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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciPMAR167539:G1G0G-1923-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Pro_1878
OrganismiProchlorococcus marinus (strain SARG / CCMP1375 / SS120)
Taxonomic identifieri167539 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001420 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalUniRule annotationAdd BLAST21
Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Transmembranei181 – 201HelicalUniRule annotationAdd BLAST21
Transmembranei217 – 237HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21
Transmembranei270 – 290HelicalUniRule annotationAdd BLAST21
Transmembranei298 – 318HelicalUniRule annotationAdd BLAST21
Transmembranei349 – 369HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088681 – 370Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST370

Interactioni

Protein-protein interaction databases

STRINGi167539.Pro1878

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7V9F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWKKYINRF KSRDLSENGL PTSILLIIGI IVVSIIVDLF IQKSLLLVPL
60 70 80 90 100
ISSIIISAII TKWGIIKLKK INCRQVVRKE GPSGHFQKSG TPSMGGIFIV
110 120 130 140 150
PISLILTNLF ALSNNTFSKQ LVALSFLSLA YMLIGLIDDW QSITLKRNKG
160 170 180 190 200
LSVKSKVILQ TIVGIIFLVL IYSQDLNNTD ILIFGNNTIN LGLLFWPIAL
210 220 230 240 250
FILLAESNAT NLTDGLDGLA SGCGAIVFTG LAIELIIRGN NENYAIASFC
260 270 280 290 300
ITMAGAWLGF LIFNRKPAKV FMGDTGSLAM GASLAGVALL TNTLWSLLIM
310 320 330 340 350
GVIFLAESVS VIIQVGVFKT TKKIIGKGYR VFNMAPLHHH FELEGTKETI
360 370
IVQNFWLITI CFVCMAIMLR
Length:370
Mass (Da):40,614
Last modified:October 1, 2003 - v1
Checksum:iF61F0604D238A101
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017126 Genomic DNA Translation: AAQ00922.1
RefSeqiNP_876269.1, NC_005042.1
WP_011126027.1, NC_005042.1

Genome annotation databases

EnsemblBacteriaiAAQ00922; AAQ00922; Pro_1878
GeneIDi1463261
KEGGipma:Pro_1878
PATRICifig|167539.5.peg.1981

Similar proteinsi

Entry informationi

Entry nameiMRAY_PROMA
AccessioniPrimary (citable) accession number: Q7V9F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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