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Q7V5X6

- LPXB_PROMM

UniProt

Q7V5X6 - LPXB_PROMM

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:PMT_1409
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Lipid-A-disaccharide synthasePRO_0000190176Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT1409.

Structurei

3D structure databases

ProteinModelPortaliQ7V5X6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V5X6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRLLISTGE VSGDLQGSLL IQALQREVER RSLPLELMAL GGPRMQASGA
60 70 80 90 100
ELLADTAPMG AIGLWEALPL VLPTLRLQSR VDHVLKQRPP DAVVLIDYMG
110 120 130 140 150
ANVRLGHKLR RWFPRVPIIY YIAPQEWAWR FGDGGTTQLL SFTDRILAIF
160 170 180 190 200
PVEAEFYSQR GAKVTWVGHP LLDTVSVLPD RQQARERLGL KPGQRLLLLL
210 220 230 240 250
PASRQQELRY LMPTLAKAAA LLQQRDQSLE VIVPAGLASF EKSLQEALEA
260 270 280 290 300
AAVRGRVLSA QQADELKPML YAAADLALGK SGTVNMEMAL RGVPQVVGYK
310 320 330 340 350
VSRITAFVAR HFLRFRVEHI SPVNLLLKER LVPELLQDEL TAEALVQAAI
360 370 380 390
PLLEDPAQRN EMLEGYRRLR QTLGVPGVTD RAAKEILDLT KT
Length:392
Mass (Da):43,534
Last modified:October 1, 2003 - v1
Checksum:i19C05F7DC3E23062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21584.1.
RefSeqiNP_895236.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE21584; CAE21584; PMT_1409.
GeneIDi1728149.
KEGGipmt:PMT1409.
PATRICi23011329. VBIProMar135351_1809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21584.1 .
RefSeqi NP_895236.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V5X6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT1409.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE21584 ; CAE21584 ; PMT_1409 .
GeneIDi 1728149.
KEGGi pmt:PMT1409.
PATRICi 23011329. VBIProMar135351_1809.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiLPXB_PROMM
AccessioniPrimary (citable) accession number: Q7V5X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3