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Q7V9K4

- GCSP_PROMA

UniProt

Q7V9K4 - GCSP_PROMA

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR167539:GJN2-1873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Pro_1829
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Glycine dehydrogenase (decarboxylating)PRO_0000166923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi167539.Pro1829.

Structurei

3D structure databases

ProteinModelPortaliQ7V9K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V9K4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNTKASKFS DRHLGLIEEA QVEILNALGH ADINDFISSV VPEEILDAQP
60 70 80 90 100
PDELLPKALN EIEALEELRS IAKKNQIKRS LIGLGYYGTY TPAVIQRHVF
110 120 130 140 150
ENPAWYTSYT PYQAEIAQGR LEALFNFQTL ITELTGLPIA NASLLDEGTA
160 170 180 190 200
AAEAMSLSFA VNKQTKARKF IVDDQVLPQT LAVLKTRAEP LELDIEVVNL
210 220 230 240 250
TDLVINETVF GLLIQLPGKS GQLWDPSSLI AQAHEFNALV TVAIDPLAQV
260 270 280 290 300
LIAPMGQLGV DIAIGSSQRF GVPIGFGGPH AAFFAIKEEY KRLVPGRLVG
310 320 330 340 350
QSIDSKGHSA LRLALQTREQ HIRRDKATSN ICTAQALLAT IASFYAVYHG
360 370 380 390 400
PHGLEEIAKN IIYLRSQLEL YLKEFGYTFA PDCRFDTLEI HCLEAPEIHR
410 420 430 440 450
LSILSGFNLR ILPLGASIEK SKGFAVSFDE LSTTKELYKL CKIFADVKDK
460 470 480 490 500
NFEPRENTNF NFKESLTSLP LRTTPWLKQQ VFNNYRTETE LMRYIQKLAS
510 520 530 540 550
RDFSLVNGMI PLGSCTMKLN ATAELLPITW KEFSSIHPFV PSDQAKGYGY
560 570 580 590 600
LSEQLEGWLC ALTGFDGVSL QPNAGSQGEF AGLLVIRAWH KAINQADRNI
610 620 630 640 650
CLIPKSAHGT NPASAVMAGF KVVAVECDEY GNIDFEDLVL KVETYSSELG
660 670 680 690 700
ALMITYPSTH GVFEPNIRQI CDQVHLHGGQ VYLDGANLNA QVGLCRPGAF
710 720 730 740 750
GADVCHLNLH KTFCIPHGGG GPGIGPIAVA KHLVAFLPSK NFHASDNNAA
760 770 780 790 800
IGAISASPLG SASILPISWM YIRMMGADGL RQASSLAILS ANYIANKLDP
810 820 830 840 850
YFQVLFKAPN GKVAHECILD LRSIKRITGI EVDDVAKRLM DYGFHAPTIS
860 870 880 890 900
WPVAGTLMIE PTESESFEEI NRFCEAMISI RSEIDAIESG ITDLSNNPLR
910 920 930 940 950
LAPHTMETVT AEIWDRPYTR QQAAFPLKDQ FMNKFWPAVS RIDNAFGDRN
960
LVCSCSTLEE LSET
Length:964
Mass (Da):106,218
Last modified:October 1, 2003 - v1
Checksum:iB2452DAF167A1695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA. Translation: AAQ00873.1.
RefSeqiNP_876220.1. NC_005042.1.

Genome annotation databases

EnsemblBacteriaiAAQ00873; AAQ00873; Pro_1829.
GeneIDi1463212.
KEGGipma:Pro_1829.
PATRICi23030511. VBIProMar8617_1931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA. Translation: AAQ00873.1 .
RefSeqi NP_876220.1. NC_005042.1.

3D structure databases

ProteinModelPortali Q7V9K4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167539.Pro1829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ00873 ; AAQ00873 ; Pro_1829 .
GeneIDi 1463212.
KEGGi pma:Pro_1829.
PATRICi 23030511. VBIProMar8617_1931.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PMAR167539:GJN2-1873-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SARG / CCMP1375 / SS120.

Entry informationi

Entry nameiGCSP_PROMA
AccessioniPrimary (citable) accession number: Q7V9K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3