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Q7V8Z1

- UPPP_PROMM

UniProt

Q7V8Z1 - UPPP_PROMM

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:PMT_0180
    OrganismiProchlorococcus marinus (strain MIT 9313)
    Taxonomic identifieri74547 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001423: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Undecaprenyl-diphosphatasePRO_0000151179Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi74547.PMT0180.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3223HelicalUniRule annotationAdd
    BLAST
    Transmembranei63 – 8321HelicalUniRule annotationAdd
    BLAST
    Transmembranei112 – 13221HelicalUniRule annotationAdd
    BLAST
    Transmembranei143 – 16321HelicalUniRule annotationAdd
    BLAST
    Transmembranei178 – 19821HelicalUniRule annotationAdd
    BLAST
    Transmembranei213 – 23321HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei276 – 29621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V8Z1-1 [UniParc]FASTAAdd to Basket

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    MGAIASMGPL FSLMILLAAT SELLAACWRN LVLGVVQGLT EFLPISSTAH    50
    LKVVPMLVGW GDPGVSATAV IQLGSILAVI AYFKRDLAEV LKGIALAFKH 100
    GQWREPNARL GLAIAIGTMP ILLAGMAIKL FWPGYEASSI RSLPSIAVVS 150
    IVMALLLALA ESFGPRLKQM HLVKGRDGFV VGLAQALALI PGVSRSGSTL 200
    TASLFDGWQR QDAARFCFLL GIPAITLAGL VELKDAFAEL SLGGVLPLLV 250
    GIVSAAFVSW LAIDWLLKYL QSHSTWIFVV YRLLFGVLVL AWWLSGRSN 299
    Length:299
    Mass (Da):31,933
    Last modified:October 1, 2003 - v1
    Checksum:iD7B1C9B959B28414
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE20355.1.
    RefSeqiNP_894013.1. NC_005071.1.

    Genome annotation databases

    EnsemblBacteriaiCAE20355; CAE20355; PMT_0180.
    GeneIDi1728852.
    KEGGipmt:PMT0180.
    PATRICi23008053. VBIProMar135351_0194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE20355.1 .
    RefSeqi NP_894013.1. NC_005071.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74547.PMT0180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE20355 ; CAE20355 ; PMT_0180 .
    GeneIDi 1728852.
    KEGGi pmt:PMT0180.
    PATRICi 23008053. VBIProMar135351_0194.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9313.

    Entry informationi

    Entry nameiUPPP_PROMM
    AccessioniPrimary (citable) accession number: Q7V8Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3