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Protein

Fumarate hydratase class II

Gene

fumC

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.UniRule annotation

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.UniRule annotation

Catalytic activityi

(S)-malate = fumarate + H2O.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Fumarate hydratase class II (fumC)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188SubstrateUniRule annotation1
Active sitei189Proton donor/acceptorUniRule annotation1
Active sitei319UniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Sitei332Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-1656-MONOMER
UniPathwayiUPA00223; UER01007

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class IIUniRule annotation (EC:4.2.1.2UniRule annotation)
Short name:
Fumarase CUniRule annotation
Alternative name(s):
Aerobic fumaraseUniRule annotation
Iron-independent fumaraseUniRule annotation
Gene namesi
Name:fumCUniRule annotation
Ordered Locus Names:Pro_1620
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001612961 – 465Fumarate hydratase class IIAdd BLAST465

Proteomic databases

PRIDEiQ7VA47

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi167539.Pro1620

Structurei

3D structure databases

ProteinModelPortaliQ7VA47
SMRiQ7VA47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 101Substrate bindingUniRule annotation3
Regioni130 – 133Substrate binding (B site)UniRule annotation4
Regioni140 – 142Substrate bindingUniRule annotation3
Regioni325 – 327Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9Q Bacteria
COG0114 LUCA
KOiK01679
OMAiVSFTDNC
OrthoDBiPOG091H01XG

Family and domain databases

CDDicd01362 Fumarase_classII, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00743 FumaraseC, 1 hit
InterProiView protein in InterPro
IPR005677 Fum_hydII
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR11444 PTHR11444, 1 hit
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VA47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSFRIEND SMGTIKVPDQ ALWGAQTQRS LINFAIGHNK MPMKLIYSIV
60 70 80 90 100
QIKASAAIVN CRLGVLDKQR KNFILNACNE ISNGMHDEQF PLSVWQTGSG
110 120 130 140 150
TQTNMNVNEV ISNIASHLNG NKLGSHEPLH PNDHVNRSQS TNDVFPAAIQ
160 170 180 190 200
IATVQEILEN LLPELDQLIE TFDKKIIKWN RIIKTGRTHL QDAVPLTLGQ
210 220 230 240 250
EASAWKEQLI ASRNRLNKSL NELYPLPLGG TAIGTGLNAP AKFDKEIALE
260 270 280 290 300
IAKSTRSPFV SAQNKFAIMA SHDALVHTMS QLKLLAVSLF KIVNDLRLLS
310 320 330 340 350
CGPRGGLGEL RLPENEPGSS IMPGKVNPTQ CEAMAMVCTQ IMALDSAVTM
360 370 380 390 400
AGSGGHLQMN SYKPLIAFNL LESIDLLSSA CKSSRILMIE GIEPNLEKIQ
410 420 430 440 450
NSLQNSLMLI TSLTPIIGYE KASKIAQCAH EKDITLKEAT KLLGYLNEDD
460
FDRIVNPQSM TGMEN
Length:465
Mass (Da):51,045
Last modified:October 1, 2003 - v1
Checksum:iF2F17242168FDA54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAQ00664.1
RefSeqiNP_876011.1, NC_005042.1
WP_011125770.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAQ00664; AAQ00664; Pro_1620
GeneIDi1463002
KEGGipma:Pro_1620
PATRICifig|167539.5.peg.1712

Similar proteinsi

Entry informationi

Entry nameiFUMC_PROMA
AccessioniPrimary (citable) accession number: Q7VA47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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