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Q7V5N9

- HISX_PROMM

UniProt

Q7V5N9 - HISX_PROMM

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei142 – 1421NADUniRule annotation
    Binding sitei204 – 2041NADUniRule annotation
    Binding sitei227 – 2271NADUniRule annotation
    Binding sitei250 – 2501SubstrateUniRule annotation
    Metal bindingi272 – 2721ZincUniRule annotation
    Binding sitei272 – 2721SubstrateUniRule annotation
    Metal bindingi275 – 2751ZincUniRule annotation
    Binding sitei275 – 2751SubstrateUniRule annotation
    Active sitei340 – 3401Proton acceptorUniRule annotation
    Active sitei341 – 3411Proton acceptorUniRule annotation
    Binding sitei341 – 3411SubstrateUniRule annotation
    Metal bindingi374 – 3741ZincUniRule annotation
    Binding sitei374 – 3741SubstrateUniRule annotation
    Binding sitei428 – 4281SubstrateUniRule annotation
    Metal bindingi433 – 4331ZincUniRule annotation
    Binding sitei433 – 4331SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:PMT_1510
    OrganismiProchlorococcus marinus (strain MIT 9313)
    Taxonomic identifieri74547 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001423: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Histidinol dehydrogenasePRO_0000135814Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi74547.PMT1510.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V5N9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7V5N9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQSGQAESE TPSTLIHCVR DRQQAKRELE RLANRSTGNS QKQAMATVED    50
    ILDTVRSQGD QALITLTERF DGFRPEPLTV APEELEDAWR KTPQKLQSAL 100
    ELAYRRIQDF HQHQRPNDLM VQGIHGEQLG RRWRPVQKAG IYIPGGRAAY 150
    PSTVLMNAVP AQVAGVEQLV MTSPAGRDGQ INRTVLAAAH LAGIREVLRL 200
    GGAQAIAALA FGTETVPKVD VISGPGNLYV TLAKKAVYGQ VGIDSLAGPS 250
    EVLVIADQSA RVEQVAADLL AQSEHDPLAA AVLLTTEASL AEQLPSHLEA 300
    QLKGHPREQI CRASLSNWGL VVICESLERC AQLSDHFAPE HLELLVEHPH 350
    AIADCIKNAG AIFIGPWTPE AVGDYLAGPN HTLPTCGTAR FSGALSVETF 400
    LRHTSLIEFN RSALEATANA VRELASSEGL HSHAESVRIR FE 442
    Length:442
    Mass (Da):47,869
    Last modified:October 1, 2003 - v1
    Checksum:iD3A84859545793C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE21685.1.
    RefSeqiNP_895337.1. NC_005071.1.

    Genome annotation databases

    EnsemblBacteriaiCAE21685; CAE21685; PMT_1510.
    GeneIDi1728529.
    KEGGipmt:PMT1510.
    PATRICi23011587. VBIProMar135351_1937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE21685.1 .
    RefSeqi NP_895337.1. NC_005071.1.

    3D structure databases

    ProteinModelPortali Q7V5N9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74547.PMT1510.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE21685 ; CAE21685 ; PMT_1510 .
    GeneIDi 1728529.
    KEGGi pmt:PMT1510.
    PATRICi 23011587. VBIProMar135351_1937.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9313.

    Entry informationi

    Entry nameiHISX_PROMM
    AccessioniPrimary (citable) accession number: Q7V5N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3