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Q7V9S8

- PANCY_PROMA

UniProt

Q7V9S8 - PANCY_PROMA

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
    ATP + (d)CMP = ADP + (d)CDP.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi295 – 3039ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR167539:GJN2-1787-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinase
    Including the following 2 domains:
    Pantoate--beta-alanine ligase (EC:6.3.2.1)
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
    Cytidylate kinase (EC:2.7.4.14)
    Short name:
    CK
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name:
    CMP kinase
    Gene namesi
    Name:panC/cmk
    Ordered Locus Names:Pro_1746
    OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
    Taxonomic identifieri167539 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001420: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Bifunctional pantoate ligase/cytidylate kinasePRO_0000239790Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167539.Pro1746.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V9S8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 282282Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni283 – 519237Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.Curated
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0283.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V9S8-1 [UniParc]FASTAAdd to Basket

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    MNLTILRTKT ALEDWCRQKH NHEINFVPTM GGLHQGHQEL IKTARSFCKR    50
    KHSSQVLVSI FINPLQFDLE EDFKKYPRTF ENDCKIAYEA GANAIWAPSF 100
    ESVFPNGEEA HFKIQVPFSL NKYLCGASRE GHFDGVATVV VRLLALVRPN 150
    RIFLGEKDWQ QLVILRQLIN DLGLPVLIHS IPTKRDQDGL PCSSRNVNLS 200
    KEERKKVVAL PAVLQQAAQA FQENKPINLN NMKTTLEEHD LKVEYLETVD 250
    LKNLNPVNHD ESKLCLLAAA VHCGNTRLID HGFLMKRNPI VAIDGPAGAG 300
    KSTVTKKFAQ KLGLIYLDTG AMYRAVTWLI QENNIDPQNS SELELILNDI 350
    NLDICLSNTG NQQVLINGKD ITTLIRSPTV TSQVSLVAAI GSVREKLTSQ 400
    QKELGSKGGL VAEGRDIGTA VFPDAELKIF LTATAQERAK RRAIDLKKQG 450
    FSTPSLSELE KQIKERDRLD SSREIAPLSK AKDAQELITD GMNIEEVVEL 500
    LINIFREKIP QEVWPTNAT 519
    Length:519
    Mass (Da):58,064
    Last modified:October 1, 2003 - v1
    Checksum:i268B7AFEF6EA074C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAQ00790.1.
    RefSeqiNP_876137.1. NC_005042.1.
    WP_011125895.1. NC_005042.1.

    Genome annotation databases

    EnsemblBacteriaiAAQ00790; AAQ00790; Pro_1746.
    GeneIDi1463128.
    KEGGipma:Pro_1746.
    PATRICi23030333. VBIProMar8617_1844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAQ00790.1 .
    RefSeqi NP_876137.1. NC_005042.1.
    WP_011125895.1. NC_005042.1.

    3D structure databases

    ProteinModelPortali Q7V9S8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167539.Pro1746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ00790 ; AAQ00790 ; Pro_1746 .
    GeneIDi 1463128.
    KEGGi pma:Pro_1746.
    PATRICi 23030333. VBIProMar8617_1844.

    Phylogenomic databases

    eggNOGi COG0283.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci PMAR167539:GJN2-1787-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SARG / CCMP1375 / SS120.

    Entry informationi

    Entry nameiPANCY_PROMA
    AccessioniPrimary (citable) accession number: Q7V9S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3