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Q7V8H9

- NADK1_PROMM

UniProt

Q7V8H9 - NADK1_PROMM

Protein

NAD kinase 1

Gene

nadK1

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei78 – 781Proton acceptorUniRule annotation
    Binding sitei182 – 1821NADUniRule annotation
    Binding sitei217 – 2171NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 792NADUniRule annotation
    Nucleotide bindingi152 – 1532NADUniRule annotation
    Nucleotide bindingi193 – 1986NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 1UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 1UniRule annotation
    Gene namesi
    Name:nadK1UniRule annotation
    Ordered Locus Names:PMT_0368
    OrganismiProchlorococcus marinus (strain MIT 9313)
    Taxonomic identifieri74547 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001423: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302NAD kinase 1PRO_0000229670Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi74547.PMT0368.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V8H9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiHPSIPGW.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V8H9-1 [UniParc]FASTAAdd to Basket

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    MPCVGLIVND GKELAVETAL TLQSRLEQAG IEVVRASSSG GMVGFANPDQ    50
    HLRLLGYNAC VPEGFDASMA LAIVLGGDGT VLSAARQTAP VQVPILTINT 100
    GHLGFLAEAY LADLDRVIEQ VLNKQWTIEE RCTLVVSVLR GDQCRWEALS 150
    LNEMALHREP LTSMCHFEVA IGRHAPVDIS ADGVILSTPT GSTAYALSAG 200
    GPVITPECPV LQLAPIAPHS LASRALVFSD QEPVTVFPAT ADRLMMVVDG 250
    SAGCYVWPED RVLIRRSDHP VRFVRLADHE FFQVLRNKLG WGLPHVAKPD 300
    RP 302
    Length:302
    Mass (Da):32,556
    Last modified:October 1, 2003 - v1
    Checksum:i7069AB02F856B280
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE20543.1.
    RefSeqiNP_894201.1. NC_005071.1.

    Genome annotation databases

    EnsemblBacteriaiCAE20543; CAE20543; PMT_0368.
    GeneIDi1729235.
    KEGGipmt:PMT0368.
    PATRICi23008559. VBIProMar135351_0438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE20543.1 .
    RefSeqi NP_894201.1. NC_005071.1.

    3D structure databases

    ProteinModelPortali Q7V8H9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74547.PMT0368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE20543 ; CAE20543 ; PMT_0368 .
    GeneIDi 1729235.
    KEGGi pmt:PMT0368.
    PATRICi 23008559. VBIProMar135351_0438.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi HPSIPGW.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9313.

    Entry informationi

    Entry nameiNADK1_PROMM
    AccessioniPrimary (citable) accession number: Q7V8H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3