ID   PPNK1_PROMM             Reviewed;         302 AA.
AC   Q7V8H9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Probable inorganic polyphosphate/ATP-NAD kinase 1;
DE            Short=Poly(P)/ATP NAD kinase 1;
DE            EC=2.7.1.23;
GN   Name=ppnK1; OrderedLocusNames=PMT_0368;
OS   Prochlorococcus marinus (strain MIT 9313).
OC   Bacteria; Cyanobacteria; Prochlorophytes; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=74547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22825698; PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P.,
RA   Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R.,
RA   Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M.,
RA   Shaw S.L., Steglich C., Sullivan M.B., Ting C.S., Tolonen A.,
RA   Webb E.A., Zinser E.R., Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic
RT   niche differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Catalyzes the phosphorylation of NAD to NADP. Utilizes
CC       ATP and other nucleoside triphosphates as well as inorganic
CC       polyphosphate as a source of phosphorus (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + NAD(+) = ADP + NADP(+).
CC   -!- COFACTOR: Divalent metal ions (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD kinase family.
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DR   EMBL; BX548175; CAE20543.1; -; Genomic_DNA.
DR   RefSeq; NP_894201.1; -.
DR   GeneID; 1729235; -.
DR   GenomeReviews; BX548175_GR; PMT_0368.
DR   KEGG; pmt:PMT0368; -.
DR   NMPDR; fig|74547.1.peg.368; -.
DR   HOGENOM; Q7V8H9; -.
DR   OMA; Q7V8H9; NDGKELA.
DR   BioCyc; PMAR74547:PMT0368-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:HAMAP.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:HAMAP.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   HAMAP; MF_00361; -; 1.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_all-b.
DR   InterPro; IPR002504; ATP_NADK.
DR   Gene3D; G3DSA:2.60.200.30; ATP-NAD_kinase_PpnK-typ; 1.
DR   PANTHER; PTHR20275; ATP_NADK; 1.
DR   Pfam; PF01513; NAD_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; NAD; NADP;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    302       Probable inorganic polyphosphate/ATP-NAD
FT                                kinase 1.
FT                                /FTId=PRO_0000229670.
SQ   SEQUENCE   302 AA;  32556 MW;  7069AB02F856B280 CRC64;
     MPCVGLIVND GKELAVETAL TLQSRLEQAG IEVVRASSSG GMVGFANPDQ HLRLLGYNAC
     VPEGFDASMA LAIVLGGDGT VLSAARQTAP VQVPILTINT GHLGFLAEAY LADLDRVIEQ
     VLNKQWTIEE RCTLVVSVLR GDQCRWEALS LNEMALHREP LTSMCHFEVA IGRHAPVDIS
     ADGVILSTPT GSTAYALSAG GPVITPECPV LQLAPIAPHS LASRALVFSD QEPVTVFPAT
     ADRLMMVVDG SAGCYVWPED RVLIRRSDHP VRFVRLADHE FFQVLRNKLG WGLPHVAKPD
     RP
//