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Q7V411 (GCSP_PROMM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PMT_2169
OrganismProchlorococcus marinus (strain MIT 9313) [Complete proteome] [HAMAP]
Taxonomic identifier74547 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166924

Amino acid modifications

Modified residue7011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7V411 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 1D11C9D97625A1AB

FASTA962103,971
        10         20         30         40         50         60 
MRHIGPSLED QQQMLLELGH RDLQSFVAAV VPPDILETTA PSSSLPEGCG EVQAMEELRL 

        70         80         90        100        110        120 
IAAANRVRRS LIGLGYYGTA TPALIQRQVL ENPAWYTAYT PYQAEISQGR LEALFNFQTL 

       130        140        150        160        170        180 
ISELTGLPIA NASLLDEGTA AAEAMSLSFA ICKRPAAHRF LVDAEVLPQT LAVLRTRAEP 

       190        200        210        220        230        240 
LGIDLEVAEP MTFQFDAEVF GVLLQLPGRS GRLWDPTTSI QAAHEVGALA TVAIDPLAQV 

       250        260        270        280        290        300 
LLAPVAEFGA DIAVGSVQRF GVPMGFGGPH AAFFATLEIF KRQVPGRLVG QSVDAEGQPA 

       310        320        330        340        350        360 
LRLALQTREQ HIRRDKATSN ICTAQVLLAV MASFYAVHHG PDGLAAIARR VLRLRAQLER 

       370        380        390        400        410        420 
GLHQLGYPVQ SIARFDTIEV ICREAPAVHQ AAALAGFNLR VLPLGVAPEA AHGFGISFDE 

       430        440        450        460        470        480 
LSTDQELKSI LQILAEAAGQ PVPVLEDPGN PHLEELVGLP LRQRPWLQQQ VFHRYRSETE 

       490        500        510        520        530        540 
LLRYLQRLVG RDLSLVHGMI PLGSCTMKLN AAAELIPISW REFAALHPFA PQDQCQGYQR 

       550        560        570        580        590        600 
LVQDLEHWFA DITGFAGVSL QPNAGSQGEL AGLLVIRAWH HSRGEQQRDV CLIPTSAHGT 

       610        620        630        640        650        660 
NPATCVMAGL RVVPVACDAD GNVDLNDLAS KAEAHAPQLA ALMVTYPSTH GVFEPQIREI 

       670        680        690        700        710        720 
CELVHGHGGQ VYLDGANLNA QIGFCRPGTY GADVCHINLH KTFCIPHGGG GPGVGPIAVS 

       730        740        750        760        770        780 
AHLMPFLPGH PLAACGGEQG IGAISAAPWG SAGILPISWM YLRMMGAEGL RQASAVALLS 

       790        800        810        820        830        840 
ANYLAHRLHP HYPVLFRGQA GLVAHECILD LRPLKRSAGL EVDDIAKRLM DYGFHAPTVS 

       850        860        870        880        890        900 
WPVAGTVMVE PTESESLEEL NRFCDAMIAI REETAAIESG QIDPQNNPLR RAPHTLAAVT 

       910        920        930        940        950        960 
AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS RIDNAYGDRN LLCSCPSVEE LADNAVLKPP 


LV 

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References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9313.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX548175 Genomic DNA. Translation: CAE22343.1.
RefSeqNP_895993.1. NC_005071.1.

3D structure databases

ProteinModelPortalQ7V411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING74547.PMT2169.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE22343; CAE22343; PMT_2169.
GeneID1728172.
KEGGpmt:PMT2169.
PATRIC23013263. VBIProMar135351_2754.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PROMM
AccessionPrimary (citable) accession number: Q7V411
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families