Q7V6M9 (Q7V6M9_PROMM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL CAE21299.1
Ordered Locus Names:	PMT_1124

Organism

Prochlorococcus marinus (strain MIT 9313) [Complete proteome] [HAMAP]

Taxonomic identifier

74547 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	875 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7V6M9 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 6165598CB41C784A	FASTA	875	96,500
	10 20 30 40 50 60 MADPLGPSDG GPGESDDRII QTDLRIEMSR SYLEYAMSVI VGRALPDARD GLKPVHRRIL 70 80 90 100 110 120 YAMYELGLTS DRPYRKCARV VGEVLGKYHP HGDTAVYDAL VRMAQDFSMQ MPLIDGHGNF 130 140 150 160 170 180 GSVDNDPPAA MRYTESRLQS LTTDSLLEDI EAETVDYADN FDGSQQEPMV LPARIPQLLL 190 200 210 220 230 240 NGSSGIAVGM ATNIPPHNLS ELIDGLQALI SNPELSDSEL MTLIPGPDFP TGGQILGRSG 250 260 270 280 290 300 IRETYLTGRG SVTMRGVANI ETIEHPGRAD RDAVIITELP YQTNKAALIE RIAEMVNDKK 310 320 330 340 350 360 LEGISDIRDE SDRDGMRIVV ELRRDAYPQV VLNNLFKLTP LQSNFSAHML ALVNGEPVLL 370 380 390 400 410 420 TLRKMLQVFL DFRVDTVERR TRYFLRKAEE RDHILLGLLL ALDQLDPIIA LIRAASDTAT 430 440 450 460 470 480 ARQQLQEHHG LTEIQADAIL QMQLRRLTAL EADKIRLEHE DLVTKIANYK DILGRRERVF 490 500 510 520 530 540 GLIEDELTKL REKHCLPRRT EILDLGGGLE DIDLIANERS VVLLTETGYL KRMPVSEFEA 550 560 570 580 590 600 TSRGTRGKAG TRSQGEEAVK LFISCNDHDT LLLFSDRGVS YALPAYRVPQ CSRTAKGTPV 610 620 630 640 650 660 VQLLPIPREE AITSLLSVIS FDDDTHLLML TKGGFIKRTS LSAFSKIRSN GLIAIGLEEG 670 680 690 700 710 720 DALTWVRLAV PGDSVLIASR AGMTIHFRLC DEELRPLGRT ARGVRAMNLR GGDSLVSMDV 730 740 750 760 770 780 LPVELADQVA KSLEDDQDES GETVVVSDGP WVLVASASGL GKRVPVNQFR LQKRAGMGLR 790 800 810 820 830 840 AIKFRREGDE LVGLRVLGYG EELLLVSERG VIVRTSADKI PQQSRAATGV RLQRLDAGDR 850 860 870 LSEVVLVPPD SEDQDQPDDR SDPSEVAGVD DAPSS

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX548175 Genomic DNA. Translation: CAE21299.1.
RefSeq	NP_894955.1. NC_005071.1.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortal	Q7V6M9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7V6M9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1729594.
GenomeReviews	Gene locus PMT_1124 in contig BX548175_GR.
KEGG	pmt:PMT1124.
NMPDR	fig|74547.1.peg.1122.
PATRIC	23010639. VBIProMar135351_1468.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
PhylomeDB	Q7V6M9.
ProtClustDB	PRK05560.
Enzyme and pathway databases
BioCyc	PMAR74547:PMT1124-MONOMER.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q7V6M9_PROMM

Accession

Primary (citable) accession number: Q7V6M9

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)