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Q7V5N9

- HISX_PROMM

UniProt

Q7V5N9 - HISX_PROMM

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Protein

Histidinol dehydrogenase

Gene
hisD, PMT_1510
Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei142 – 1421NAD By similarity
Binding sitei204 – 2041NAD By similarity
Binding sitei227 – 2271NAD By similarity
Binding sitei250 – 2501Substrate By similarity
Metal bindingi272 – 2721Zinc By similarity
Binding sitei272 – 2721Substrate By similarity
Metal bindingi275 – 2751Zinc By similarity
Binding sitei275 – 2751Substrate By similarity
Active sitei340 – 3401Proton acceptor By similarity
Active sitei341 – 3411Proton acceptor By similarity
Binding sitei341 – 3411Substrate By similarity
Metal bindingi374 – 3741Zinc By similarity
Binding sitei374 – 3741Substrate By similarity
Binding sitei428 – 4281Substrate By similarity
Metal bindingi433 – 4331Zinc By similarity
Binding sitei433 – 4331Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PMT_1510
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenaseUniRule annotationPRO_0000135814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT1510.

Structurei

3D structure databases

ProteinModelPortaliQ7V5N9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V5N9-1 [UniParc]FASTAAdd to Basket

« Hide

MTQSGQAESE TPSTLIHCVR DRQQAKRELE RLANRSTGNS QKQAMATVED    50
ILDTVRSQGD QALITLTERF DGFRPEPLTV APEELEDAWR KTPQKLQSAL 100
ELAYRRIQDF HQHQRPNDLM VQGIHGEQLG RRWRPVQKAG IYIPGGRAAY 150
PSTVLMNAVP AQVAGVEQLV MTSPAGRDGQ INRTVLAAAH LAGIREVLRL 200
GGAQAIAALA FGTETVPKVD VISGPGNLYV TLAKKAVYGQ VGIDSLAGPS 250
EVLVIADQSA RVEQVAADLL AQSEHDPLAA AVLLTTEASL AEQLPSHLEA 300
QLKGHPREQI CRASLSNWGL VVICESLERC AQLSDHFAPE HLELLVEHPH 350
AIADCIKNAG AIFIGPWTPE AVGDYLAGPN HTLPTCGTAR FSGALSVETF 400
LRHTSLIEFN RSALEATANA VRELASSEGL HSHAESVRIR FE 442
Length:442
Mass (Da):47,869
Last modified:October 1, 2003 - v1
Checksum:iD3A84859545793C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE21685.1.
RefSeqiNP_895337.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE21685; CAE21685; PMT_1510.
GeneIDi1728529.
KEGGipmt:PMT1510.
PATRICi23011587. VBIProMar135351_1937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE21685.1 .
RefSeqi NP_895337.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V5N9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT1510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE21685 ; CAE21685 ; PMT_1510 .
GeneIDi 1728529.
KEGGi pmt:PMT1510.
PATRICi 23011587. VBIProMar135351_1937.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiHISX_PROMM
AccessioniPrimary (citable) accession number: Q7V5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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