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Q7V7M5

- DAPF_PROMM

UniProt

Q7V7M5 - DAPF_PROMM

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Protein

Diaminopimelate epimerase

Gene
dapF, PMT_0716
Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Substrate By similarity
Binding sitei53 – 531Substrate By similarity
Binding sitei72 – 721Substrate By similarity
Active sitei81 – 811Proton donor/acceptor By similarity
Binding sitei169 – 1691Substrate By similarity
Sitei171 – 1711Important for catalytic activity By similarity
Binding sitei202 – 2021Substrate By similarity
Sitei220 – 2201Important for catalytic activity By similarity
Active sitei229 – 2291Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:PMT_0716
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Diaminopimelate epimeraseUniRule annotationPRO_1000077701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 229UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT0716.

Structurei

3D structure databases

ProteinModelPortaliQ7V7M5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 132Substrate binding By similarity
Regioni81 – 833Substrate binding By similarity
Regioni220 – 2212Substrate binding By similarity
Regioni230 – 2312Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
KOiK01778.
OMAiLIVEPPY.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V7M5-1 [UniParc]FASTAAdd to Basket

« Hide

MLVMLQFSKY QGLGNDFLLI DGREDQLTQQ VINPDPAWVR KICDRHFGIG    50
ADGLILALPP RADGDLRMQI FNADGSLAEM CGNGIRCLTR FLADIEGDLC 100
VQRWNIETLA GIICPVLQED GQICVDMGTP FLDPESIPTT LTIGSAGLPQ 150
GECHLGSTSL HVAAVGMGNP HLIVPVEDLE NIPFENWGQR LEKHHAFPAK 200
TNVHFLKIHS PNQLEIRVWE RGSGPTLACG TGACASLVAT CLLGLSDDHA 250
EVLLPGGVLQ ISWPGRRGSV FMTGPAEPIF DGVLTPLLSP SHAEVLPQDD 300
QII 303
Length:303
Mass (Da):32,747
Last modified:October 1, 2003 - v1
Checksum:i55D2D70E12958C9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20891.1.
RefSeqiNP_894548.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE20891; CAE20891; PMT_0716.
GeneIDi1728549.
KEGGipmt:PMT0716.
PATRICi23009409. VBIProMar135351_0859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE20891.1 .
RefSeqi NP_894548.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V7M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT0716.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE20891 ; CAE20891 ; PMT_0716 .
GeneIDi 1728549.
KEGGi pmt:PMT0716.
PATRICi 23009409. VBIProMar135351_0859.

Phylogenomic databases

eggNOGi COG0253.
KOi K01778.
OMAi LIVEPPY.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiDAPF_PROMM
AccessioniPrimary (citable) accession number: Q7V7M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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