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Protein

Alanine racemase

Gene

alr

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei48Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei147SubstrateUniRule annotation1
Active sitei279Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei327Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-1719-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:Pro_1681
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000660251 – 386Alanine racemaseAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ7V9Z2

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro1681

Structurei

3D structure databases

ProteinModelPortaliQ7V9Z2
SMRiQ7V9Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7V9Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTSMPLNK IDPRQRAWVE VSPDAIKANT LAIRSLLDEQ CLLMAVVKAD
60 70 80 90 100
GYGHGSETVA EAALAGGATN LGVATLQEAL ELRKAGIVCP ILVLGNLINP
110 120 130 140 150
EDLDACIHWD LMPTLSSARE ALLCNQIAES HDKEFCVHIK VDTGMTRLGC
160 170 180 190 200
DLRLASELIQ LVDNLKNLSL RGIYSHLALA DVEANGQANS FTSKQKEKFE
210 220 230 240 250
TLLSSVMPRG KPLYRHLANS AGTLRDKGLH FDMVRVGLAL YGYSPLKDLR
260 270 280 290 300
NNFSLQPALA VRAKVTLLRD VPSDTGVSYG HTFITQRPSR LAVVGIGYAD
310 320 330 340 350
GISRALSGKM SVLIDGKFYP QVGSITMDQL VIDITESPQI QIGSVVTLLG
360 370 380
VDGDSAITPY DWSEISGSIP WEILCSFKYR LPRVVI
Length:386
Mass (Da):41,899
Last modified:October 1, 2003 - v1
Checksum:i8C7CF47477A917E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAQ00725.1
RefSeqiNP_876072.1, NC_005042.1
WP_011125830.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAQ00725; AAQ00725; Pro_1681
GeneIDi1463063
KEGGipma:Pro_1681
PATRICifig|167539.5.peg.1775

Similar proteinsi

Entry informationi

Entry nameiALR_PROMA
AccessioniPrimary (citable) accession number: Q7V9Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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