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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421NADUniRule annotation
Binding sitei204 – 2041NADUniRule annotation
Binding sitei227 – 2271NADUniRule annotation
Binding sitei250 – 2501SubstrateUniRule annotation
Metal bindingi272 – 2721ZincUniRule annotation
Binding sitei272 – 2721SubstrateUniRule annotation
Metal bindingi275 – 2751ZincUniRule annotation
Binding sitei275 – 2751SubstrateUniRule annotation
Active sitei340 – 3401Proton acceptorUniRule annotation
Active sitei341 – 3411Proton acceptorUniRule annotation
Binding sitei341 – 3411SubstrateUniRule annotation
Metal bindingi374 – 3741ZincUniRule annotation
Binding sitei374 – 3741SubstrateUniRule annotation
Binding sitei428 – 4281SubstrateUniRule annotation
Metal bindingi433 – 4331ZincUniRule annotation
Binding sitei433 – 4331SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PMT_1510
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenasePRO_0000135814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT1510.

Structurei

3D structure databases

ProteinModelPortaliQ7V5N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V5N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSGQAESE TPSTLIHCVR DRQQAKRELE RLANRSTGNS QKQAMATVED
60 70 80 90 100
ILDTVRSQGD QALITLTERF DGFRPEPLTV APEELEDAWR KTPQKLQSAL
110 120 130 140 150
ELAYRRIQDF HQHQRPNDLM VQGIHGEQLG RRWRPVQKAG IYIPGGRAAY
160 170 180 190 200
PSTVLMNAVP AQVAGVEQLV MTSPAGRDGQ INRTVLAAAH LAGIREVLRL
210 220 230 240 250
GGAQAIAALA FGTETVPKVD VISGPGNLYV TLAKKAVYGQ VGIDSLAGPS
260 270 280 290 300
EVLVIADQSA RVEQVAADLL AQSEHDPLAA AVLLTTEASL AEQLPSHLEA
310 320 330 340 350
QLKGHPREQI CRASLSNWGL VVICESLERC AQLSDHFAPE HLELLVEHPH
360 370 380 390 400
AIADCIKNAG AIFIGPWTPE AVGDYLAGPN HTLPTCGTAR FSGALSVETF
410 420 430 440
LRHTSLIEFN RSALEATANA VRELASSEGL HSHAESVRIR FE
Length:442
Mass (Da):47,869
Last modified:September 30, 2003 - v1
Checksum:iD3A84859545793C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21685.1.
RefSeqiNP_895337.1. NC_005071.1.
WP_011130878.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE21685; CAE21685; PMT_1510.
KEGGipmt:PMT1510.
PATRICi23011587. VBIProMar135351_1937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21685.1.
RefSeqiNP_895337.1. NC_005071.1.
WP_011130878.1. NC_005071.1.

3D structure databases

ProteinModelPortaliQ7V5N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi74547.PMT1510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE21685; CAE21685; PMT_1510.
KEGGipmt:PMT1510.
PATRICi23011587. VBIProMar135351_1937.

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiHISX_PROMM
AccessioniPrimary (citable) accession number: Q7V5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2004
Last sequence update: September 30, 2003
Last modified: March 31, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.