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Q7V4L5 (Q7V4L5_PROMM) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Name:icd EMBL CAE22109.1
Ordered Locus Names:PMT_1935 EMBL CAE22109.1
OrganismProchlorococcus marinus (strain MIT 9313) [Complete proteome] [HAMAP] EMBL CAE22109.1
Taxonomic identifier74547 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
Q7V4L5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D6DBD6364F78E897

FASTA47451,961
        10         20         30         40         50         60 
MAQFEKLSPP SQGTAIRFVN GQPVIPNEPI IPFIRGDGTG VDIWPATQRV LDAAVTKAYQ 

        70         80         90        100        110        120 
GVRRIEWFKV YAGDEACDLY GTYQYLPEDT LEAIRTYGVA IKGPLTTPIG GGIRSLNVAL 

       130        140        150        160        170        180 
RQIFDLYSCV RPCRYYKGTP SPHKRPQDLD VIVYRENTED IYMGVEWEAD DPVGKTLREH 

       190        200        210        220        230        240 
LNTVVIPANG KLGKRQIPEG SGIGIKPVSK HGSQRHIRKA IQHALRLKGD KRHVTLVHKG 

       250        260        270        280        290        300 
NIMKFTEGAF RDWGYELATS EFRDVCITER ESWILGNLEN DPQLSIQANA RMIEPGYDSL 

       310        320        330        340        350        360 
TPERKASIDA EVHGVLDAIG TSHGNGQWKA MVLVDDRIAD SIFQQIQTRP QEYSILATLN 

       370        380        390        400        410        420 
LNGDYISDAA AAMVGGLGMA PGANIGENAA IFEATHGTAP KHAGLDRINP GSVILSGVMM 

       430        440        450        460        470 
LEFLGWQEAA DLITKGLSAA IANQQVTYDL ARLMDPPVDP VSCSGFSEAV ISHF 

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References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9313.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX548175 Genomic DNA. Translation: CAE22109.1.
RefSeqNP_895760.1. NC_005071.1.

3D structure databases

ProteinModelPortalQ7V4L5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING74547.PMT1935.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE22109; CAE22109; PMT_1935.
GeneID1729181.
KEGGpmt:PMT1935.
PATRIC23012687. VBIProMar135351_2469.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
KOK00031.
OMAFRDWGYE.
OrthoDBEOG6SNDTP.
ProtClustDBPRK07362.

Family and domain databases

Gene3D3.40.718.10. 2 hits.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7V4L5_PROMM
AccessionPrimary (citable) accession number: Q7V4L5
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 13, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)