Reviewed, UniProtKB/Swiss-Prot Q7V4D8 (PPNK2_PROMM)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 2
      Short name=Poly(P)/ATP NAD kinase 2
    EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	PMT_2016

Organism

Prochlorococcus marinus (strain MIT 9313) [Complete proteome] [HAMAP]

Taxonomic identifier

74547 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229671

Sequences

	Sequence		Length	Mass (Da)
	Q7V4D8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: DEFC542D8A8F373E	FASTA	315	34,059
	10 20 30 40 50 60 MRLDLVWVIY RAGSHSAHRE ACCCVDELQA LGVKVVMAMS GVTANPFPDL LASEAGLPDL 70 80 90 100 110 120 AVVLGGDGTV LGAARHLAVH DVPILSFNVG GHLGFLTHER CLLDGGQLWQ RLLQDNFALE 130 140 150 160 170 180 RRMMLQAAVD SRSPAERTAR PTASLQDLNG TKALHWALND FYMRPYRDDV SPTCTLELEI 190 200 210 220 230 240 DGEVVDHYRG DGLILATPTG STGYSMASGG PILHPGIDAI IVSPICPMSL SSRPVIVPPA 250 260 270 280 290 300 SRLVIGLLGE NTRRVKLWKD GASGALLEPG QCCVVQRARH HALMVVLEQS PSYYRTLTHK 310 LHWAGSLLNN QPSPS

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX548175 Genomic DNA. Translation: CAE22190.1.
RefSeq	NP_895841.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7V4D8.
Genome annotation databases
GeneID	1728997.
GenomeReviews	Gene locus PMT_2016 in contig BX548175_GR.
KEGG	pmt:PMT2016.
NMPDR	fig|74547.1.peg.2008.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7V4D8.
OMA	KLHWAGS.
Enzyme and pathway databases
BioCyc	PMAR74547:PMT2016-MON.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK2_PROMM

Accession

Primary (citable) accession number: Q7V4D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)