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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei25Proton donorUniRule annotation1
Binding sitei53Beta-alanineUniRule annotation1
Binding sitei53PantoateUniRule annotation1
Binding sitei148PantoateUniRule annotation1
Binding sitei171ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25ATPUniRule annotation8
Nucleotide bindingi142 – 145ATPUniRule annotation4
Nucleotide bindingi179 – 182ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Ligase, Multifunctional enzyme, Transferase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:PMT_1689
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001423 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397911 – 505Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST505

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT1689.

Structurei

3D structure databases

ProteinModelPortaliQ7V583.
SMRiQ7V583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 268Pantoate--beta-alanine ligaseUniRule annotationAdd BLAST268
Regioni269 – 505Cytidylate kinaseUniRule annotationAdd BLAST237

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
COG0414. LUCA.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiPOG091H00RB.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
MF_00158. PanC. 1 hit.
MF_01349. PanCY. 1 hit.
InterProiView protein in InterPro
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQWRKHQQS SVHFVPTMGA LHRGHGQLIK SVHGFGRLQP AAVLVSVFVN
60 70 80 90 100
PLQFGPAEDF DSYPRDLEAD CELASRSGAS ALWAPSVDQV FPGGASSHFR
110 120 130 140 150
IQVPSHLQAH LCGASRPGHF DGVVTVVARL LALVRPEVLV LGEKDWQQLV
160 170 180 190 200
ILRHLVAQLG LPVRVHGIAT VRDDDGLACS SRNRYLMTQQ RQQALALPQL
210 220 230 240 250
LARAARESQD GRAVDLAGLR CAWEQLGLEV EYVEKVDAFN LQPLHAGRKL
260 270 280 290 300
CLLAAAVRCG ETRLIDHTFL MSRQPIVAID GPAGAGKSTV TRAFAERLGL
310 320 330 340 350
LYLDTGAMYR AVTWLTQQHD VDPHDPVAVK TILENLELEL EPSQSGAQTV
360 370 380 390 400
RINGHDVTEA IRSPEVTSSV SVVAAHGCVR KALTAQQQRM GVRGGLVAEG
410 420 430 440 450
RDIGTAVFPD AELKVFLTAS PAERARRRAL DLDNRGFPVP DLAELETQIE
460 470 480 490 500
ERDRMDSTRE VAPLRQAEDA TELISDGMTI EEVIETLIDL FRVQVPEEVW

PTAGR
Length:505
Mass (Da):55,363
Last modified:October 1, 2003 - v1
Checksum:iBFE647766ADDC12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE21864.1.

Genome annotation databases

EnsemblBacteriaiCAE21864; CAE21864; PMT_1689.
KEGGipmt:PMT_1689.

Similar proteinsi

Entry informationi

Entry nameiPANCY_PROMM
AccessioniPrimary (citable) accession number: Q7V583
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2003
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome