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Q7V606

- PNP_PROMM

UniProt

Q7V606 - PNP_PROMM

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi497 – 4971MagnesiumUniRule annotation
Metal bindingi503 – 5031MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:PMT_1377
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Polyribonucleotide nucleotidyltransferasePRO_0000329769Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT1377.

Structurei

3D structure databases

ProteinModelPortaliQ7V606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini564 – 62360KHUniRule annotationAdd
BLAST
Domaini633 – 70169S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V606-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGQTQSISF DGREIRLTTG RYAPQAGGSV MMECGDTAVL VTATRSTGRE
60 70 80 90 100
GIDFLPLICD YEERLYAAGR IPGSFMRREG RPPERATLIA RLIDRPMRPL
110 120 130 140 150
FPSWMRDDLQ IVATCLSLDE RVPADVLAVT GASMATLLAS IPFQGPMAAV
160 170 180 190 200
RVGLLGDDFV LNPSYREIER GDLDLVVAGT PDGVVMVEAG ANQLPQGDVI
210 220 230 240 250
EAIDFGYEAV CELIKAQQTI LKDAGIKQVQ PEPPTQDQDT KLSTYLEKNC
260 270 280 290 300
SKSIGEVLKQ FEQTKAERDS KLDAIKAKTA EAIDSLKEDD AVRKSVNANS
310 320 330 340 350
KVLSNNFKAL TKKLMREQII KQGKRVDGRK LDEVRPISSA AGVLPKRVHG
360 370 380 390 400
SGLFQRGLTQ VLSTATLGTP SDAQEMDDLN PGPEKTYLHH YNFPPYSVGE
410 420 430 440 450
TRPMRSPGRR EVGHGSLAER AIIPVLPPKD SFPYVLRVVS EVLSSNGSTS
460 470 480 490 500
MGSVCGSTLA LMDAGVPLKA PVSGAAMGLI KEDAEIRILT DIQGIEDFLG
510 520 530 540 550
DMDFKVAGTK DGITALQMDM KITGLPVKTI AEAVNQARPA RIHILEKMLE
560 570 580 590 600
AIDAPRTTLS PHAPRLLSFR IDPELIGTVI GPGGRTIKGI TERTNTKIDI
610 620 630 640 650
EDGGIVTIAS HDGAAAEAAQ RIIEGLTRKV NEGEVFTGTI TRIIPIGAFV
660 670 680 690 700
EILPGKEGMI HISQLSEARV EKVDDVVKVG DQVTVRIREI DNRGRINLTL
710 720
RGVPQNGEET QSEPAPTPVA PLN
Length:723
Mass (Da):78,164
Last modified:October 1, 2003 - v1
Checksum:i343F6C402507EBA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21552.1.
RefSeqiNP_895204.1. NC_005071.1.
WP_011130745.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE21552; CAE21552; PMT_1377.
GeneIDi1728211.
KEGGipmt:PMT1377.
PATRICi23011231. VBIProMar135351_1762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21552.1 .
RefSeqi NP_895204.1. NC_005071.1.
WP_011130745.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT1377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE21552 ; CAE21552 ; PMT_1377 .
GeneIDi 1728211.
KEGGi pmt:PMT1377.
PATRICi 23011231. VBIProMar135351_1762.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiPNP_PROMM
AccessioniPrimary (citable) accession number: Q7V606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3