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Q7V4L5

- Q7V4L5_PROMM

UniProt

Q7V4L5 - Q7V4L5_PROMM

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:PMT_1935Imported
    OrganismiProchlorococcus marinus (strain MIT 9313)Imported
    Taxonomic identifieri74547 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001423: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi74547.PMT1935.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V4L5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 2 hits.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7V4L5-1 [UniParc]FASTAAdd to Basket

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    MAQFEKLSPP SQGTAIRFVN GQPVIPNEPI IPFIRGDGTG VDIWPATQRV    50
    LDAAVTKAYQ GVRRIEWFKV YAGDEACDLY GTYQYLPEDT LEAIRTYGVA 100
    IKGPLTTPIG GGIRSLNVAL RQIFDLYSCV RPCRYYKGTP SPHKRPQDLD 150
    VIVYRENTED IYMGVEWEAD DPVGKTLREH LNTVVIPANG KLGKRQIPEG 200
    SGIGIKPVSK HGSQRHIRKA IQHALRLKGD KRHVTLVHKG NIMKFTEGAF 250
    RDWGYELATS EFRDVCITER ESWILGNLEN DPQLSIQANA RMIEPGYDSL 300
    TPERKASIDA EVHGVLDAIG TSHGNGQWKA MVLVDDRIAD SIFQQIQTRP 350
    QEYSILATLN LNGDYISDAA AAMVGGLGMA PGANIGENAA IFEATHGTAP 400
    KHAGLDRINP GSVILSGVMM LEFLGWQEAA DLITKGLSAA IANQQVTYDL 450
    ARLMDPPVDP VSCSGFSEAV ISHF 474
    Length:474
    Mass (Da):51,961
    Last modified:October 1, 2003 - v1
    Checksum:iD6DBD6364F78E897
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE22109.1.
    RefSeqiNP_895760.1. NC_005071.1.

    Genome annotation databases

    EnsemblBacteriaiCAE22109; CAE22109; PMT_1935.
    GeneIDi1729181.
    KEGGipmt:PMT1935.
    PATRICi23012687. VBIProMar135351_2469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE22109.1 .
    RefSeqi NP_895760.1. NC_005071.1.

    3D structure databases

    ProteinModelPortali Q7V4L5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74547.PMT1935.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE22109 ; CAE22109 ; PMT_1935 .
    GeneIDi 1729181.
    KEGGi pmt:PMT1935.
    PATRICi 23012687. VBIProMar135351_2469.

    Phylogenomic databases

    eggNOGi COG0538.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Family and domain databases

    Gene3Di 3.40.718.10. 2 hits.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9313Imported.

    Entry informationi

    Entry nameiQ7V4L5_PROMM
    AccessioniPrimary (citable) accession number: Q7V4L5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3