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Q7V9K4 (GCSP_PROMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Pro_1829
OrganismProchlorococcus marinus (strain SARG / CCMP1375 / SS120) [Reference proteome] [HAMAP]
Taxonomic identifier167539 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length964 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 964964Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166923

Amino acid modifications

Modified residue7111N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7V9K4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: B2452DAF167A1695

FASTA964106,218
        10         20         30         40         50         60 
MRNTKASKFS DRHLGLIEEA QVEILNALGH ADINDFISSV VPEEILDAQP PDELLPKALN 

        70         80         90        100        110        120 
EIEALEELRS IAKKNQIKRS LIGLGYYGTY TPAVIQRHVF ENPAWYTSYT PYQAEIAQGR 

       130        140        150        160        170        180 
LEALFNFQTL ITELTGLPIA NASLLDEGTA AAEAMSLSFA VNKQTKARKF IVDDQVLPQT 

       190        200        210        220        230        240 
LAVLKTRAEP LELDIEVVNL TDLVINETVF GLLIQLPGKS GQLWDPSSLI AQAHEFNALV 

       250        260        270        280        290        300 
TVAIDPLAQV LIAPMGQLGV DIAIGSSQRF GVPIGFGGPH AAFFAIKEEY KRLVPGRLVG 

       310        320        330        340        350        360 
QSIDSKGHSA LRLALQTREQ HIRRDKATSN ICTAQALLAT IASFYAVYHG PHGLEEIAKN 

       370        380        390        400        410        420 
IIYLRSQLEL YLKEFGYTFA PDCRFDTLEI HCLEAPEIHR LSILSGFNLR ILPLGASIEK 

       430        440        450        460        470        480 
SKGFAVSFDE LSTTKELYKL CKIFADVKDK NFEPRENTNF NFKESLTSLP LRTTPWLKQQ 

       490        500        510        520        530        540 
VFNNYRTETE LMRYIQKLAS RDFSLVNGMI PLGSCTMKLN ATAELLPITW KEFSSIHPFV 

       550        560        570        580        590        600 
PSDQAKGYGY LSEQLEGWLC ALTGFDGVSL QPNAGSQGEF AGLLVIRAWH KAINQADRNI 

       610        620        630        640        650        660 
CLIPKSAHGT NPASAVMAGF KVVAVECDEY GNIDFEDLVL KVETYSSELG ALMITYPSTH 

       670        680        690        700        710        720 
GVFEPNIRQI CDQVHLHGGQ VYLDGANLNA QVGLCRPGAF GADVCHLNLH KTFCIPHGGG 

       730        740        750        760        770        780 
GPGIGPIAVA KHLVAFLPSK NFHASDNNAA IGAISASPLG SASILPISWM YIRMMGADGL 

       790        800        810        820        830        840 
RQASSLAILS ANYIANKLDP YFQVLFKAPN GKVAHECILD LRSIKRITGI EVDDVAKRLM 

       850        860        870        880        890        900 
DYGFHAPTIS WPVAGTLMIE PTESESFEEI NRFCEAMISI RSEIDAIESG ITDLSNNPLR 

       910        920        930        940        950        960 
LAPHTMETVT AEIWDRPYTR QQAAFPLKDQ FMNKFWPAVS RIDNAFGDRN LVCSCSTLEE 


LSET 

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References

[1]"Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome."
Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M., Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S., Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J., Tandeau de Marsac N., Weissenbach J. expand/collapse author list , Wincker P., Wolf Y.I., Hess W.R.
Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SARG / CCMP1375 / SS120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017126 Genomic DNA. Translation: AAQ00873.1.
RefSeqNP_876220.1. NC_005042.1.

3D structure databases

ProteinModelPortalQ7V9K4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167539.Pro1829.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ00873; AAQ00873; Pro_1829.
GeneID1463212.
KEGGpma:Pro_1829.
PATRIC23030511. VBIProMar8617_1931.

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPMAR167539:GJN2-1873-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PROMA
AccessionPrimary (citable) accession number: Q7V9K4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families