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Q7V9K4

- GCSP_PROMA

UniProt

Q7V9K4 - GCSP_PROMA

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Pro_1829
Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-1873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Pro_1829
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei711 – 7111N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi167539.Pro1829.

Structurei

3D structure databases

ProteinModelPortaliQ7V9K4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V9K4-1 [UniParc]FASTAAdd to Basket

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MRNTKASKFS DRHLGLIEEA QVEILNALGH ADINDFISSV VPEEILDAQP    50
PDELLPKALN EIEALEELRS IAKKNQIKRS LIGLGYYGTY TPAVIQRHVF 100
ENPAWYTSYT PYQAEIAQGR LEALFNFQTL ITELTGLPIA NASLLDEGTA 150
AAEAMSLSFA VNKQTKARKF IVDDQVLPQT LAVLKTRAEP LELDIEVVNL 200
TDLVINETVF GLLIQLPGKS GQLWDPSSLI AQAHEFNALV TVAIDPLAQV 250
LIAPMGQLGV DIAIGSSQRF GVPIGFGGPH AAFFAIKEEY KRLVPGRLVG 300
QSIDSKGHSA LRLALQTREQ HIRRDKATSN ICTAQALLAT IASFYAVYHG 350
PHGLEEIAKN IIYLRSQLEL YLKEFGYTFA PDCRFDTLEI HCLEAPEIHR 400
LSILSGFNLR ILPLGASIEK SKGFAVSFDE LSTTKELYKL CKIFADVKDK 450
NFEPRENTNF NFKESLTSLP LRTTPWLKQQ VFNNYRTETE LMRYIQKLAS 500
RDFSLVNGMI PLGSCTMKLN ATAELLPITW KEFSSIHPFV PSDQAKGYGY 550
LSEQLEGWLC ALTGFDGVSL QPNAGSQGEF AGLLVIRAWH KAINQADRNI 600
CLIPKSAHGT NPASAVMAGF KVVAVECDEY GNIDFEDLVL KVETYSSELG 650
ALMITYPSTH GVFEPNIRQI CDQVHLHGGQ VYLDGANLNA QVGLCRPGAF 700
GADVCHLNLH KTFCIPHGGG GPGIGPIAVA KHLVAFLPSK NFHASDNNAA 750
IGAISASPLG SASILPISWM YIRMMGADGL RQASSLAILS ANYIANKLDP 800
YFQVLFKAPN GKVAHECILD LRSIKRITGI EVDDVAKRLM DYGFHAPTIS 850
WPVAGTLMIE PTESESFEEI NRFCEAMISI RSEIDAIESG ITDLSNNPLR 900
LAPHTMETVT AEIWDRPYTR QQAAFPLKDQ FMNKFWPAVS RIDNAFGDRN 950
LVCSCSTLEE LSET 964
Length:964
Mass (Da):106,218
Last modified:October 1, 2003 - v1
Checksum:iB2452DAF167A1695
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAQ00873.1.
RefSeqiNP_876220.1. NC_005042.1.
WP_011125978.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAQ00873; AAQ00873; Pro_1829.
GeneIDi1463212.
KEGGipma:Pro_1829.
PATRICi23030511. VBIProMar8617_1931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017126 Genomic DNA. Translation: AAQ00873.1 .
RefSeqi NP_876220.1. NC_005042.1.
WP_011125978.1. NC_005042.1.

3D structure databases

ProteinModelPortali Q7V9K4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167539.Pro1829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ00873 ; AAQ00873 ; Pro_1829 .
GeneIDi 1463212.
KEGGi pma:Pro_1829.
PATRICi 23030511. VBIProMar8617_1931.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PMAR167539:GJN2-1873-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SARG / CCMP1375 / SS120.

Entry informationi

Entry nameiGCSP_PROMA
AccessioniPrimary (citable) accession number: Q7V9K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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