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Q7VAS4 (DDL_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:Pro_1380
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177852

Regions

Domain141 – 349209ATP-grasp
Nucleotide binding176 – 23156ATP By similarity

Sites

Metal binding3021Magnesium or manganese 1 By similarity
Metal binding3161Magnesium or manganese 1 By similarity
Metal binding3161Magnesium or manganese 2 By similarity
Metal binding3181Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VAS4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2013FD642D1A43AB

FASTA35139,059
        10         20         30         40         50         60 
MRNAIKTVGI VFGGVSGEHE VSIKSARTII HALKHPININ KFDVISIYID KKGKWWPSEI 

        70         80         90        100        110        120 
AEKVLESDPN FDKNIFFKQV EFIGLDHLPK ETEKIQIWFP VLHGPNGEDG SIQGFFQLTG 

       130        140        150        160        170        180 
KPYVGSGVLG SALGMDKIAM KAAFSAAGLP QVNYCEIHSI DLLDKKRLSY LIQKIETQLG 

       190        200        210        220        230        240 
YPCFIKPANL GSSVGISKAY DKKELLNGLD LAAQLDSRIV VEKNIKAREL ECAVIGKKQI 

       250        260        270        280        290        300 
KTSCVGEVRY SSDWYDYDSK YSKNSTKTLI PAPIPEKISK EVQSLSILAC KAISAEGIAR 

       310        320        330        340        350 
VDFFYDEEKD SLWINEINTM PGFTEQSMYP MLWDASGIDI SQLVARLIES A 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAQ00424.1.
RefSeqNP_875771.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7VAS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro1380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ00424; AAQ00424; Pro_1380.
GeneID1462761.
KEGGpma:Pro_1380.
PATRIC23029527. VBIProMar8617_1447.

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-1413-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_PROMA
AccessionPrimary (citable) accession number: Q7VAS4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways