Q7V9S8 (PANCY_PROMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

1. Pantoate--beta-alanine ligase
   EC=6.3.2.1
   Alternative name(s):
   Pantoate-activating enzyme
   Pantothenate synthetase
2. Cytidylate kinase
   Short name=CK
   EC=2.7.4.14
   Alternative name(s):
   Cytidine monophosphate kinase
   Short name=CMP kinase

Gene names

Name:	panC/cmk
Ordered Locus Names:	Pro_1746

Organism

Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)

Taxonomic identifier

167539 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_01349
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_01349
Subcellular location	Cytoplasm By similarity HAMAP MF_01349.
Sequence similarities	In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Ligase Transferase
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: EC pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Bifunctional pantoate ligase/cytidylate kinase HAMAP MF_01349		PRO_0000239790
Regions
	Nucleotide binding	295 – 303	9	ATP By similarity
	Region	1 – 282	282	Pantoate--beta-alanine ligase HAMAP MF_01349
	Region	283 – 519	237	Cytidylate kinase HAMAP MF_01349

Sequences

	Sequence		Length	Mass (Da)
	Q7V9S8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 268B7AFEF6EA074C	FASTA	519	58,064
	10 20 30 40 50 60 MNLTILRTKT ALEDWCRQKH NHEINFVPTM GGLHQGHQEL IKTARSFCKR KHSSQVLVSI 70 80 90 100 110 120 FINPLQFDLE EDFKKYPRTF ENDCKIAYEA GANAIWAPSF ESVFPNGEEA HFKIQVPFSL 130 140 150 160 170 180 NKYLCGASRE GHFDGVATVV VRLLALVRPN RIFLGEKDWQ QLVILRQLIN DLGLPVLIHS 190 200 210 220 230 240 IPTKRDQDGL PCSSRNVNLS KEERKKVVAL PAVLQQAAQA FQENKPINLN NMKTTLEEHD 250 260 270 280 290 300 LKVEYLETVD LKNLNPVNHD ESKLCLLAAA VHCGNTRLID HGFLMKRNPI VAIDGPAGAG 310 320 330 340 350 360 KSTVTKKFAQ KLGLIYLDTG AMYRAVTWLI QENNIDPQNS SELELILNDI NLDICLSNTG 370 380 390 400 410 420 NQQVLINGKD ITTLIRSPTV TSQVSLVAAI GSVREKLTSQ QKELGSKGGL VAEGRDIGTA 430 440 450 460 470 480 VFPDAELKIF LTATAQERAK RRAIDLKKQG FSTPSLSELE KQIKERDRLD SSREIAPLSK 490 500 510 AKDAQELITD GMNIEEVVEL LINIFREKIP QEVWPTNAT

References

[1]

"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome." Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. , Wincker P., Wolf Y.I., Hess W.R. Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed: 12917486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017126 Genomic DNA. Translation: AAQ00790.1.
RefSeq	NP_876137.1. NC_005042.1.
3D structure databases
ProteinModelPortal	Q7V9S8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1463128.
GenomeReviews	Gene locus Pro_1746 in contig AE017126_GR.
KEGG	pma:Pro1746.
PATRIC	23030333. VBIProMar8617_1844.
Phylogenomic databases
HOGENOM	HBG428839.
OMA	LGEKDWQ.
ProtClustDB	PRK13477.
Enzyme and pathway databases
BioCyc	PMAR167539:PRO_1746-MONOMER.
Family and domain databases
HAMAP	MF_01349. PanCY. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. IPR003721. Pantoate_ligase. IPR024894. Pantoate_ligase/cytidylate_kin. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K13799.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit. TIGR00018. PanC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANCY_PROMA

Accession

Primary (citable) accession number: Q7V9S8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program