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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei349Proton donorUniRule annotation1
Active sitei378UniRule annotation1
Active sitei480UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:PMT_0714
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001423 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807051 – 551Glucose-6-phosphate isomeraseAdd BLAST551

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT0714.

Structurei

3D structure databases

ProteinModelPortaliQ7V7M6.
SMRiQ7V7M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
KOiK01810.
OrthoDBiPOG091H04C3.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 2 hits.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V7M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHFDRGSF RAVSDVHQLM SFPDFSASDA HVQWQRFNNL LWHHNDLGIW
60 70 80 90 100
LDISRMHINA EDFERLGPRF DQAFKAMQAL EQGAIANTDE QRMVGHYWLR
110 120 130 140 150
QPQLAPDQEV CDHIAKEIDL IETFGSNVIN GLIKAPNGKK FTDVLWIGIG
160 170 180 190 200
GSGLGPLLMI RALQNAEQGL RFHFFDNVDP DGMSRVLGNL GDALSTTLVV
210 220 230 240 250
TVSKSGATPE PHLGMEQARQ RLEAMGGHWA GQAVAVTMLN SQLDQLAQKE
260 270 280 290 300
SWLKRFDMFD WVGGRTSITS AVGLLPAALI GCDIRAFLAG AAQMDEATRV
310 320 330 340 350
SDLHSNPASL MAAAWFVAGD GLGRRDMVVL PYRDRLEVFS RYLQQLVMES
360 370 380 390 400
LGKRLDRDGN VVHQGLAVYG NKGSTDQHAY VQQLRDGVDN FFATFIEVLE
410 420 430 440 450
DVENIPAINN EHPGDFLDGF LQGTRAALSQ GGRQSLTISM RRFDPRRLGA
460 470 480 490 500
LVALFERAVG LYGELVNINA YHQPGVESGK KAAAAILNLQ SRVEDLLADG
510 520 530 540 550
VERSAGEIHQ VIGDGSEEAI FWIMRHLTAN KRGYVAEGDW GIPTSLRFSK

G
Length:551
Mass (Da):60,929
Last modified:March 29, 2005 - v2
Checksum:iB569FD6DC1F98AD0
GO

Sequence cautioni

The sequence CAE20889 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE20889.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiCAE20889; CAE20889; PMT_0714.
KEGGipmt:PMT_0714.

Similar proteinsi

Entry informationi

Entry nameiG6PI_PROMM
AccessioniPrimary (citable) accession number: Q7V7M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: August 30, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families