGHSIGAL LVKENASIFE PGDHASTFGG 310 320 330 340 350 360 NPFACKAGLT VAKEIQNRNL LENTYCRGNQ LREGLQKLIN NYPHHLEEVR GIGLMLGLAI 370 380 390 400 410 KKNSNLTSQK IVELAIKEGL LVIGAGEKVI RMLPPLIITK REIETLLTRL NACFRKLNN

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed: 12917486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017126 Genomic DNA. Translation: AAQ00419.1. Different initiation.
RefSeq	NP_875766.1. NC_005042.1.
3D structure databases
ProteinModelPortal	Q7VAS9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1462756.
GenomeReviews	Gene locus Pro_1375 in contig AE017126_GR.
KEGG	pma:Pro1375.
PATRIC	23029515. VBIProMar8617_1442.
Phylogenomic databases
HOGENOM	HBG725944.
OMA	PLVMTKE.
ProtClustDB	PRK02627.
Enzyme and pathway databases
BioCyc	PMAR167539:PRO_1375-MONOMER.
Family and domain databases
HAMAP	MF_01107. ArgD_aminotrans_3. [Tree]
InterPro	IPR004636. AcOrn/SuccinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K00818.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF19. ArgD_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00707. ArgD. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGD_PROMA

Accession

Primary (citable) accession number: Q7VAS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program