Q7V9Z2 (ALR_PROMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	Pro_1681

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]

Taxonomic identifier

167539 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus › Prochlorococcus marinus › Prochlorococcus marinus subsp. marinus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP-Rule MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Alanine racemase HAMAP-Rule MF_01201		PRO_1000066025
Sites
	Active site	48	1	Proton acceptor; specific for D-alanine By similarity
	Active site	279	1	Proton acceptor; specific for L-alanine By similarity
	Binding site	147	1	Substrate By similarity
	Binding site	327	1	Substrate; via amide nitrogen By similarity
Amino acid modifications
	Modified residue	48	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7V9Z2 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8C7CF47477A917E5	FASTA	386	41,899
	10 20 30 40 50 60 MATTSMPLNK IDPRQRAWVE VSPDAIKANT LAIRSLLDEQ CLLMAVVKAD GYGHGSETVA 70 80 90 100 110 120 EAALAGGATN LGVATLQEAL ELRKAGIVCP ILVLGNLINP EDLDACIHWD LMPTLSSARE 130 140 150 160 170 180 ALLCNQIAES HDKEFCVHIK VDTGMTRLGC DLRLASELIQ LVDNLKNLSL RGIYSHLALA 190 200 210 220 230 240 DVEANGQANS FTSKQKEKFE TLLSSVMPRG KPLYRHLANS AGTLRDKGLH FDMVRVGLAL 250 260 270 280 290 300 YGYSPLKDLR NNFSLQPALA VRAKVTLLRD VPSDTGVSYG HTFITQRPSR LAVVGIGYAD 310 320 330 340 350 360 GISRALSGKM SVLIDGKFYP QVGSITMDQL VIDITESPQI QIGSVVTLLG VDGDSAITPY 370 380 DWSEISGSIP WEILCSFKYR LPRVVI

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017126 Genomic DNA. Translation: AAQ00725.1.
RefSeq	NP_876072.1. NC_005042.1.
3D structure databases
HSSP	HSSP built from PDB template 1XFC based on UniProtKB P0A4X2.
ProteinModelPortal	Q7V9Z2.
ModBase	Search...
Protein-protein interaction databases
STRING	167539.Pro1681.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAQ00725; AAQ00725; Pro_1681.
GeneID	1463063.
KEGG	pma:Pro1681.
PATRIC	23030191. VBIProMar8617_1775.
Phylogenomic databases
eggNOG	COG0787.
KO	K01775.
OMA	YRTERET.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	PMAR167539:GJN2-1719-MONOMER.
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_PROMA

Accession

Primary (citable) accession number: Q7V9Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program