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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134NADUniRule annotation1
Binding sitei196NADUniRule annotation1
Binding sitei219NADUniRule annotation1
Binding sitei242SubstrateUniRule annotation1
Metal bindingi264ZincUniRule annotation1
Binding sitei264SubstrateUniRule annotation1
Metal bindingi267ZincUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei332Proton acceptorUniRule annotation1
Active sitei333Proton acceptorUniRule annotation1
Binding sitei333SubstrateUniRule annotation1
Metal bindingi366ZincUniRule annotation1
Binding sitei366SubstrateUniRule annotation1
Binding sitei420SubstrateUniRule annotation1
Metal bindingi425ZincUniRule annotation1
Binding sitei425SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-1679-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Pro_1643
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358131 – 440Histidinol dehydrogenaseAdd BLAST440

Proteomic databases

PRIDEiQ7VA26

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro1643

Structurei

3D structure databases

ProteinModelPortaliQ7VA26
SMRiQ7VA26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VA26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKQILNC IDDPQQALIM LKRISARTSL EVQENAISSV QNILTEVKQL
60 70 80 90 100
GDEALFRLTE KFDGFIPKPL EITPEQTLEA WEKTPTPLQE ALQLAKNRIE
110 120 130 140 150
AFHKYQIPKD FLKEGIHGEL LGKNWSPVEK AGIYIPGGRA AYPSTVLMNA
160 170 180 190 200
VPALVAGVNE IIMVSPAGPN GQLNRTVLAA AYIAGIKKIF RIGGAQAIGA
210 220 230 240 250
LSYGTQTIPR VDVISGPGNL YVTLAKKLVY GQVGIDSLAG PSEVLIIADH
260 270 280 290 300
SADVEQVATD LLAQAEHDPL AASILLTTES NLAKKINLEI ENQLKDHPRS
310 320 330 340 350
AICRKSLKDW GLIVICKDIK SCAALSNSFA PEHLELLIEK PFEFISQIKN
360 370 380 390 400
AGAIFLGEWS PEATGDYLAG PNHTLPTSGT ARFSSALSVE TFMKSTSIIN
410 420 430 440
FNQAALNKTS AAIMELANSE GLHSHSRSIE IRRSKPSSDD
Length:440
Mass (Da):47,721
Last modified:October 1, 2003 - v1
Checksum:iB7150E41CA0679AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAQ00687.1
RefSeqiNP_876034.1, NC_005042.1
WP_011125793.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAQ00687; AAQ00687; Pro_1643
GeneIDi1463025
KEGGipma:Pro_1643
PATRICifig|167539.5.peg.1738

Similar proteinsi

Entry informationi

Entry nameiHISX_PROMA
AccessioniPrimary (citable) accession number: Q7VA26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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