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Q7V8Z1 (UPPP_PROMM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:PMT_0180
OrganismProchlorococcus marinus (strain MIT 9313) [Complete proteome] [HAMAP]
Taxonomic identifier74547 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151179

Regions

Transmembrane10 – 3223Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane276 – 29621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7V8Z1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D7B1C9B959B28414

FASTA29931,933
        10         20         30         40         50         60 
MGAIASMGPL FSLMILLAAT SELLAACWRN LVLGVVQGLT EFLPISSTAH LKVVPMLVGW 

        70         80         90        100        110        120 
GDPGVSATAV IQLGSILAVI AYFKRDLAEV LKGIALAFKH GQWREPNARL GLAIAIGTMP 

       130        140        150        160        170        180 
ILLAGMAIKL FWPGYEASSI RSLPSIAVVS IVMALLLALA ESFGPRLKQM HLVKGRDGFV 

       190        200        210        220        230        240 
VGLAQALALI PGVSRSGSTL TASLFDGWQR QDAARFCFLL GIPAITLAGL VELKDAFAEL 

       250        260        270        280        290 
SLGGVLPLLV GIVSAAFVSW LAIDWLLKYL QSHSTWIFVV YRLLFGVLVL AWWLSGRSN 

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9313.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX548175 Genomic DNA. Translation: CAE20355.1.
RefSeqNP_894013.1. NC_005071.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING74547.PMT0180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE20355; CAE20355; PMT_0180.
GeneID1728852.
KEGGpmt:PMT0180.
PATRIC23008053. VBIProMar135351_0194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_PROMM
AccessionPrimary (citable) accession number: Q7V8Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families