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Q7V8G6

- DEF1_PROMM

UniProt

Q7V8G6 - DEF1_PROMM

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Protein

Peptide deformylase 1

Gene

def1

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011IronUniRule annotation
Metal bindingi143 – 1431IronUniRule annotation
Active sitei144 – 1441UniRule annotation
Metal bindingi147 – 1471IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:PMT_0384
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Peptide deformylase 1PRO_0000082816Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT0384.

Structurei

3D structure databases

ProteinModelPortaliQ7V8G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiRVCQVGD.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V8G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVKEILRMG NPQLRKVSNV VDDASDELII SLIKDLQDTV KAHQGAGLAA
60 70 80 90 100
PQIGVPLRVV LFGGGGPNPR YPEAPSIPQT LLINPVLTPI GSDLEDGWEG
110 120 130 140 150
CLSVPGLRGK VSRWSRIHYR ALNEDGFEVE HCLEGFPARV IQHECDHLDG
160 170 180 190
VLFPDRLVDS ASFGFTGELE TAGIIEKLSS AEQKASQQSR AD
Length:192
Mass (Da):20,788
Last modified:October 1, 2003 - v1
Checksum:iB4E6FE0084A6FC95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20559.1.
RefSeqiNP_894217.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE20559; CAE20559; PMT_0384.
GeneIDi1728773.
KEGGipmt:PMT0384.
PATRICi23008609. VBIProMar135351_0462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20559.1 .
RefSeqi NP_894217.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V8G6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT0384.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE20559 ; CAE20559 ; PMT_0384 .
GeneIDi 1728773.
KEGGi pmt:PMT0384.
PATRICi 23008609. VBIProMar135351_0462.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi RVCQVGD.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiDEF1_PROMM
AccessioniPrimary (citable) accession number: Q7V8G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3