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Q7V5N9

- HISX_PROMM

UniProt

Q7V5N9 - HISX_PROMM

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421NADUniRule annotation
Binding sitei204 – 2041NADUniRule annotation
Binding sitei227 – 2271NADUniRule annotation
Binding sitei250 – 2501SubstrateUniRule annotation
Metal bindingi272 – 2721ZincUniRule annotation
Binding sitei272 – 2721SubstrateUniRule annotation
Metal bindingi275 – 2751ZincUniRule annotation
Binding sitei275 – 2751SubstrateUniRule annotation
Active sitei340 – 3401Proton acceptorUniRule annotation
Active sitei341 – 3411Proton acceptorUniRule annotation
Binding sitei341 – 3411SubstrateUniRule annotation
Metal bindingi374 – 3741ZincUniRule annotation
Binding sitei374 – 3741SubstrateUniRule annotation
Binding sitei428 – 4281SubstrateUniRule annotation
Metal bindingi433 – 4331ZincUniRule annotation
Binding sitei433 – 4331SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PMT_1510
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenasePRO_0000135814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT1510.

Structurei

3D structure databases

ProteinModelPortaliQ7V5N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V5N9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQSGQAESE TPSTLIHCVR DRQQAKRELE RLANRSTGNS QKQAMATVED
60 70 80 90 100
ILDTVRSQGD QALITLTERF DGFRPEPLTV APEELEDAWR KTPQKLQSAL
110 120 130 140 150
ELAYRRIQDF HQHQRPNDLM VQGIHGEQLG RRWRPVQKAG IYIPGGRAAY
160 170 180 190 200
PSTVLMNAVP AQVAGVEQLV MTSPAGRDGQ INRTVLAAAH LAGIREVLRL
210 220 230 240 250
GGAQAIAALA FGTETVPKVD VISGPGNLYV TLAKKAVYGQ VGIDSLAGPS
260 270 280 290 300
EVLVIADQSA RVEQVAADLL AQSEHDPLAA AVLLTTEASL AEQLPSHLEA
310 320 330 340 350
QLKGHPREQI CRASLSNWGL VVICESLERC AQLSDHFAPE HLELLVEHPH
360 370 380 390 400
AIADCIKNAG AIFIGPWTPE AVGDYLAGPN HTLPTCGTAR FSGALSVETF
410 420 430 440
LRHTSLIEFN RSALEATANA VRELASSEGL HSHAESVRIR FE
Length:442
Mass (Da):47,869
Last modified:October 1, 2003 - v1
Checksum:iD3A84859545793C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE21685.1.
RefSeqiNP_895337.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE21685; CAE21685; PMT_1510.
GeneIDi1728529.
KEGGipmt:PMT1510.
PATRICi23011587. VBIProMar135351_1937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE21685.1 .
RefSeqi NP_895337.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V5N9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT1510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE21685 ; CAE21685 ; PMT_1510 .
GeneIDi 1728529.
KEGGi pmt:PMT1510.
PATRICi 23011587. VBIProMar135351_1937.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiHISX_PROMM
AccessioniPrimary (citable) accession number: Q7V5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3