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Q7V8G6

- DEF1_PROMM

UniProt

Q7V8G6 - DEF1_PROMM

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Protein

Peptide deformylase 1

Gene
def1, PMT_0384
Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron By similarity
Metal bindingi143 – 1431Iron By similarity
Active sitei144 – 1441 By similarity
Metal bindingi147 – 1471Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1 (EC:3.5.1.88)
Short name:
PDF 1
Alternative name(s):
Polypeptide deformylase 1
Gene namesi
Name:def1
Ordered Locus Names:PMT_0384
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Peptide deformylase 1UniRule annotationPRO_0000082816Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT0384.

Structurei

3D structure databases

ProteinModelPortaliQ7V8G6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiRVCQVGD.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V8G6-1 [UniParc]FASTAAdd to Basket

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MAVKEILRMG NPQLRKVSNV VDDASDELII SLIKDLQDTV KAHQGAGLAA    50
PQIGVPLRVV LFGGGGPNPR YPEAPSIPQT LLINPVLTPI GSDLEDGWEG 100
CLSVPGLRGK VSRWSRIHYR ALNEDGFEVE HCLEGFPARV IQHECDHLDG 150
VLFPDRLVDS ASFGFTGELE TAGIIEKLSS AEQKASQQSR AD 192
Length:192
Mass (Da):20,788
Last modified:October 1, 2003 - v1
Checksum:iB4E6FE0084A6FC95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20559.1.
RefSeqiNP_894217.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE20559; CAE20559; PMT_0384.
GeneIDi1728773.
KEGGipmt:PMT0384.
PATRICi23008609. VBIProMar135351_0462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20559.1 .
RefSeqi NP_894217.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V8G6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT0384.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE20559 ; CAE20559 ; PMT_0384 .
GeneIDi 1728773.
KEGGi pmt:PMT0384.
PATRICi 23008609. VBIProMar135351_0462.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi RVCQVGD.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiDEF1_PROMM
AccessioniPrimary (citable) accession number: Q7V8G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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