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Q7V896 (Q7V896_PROMM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP MF_00219
Short name=DHOase HAMAP MF_00219
EC=3.5.2.3 HAMAP MF_00219
Gene names
Name:pyrC HAMAP MF_00219 EMBL CAE20643.1
Ordered Locus Names:PMT_0468
OrganismProchlorococcus marinus (strain MIT 9313) [Complete proteome] [HAMAP]
Taxonomic identifier74547 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00219 RuleBase RU003440 SAAS SAAS004721

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00219 RuleBase RU003440 SAAS SAAS004721

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00219 RuleBase RU003440 SAAS SAAS004721

Subunit structure

Homodimer By similarity. HAMAP MF_00219 SAAS SAAS004721

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. HAMAP MF_00219 RuleBase RU003440

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding171Zinc 1 By similarity HAMAP MF_00219
Metal binding191Zinc 1 By similarity HAMAP MF_00219
Metal binding1031Zinc 1; via carbamate group By similarity HAMAP MF_00219
Metal binding1031Zinc 2; via carbamate group By similarity HAMAP MF_00219
Metal binding1401Zinc 2 By similarity HAMAP MF_00219
Metal binding1781Zinc 2 By similarity HAMAP MF_00219
Metal binding2511Zinc 1 By similarity HAMAP MF_00219

Amino acid modifications

Modified residue1031N6-carboxylysine By similarity HAMAP MF_00219

Sequences

Sequence LengthMass (Da)Tools
Q7V896 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D47098039C46AA0F

FASTA35439,151
        10         20         30         40         50         60 
MDSLPDQLIL RQPDDWHVHL RDGAMLHAVL GSTARVFRRA IVMPNLRPPI TSVEAAKTYR 

        70         80         90        100        110        120 
DQILAALPDG VPFTPLMTAY LNESLAPDVL EQGHQQHVFI AAKLYPAHAT TNSEQGVSDL 

       130        140        150        160        170        180 
RAINSLLETM EKIGMPLLVH GEVSDVDIDI FDREAFFIEH HLAPLIGRYP NLRVVMEHIT 

       190        200        210        220        230        240 
TQEAVQFVET GGPNLAATIT PHHLHINRNA MFLGGFRSDF YCLPVAKRER HRLSLRRAAT 

       250        260        270        280        290        300 
SGKPCFFLGT DSAPHPRSAK ESACSCGGIF NAHYAMESYA EVFEQEGALD RLEAFSSEYG 

       310        320        330        340        350 
PAFYGLPLNN TSIKLIRRAH VVPATFSGQT NADSSEHLVP FHAGELLGWS VSVD

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548175 Genomic DNA. Translation: CAE20643.1.
RefSeqNP_894301.1. NC_005071.1.

3D structure databases

HSSPHSSP built from PDB template 1J79 based on UniProtKB P05020.
ProteinModelPortalQ7V896.
SMRQ7V896. Positions 7-352.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7V896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1729403.
GenomeReviewsGene locus PMT_0468 in contig BX548175_GR.
KEGGpmt:PMT0468.
NMPDRfig|74547.1.peg.468.
PATRIC23008809. VBIProMar135351_0561.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBQ7V896.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycPMAR74547:PMT0468-MONOMER.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7V896_PROMM
AccessionPrimary (citable) accession number: Q7V896
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info