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Q7VA26 (HISX_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:Pro_1643
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135813

Sites

Active site3321Proton acceptor By similarity
Active site3331Proton acceptor By similarity
Metal binding2641Zinc By similarity
Metal binding2671Zinc By similarity
Metal binding3661Zinc By similarity
Metal binding4251Zinc By similarity
Binding site1341NAD By similarity
Binding site1961NAD By similarity
Binding site2191NAD By similarity
Binding site2421Substrate By similarity
Binding site2641Substrate By similarity
Binding site2671Substrate By similarity
Binding site3331Substrate By similarity
Binding site3661Substrate By similarity
Binding site4201Substrate By similarity
Binding site4251Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VA26 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: B7150E41CA0679AF

FASTA44047,721
        10         20         30         40         50         60 
MSERKQILNC IDDPQQALIM LKRISARTSL EVQENAISSV QNILTEVKQL GDEALFRLTE 

        70         80         90        100        110        120 
KFDGFIPKPL EITPEQTLEA WEKTPTPLQE ALQLAKNRIE AFHKYQIPKD FLKEGIHGEL 

       130        140        150        160        170        180 
LGKNWSPVEK AGIYIPGGRA AYPSTVLMNA VPALVAGVNE IIMVSPAGPN GQLNRTVLAA 

       190        200        210        220        230        240 
AYIAGIKKIF RIGGAQAIGA LSYGTQTIPR VDVISGPGNL YVTLAKKLVY GQVGIDSLAG 

       250        260        270        280        290        300 
PSEVLIIADH SADVEQVATD LLAQAEHDPL AASILLTTES NLAKKINLEI ENQLKDHPRS 

       310        320        330        340        350        360 
AICRKSLKDW GLIVICKDIK SCAALSNSFA PEHLELLIEK PFEFISQIKN AGAIFLGEWS 

       370        380        390        400        410        420 
PEATGDYLAG PNHTLPTSGT ARFSSALSVE TFMKSTSIIN FNQAALNKTS AAIMELANSE 

       430        440 
GLHSHSRSIE IRRSKPSSDD 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAQ00687.1.
RefSeqNP_876034.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7VA26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro1643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ00687; AAQ00687; Pro_1643.
GeneID1463025.
KEGGpma:Pro_1643.
PATRIC23030113. VBIProMar8617_1738.

Phylogenomic databases

eggNOGCOG0141.
KOK00013.
OMAYAAKLCG.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-1679-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_PROMA
AccessionPrimary (citable) accession number: Q7VA26
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways