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Q7V9S8 (PANCY_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

  1. Pantoate--beta-alanine ligase
    EC=6.3.2.1
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
  2. Cytidylate kinase
    Short name=CK
    EC=2.7.4.14
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name=CMP kinase
Gene names
Name:panC/cmk
Ordered Locus Names:Pro_1746
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.

In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_00158
PRO_0000239790

Regions

Nucleotide binding295 – 3039ATP By similarity
Region1 – 282282Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Region283 – 519237Cytidylate kinase HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
Q7V9S8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 268B7AFEF6EA074C

FASTA51958,064
        10         20         30         40         50         60 
MNLTILRTKT ALEDWCRQKH NHEINFVPTM GGLHQGHQEL IKTARSFCKR KHSSQVLVSI 

        70         80         90        100        110        120 
FINPLQFDLE EDFKKYPRTF ENDCKIAYEA GANAIWAPSF ESVFPNGEEA HFKIQVPFSL 

       130        140        150        160        170        180 
NKYLCGASRE GHFDGVATVV VRLLALVRPN RIFLGEKDWQ QLVILRQLIN DLGLPVLIHS 

       190        200        210        220        230        240 
IPTKRDQDGL PCSSRNVNLS KEERKKVVAL PAVLQQAAQA FQENKPINLN NMKTTLEEHD 

       250        260        270        280        290        300 
LKVEYLETVD LKNLNPVNHD ESKLCLLAAA VHCGNTRLID HGFLMKRNPI VAIDGPAGAG 

       310        320        330        340        350        360 
KSTVTKKFAQ KLGLIYLDTG AMYRAVTWLI QENNIDPQNS SELELILNDI NLDICLSNTG 

       370        380        390        400        410        420 
NQQVLINGKD ITTLIRSPTV TSQVSLVAAI GSVREKLTSQ QKELGSKGGL VAEGRDIGTA 

       430        440        450        460        470        480 
VFPDAELKIF LTATAQERAK RRAIDLKKQG FSTPSLSELE KQIKERDRLD SSREIAPLSK 

       490        500        510 
AKDAQELITD GMNIEEVVEL LINIFREKIP QEVWPTNAT 

« Hide

References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAQ00790.1.
RefSeqNP_876137.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7V9S8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro1746.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ00790; AAQ00790; Pro_1746.
GeneID1463128.
KEGGpma:Pro_1746.
PATRIC23030333. VBIProMar8617_1844.

Phylogenomic databases

eggNOGCOG0283.
KOK13799.
OMALGEKDWQ.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-1787-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANCY_PROMA
AccessionPrimary (citable) accession number: Q7V9S8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways