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Q7V8X5

- MTND_PROMM

UniProt

Q7V8X5 - MTND_PROMM

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Protein
Acireductone dioxygenase
Gene
mtnD, PMT_0197
Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway By similarity.UniRule annotation

Catalytic activityi

1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO.UniRule annotation
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate.

Cofactori

Binds 1 iron ion per monomer By similarity.UniRule annotation
Binds 1 nickel ion per monomer By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei101 – 1011May play a role in metal incorporation in vivo By similarity
Metal bindingi102 – 1021Iron; alternate By similarity
Metal bindingi102 – 1021Nickel; alternate By similarity
Metal bindingi104 – 1041Iron; alternate By similarity
Metal bindingi104 – 1041Nickel; alternate By similarity
Sitei107 – 1071May play a role in transmitting local conformational changes By similarity
Metal bindingi108 – 1081Iron; alternate By similarity
Metal bindingi108 – 1081Nickel; alternate By similarity
Sitei110 – 1101Important to generate the dianion By similarity
Metal bindingi146 – 1461Iron; alternate By similarity
Metal bindingi146 – 1461Nickel; alternate By similarity

GO - Molecular functioni

  1. acireductone dioxygenase (Ni2+-requiring) activity Source: UniProtKB-HAMAP
  2. acireductone dioxygenase [iron(II)-requiring] activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. nickel cation binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from S-adenosylmethionine Source: UniProtKB-HAMAP
  2. L-methionine salvage from methylthioadenosine Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Iron, Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00904; UER00878.

Names & Taxonomyi

Protein namesi
Recommended name:
Acireductone dioxygenase
Alternative name(s):
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Short name:
DHK-MTPene dioxygenase
Acireductone dioxygenase (Fe(2+)-requiring) (EC:1.13.11.54)
Short name:
ARD'
Short name:
Fe-ARD
Acireductone dioxygenase (Ni(2+)-requiring) (EC:1.13.11.53)
Short name:
ARD
Short name:
Ni-ARD
Gene namesi
Name:mtnD
Ordered Locus Names:PMT_0197
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Acireductone dioxygenaseUniRule annotation
PRO_0000359216Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi74547.PMT0197.

Structurei

3D structure databases

ProteinModelPortaliQ7V8X5.
SMRiQ7V8X5. Positions 2-185.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1791.
KOiK08967.
OMAiVLCEKND.
OrthoDBiEOG6ZPT06.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01682. Salvage_MtnD.
InterProiIPR023956. Acireductn_d0ase.
IPR004313. Acireductn_dOase_family.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR23418. PTHR23418. 1 hit.
PfamiPF03079. ARD. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V8X5-1 [UniParc]FASTAAdd to Basket

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MSRLSIHPEG STNATSPAEP LLESDDPAVI KVELAKRGIA FQRWPAKVKL    50
DQNSSESDIL AAYAVEIARV QADGRYPTVD AIRITPDHPD REALRQKFLD 100
EHTHAEDEVR FFVEGCGLFC LHIGAEVLQV LCEQNDCINV PAGTRHWFDM 150
GSKPQFCAVR FFDNPEGWIA NFTGDAIAER FAKLP 185
Length:185
Mass (Da):20,649
Last modified:October 1, 2003 - v1
Checksum:i7F642F7459F8E8C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20372.1.
RefSeqiNP_894030.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE20372; CAE20372; PMT_0197.
GeneIDi1729659.
KEGGipmt:PMT0197.
PATRICi23008113. VBIProMar135351_0217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20372.1 .
RefSeqi NP_894030.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V8X5.
SMRi Q7V8X5. Positions 2-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT0197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE20372 ; CAE20372 ; PMT_0197 .
GeneIDi 1729659.
KEGGi pmt:PMT0197.
PATRICi 23008113. VBIProMar135351_0217.

Phylogenomic databases

eggNOGi COG1791.
KOi K08967.
OMAi VLCEKND.
OrthoDBi EOG6ZPT06.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00878 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_01682. Salvage_MtnD.
InterProi IPR023956. Acireductn_d0ase.
IPR004313. Acireductn_dOase_family.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR23418. PTHR23418. 1 hit.
Pfami PF03079. ARD. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiMTND_PROMM
AccessioniPrimary (citable) accession number: Q7V8X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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