Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7V9K4

- GCSP_PROMA

UniProt

Q7V9K4 - GCSP_PROMA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPMAR167539:GJN2-1873-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Pro_1829
    OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
    Taxonomic identifieri167539 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001420: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 964964Glycine dehydrogenase (decarboxylating)PRO_0000166923Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei711 – 7111N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi167539.Pro1829.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V9K4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V9K4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNTKASKFS DRHLGLIEEA QVEILNALGH ADINDFISSV VPEEILDAQP    50
    PDELLPKALN EIEALEELRS IAKKNQIKRS LIGLGYYGTY TPAVIQRHVF 100
    ENPAWYTSYT PYQAEIAQGR LEALFNFQTL ITELTGLPIA NASLLDEGTA 150
    AAEAMSLSFA VNKQTKARKF IVDDQVLPQT LAVLKTRAEP LELDIEVVNL 200
    TDLVINETVF GLLIQLPGKS GQLWDPSSLI AQAHEFNALV TVAIDPLAQV 250
    LIAPMGQLGV DIAIGSSQRF GVPIGFGGPH AAFFAIKEEY KRLVPGRLVG 300
    QSIDSKGHSA LRLALQTREQ HIRRDKATSN ICTAQALLAT IASFYAVYHG 350
    PHGLEEIAKN IIYLRSQLEL YLKEFGYTFA PDCRFDTLEI HCLEAPEIHR 400
    LSILSGFNLR ILPLGASIEK SKGFAVSFDE LSTTKELYKL CKIFADVKDK 450
    NFEPRENTNF NFKESLTSLP LRTTPWLKQQ VFNNYRTETE LMRYIQKLAS 500
    RDFSLVNGMI PLGSCTMKLN ATAELLPITW KEFSSIHPFV PSDQAKGYGY 550
    LSEQLEGWLC ALTGFDGVSL QPNAGSQGEF AGLLVIRAWH KAINQADRNI 600
    CLIPKSAHGT NPASAVMAGF KVVAVECDEY GNIDFEDLVL KVETYSSELG 650
    ALMITYPSTH GVFEPNIRQI CDQVHLHGGQ VYLDGANLNA QVGLCRPGAF 700
    GADVCHLNLH KTFCIPHGGG GPGIGPIAVA KHLVAFLPSK NFHASDNNAA 750
    IGAISASPLG SASILPISWM YIRMMGADGL RQASSLAILS ANYIANKLDP 800
    YFQVLFKAPN GKVAHECILD LRSIKRITGI EVDDVAKRLM DYGFHAPTIS 850
    WPVAGTLMIE PTESESFEEI NRFCEAMISI RSEIDAIESG ITDLSNNPLR 900
    LAPHTMETVT AEIWDRPYTR QQAAFPLKDQ FMNKFWPAVS RIDNAFGDRN 950
    LVCSCSTLEE LSET 964
    Length:964
    Mass (Da):106,218
    Last modified:October 1, 2003 - v1
    Checksum:iB2452DAF167A1695
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAQ00873.1.
    RefSeqiNP_876220.1. NC_005042.1.
    WP_011125978.1. NC_005042.1.

    Genome annotation databases

    EnsemblBacteriaiAAQ00873; AAQ00873; Pro_1829.
    GeneIDi1463212.
    KEGGipma:Pro_1829.
    PATRICi23030511. VBIProMar8617_1931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017126 Genomic DNA. Translation: AAQ00873.1 .
    RefSeqi NP_876220.1. NC_005042.1.
    WP_011125978.1. NC_005042.1.

    3D structure databases

    ProteinModelPortali Q7V9K4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167539.Pro1829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ00873 ; AAQ00873 ; Pro_1829 .
    GeneIDi 1463212.
    KEGGi pma:Pro_1829.
    PATRICi 23030511. VBIProMar8617_1931.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PMAR167539:GJN2-1873-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SARG / CCMP1375 / SS120.

    Entry informationi

    Entry nameiGCSP_PROMA
    AccessioniPrimary (citable) accession number: Q7V9K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3