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Q7V4D8

- NADK2_PROMM

UniProt

Q7V4D8 - NADK2_PROMM

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Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptorUniRule annotation
Binding sitei189 – 1891NADUniRule annotation
Binding sitei191 – 1911NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 682NADUniRule annotation
Nucleotide bindingi159 – 1602NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:PMT_2016
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315NAD kinase 2PRO_0000229671Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74547.PMT2016.

Structurei

3D structure databases

ProteinModelPortaliQ7V4D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V4D8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLDLVWVIY RAGSHSAHRE ACCCVDELQA LGVKVVMAMS GVTANPFPDL
60 70 80 90 100
LASEAGLPDL AVVLGGDGTV LGAARHLAVH DVPILSFNVG GHLGFLTHER
110 120 130 140 150
CLLDGGQLWQ RLLQDNFALE RRMMLQAAVD SRSPAERTAR PTASLQDLNG
160 170 180 190 200
TKALHWALND FYMRPYRDDV SPTCTLELEI DGEVVDHYRG DGLILATPTG
210 220 230 240 250
STGYSMASGG PILHPGIDAI IVSPICPMSL SSRPVIVPPA SRLVIGLLGE
260 270 280 290 300
NTRRVKLWKD GASGALLEPG QCCVVQRARH HALMVVLEQS PSYYRTLTHK
310
LHWAGSLLNN QPSPS
Length:315
Mass (Da):34,059
Last modified:October 1, 2003 - v1
Checksum:iDEFC542D8A8F373E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE22190.1.
RefSeqiNP_895841.1. NC_005071.1.
WP_011131381.1. NC_005071.1.

Genome annotation databases

EnsemblBacteriaiCAE22190; CAE22190; PMT_2016.
GeneIDi1728997.
KEGGipmt:PMT2016.
PATRICi23012871. VBIProMar135351_2559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548175 Genomic DNA. Translation: CAE22190.1 .
RefSeqi NP_895841.1. NC_005071.1.
WP_011131381.1. NC_005071.1.

3D structure databases

ProteinModelPortali Q7V4D8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74547.PMT2016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE22190 ; CAE22190 ; PMT_2016 .
GeneIDi 1728997.
KEGGi pmt:PMT2016.
PATRICi 23012871. VBIProMar135351_2559.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiNADK2_PROMM
AccessioniPrimary (citable) accession number: Q7V4D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3