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Q7V411

- GCSP_PROMM

UniProt

Q7V411 - GCSP_PROMM

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PMT_2169
    OrganismiProchlorococcus marinus (strain MIT 9313)
    Taxonomic identifieri74547 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001423: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_0000166924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei701 – 7011N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi74547.PMT2169.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V411-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHIGPSLED QQQMLLELGH RDLQSFVAAV VPPDILETTA PSSSLPEGCG    50
    EVQAMEELRL IAAANRVRRS LIGLGYYGTA TPALIQRQVL ENPAWYTAYT 100
    PYQAEISQGR LEALFNFQTL ISELTGLPIA NASLLDEGTA AAEAMSLSFA 150
    ICKRPAAHRF LVDAEVLPQT LAVLRTRAEP LGIDLEVAEP MTFQFDAEVF 200
    GVLLQLPGRS GRLWDPTTSI QAAHEVGALA TVAIDPLAQV LLAPVAEFGA 250
    DIAVGSVQRF GVPMGFGGPH AAFFATLEIF KRQVPGRLVG QSVDAEGQPA 300
    LRLALQTREQ HIRRDKATSN ICTAQVLLAV MASFYAVHHG PDGLAAIARR 350
    VLRLRAQLER GLHQLGYPVQ SIARFDTIEV ICREAPAVHQ AAALAGFNLR 400
    VLPLGVAPEA AHGFGISFDE LSTDQELKSI LQILAEAAGQ PVPVLEDPGN 450
    PHLEELVGLP LRQRPWLQQQ VFHRYRSETE LLRYLQRLVG RDLSLVHGMI 500
    PLGSCTMKLN AAAELIPISW REFAALHPFA PQDQCQGYQR LVQDLEHWFA 550
    DITGFAGVSL QPNAGSQGEL AGLLVIRAWH HSRGEQQRDV CLIPTSAHGT 600
    NPATCVMAGL RVVPVACDAD GNVDLNDLAS KAEAHAPQLA ALMVTYPSTH 650
    GVFEPQIREI CELVHGHGGQ VYLDGANLNA QIGFCRPGTY GADVCHINLH 700
    KTFCIPHGGG GPGVGPIAVS AHLMPFLPGH PLAACGGEQG IGAISAAPWG 750
    SAGILPISWM YLRMMGAEGL RQASAVALLS ANYLAHRLHP HYPVLFRGQA 800
    GLVAHECILD LRPLKRSAGL EVDDIAKRLM DYGFHAPTVS WPVAGTVMVE 850
    PTESESLEEL NRFCDAMIAI REETAAIESG QIDPQNNPLR RAPHTLAAVT 900
    AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS RIDNAYGDRN LLCSCPSVEE 950
    LADNAVLKPP LV 962
    Length:962
    Mass (Da):103,971
    Last modified:October 1, 2003 - v1
    Checksum:i1D11C9D97625A1AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE22343.1.
    RefSeqiNP_895993.1. NC_005071.1.
    WP_011131533.1. NC_005071.1.

    Genome annotation databases

    EnsemblBacteriaiCAE22343; CAE22343; PMT_2169.
    GeneIDi1728172.
    KEGGipmt:PMT2169.
    PATRICi23013263. VBIProMar135351_2754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548175 Genomic DNA. Translation: CAE22343.1 .
    RefSeqi NP_895993.1. NC_005071.1.
    WP_011131533.1. NC_005071.1.

    3D structure databases

    ProteinModelPortali Q7V411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74547.PMT2169.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE22343 ; CAE22343 ; PMT_2169 .
    GeneIDi 1728172.
    KEGGi pmt:PMT2169.
    PATRICi 23013263. VBIProMar135351_2754.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9313.

    Entry informationi

    Entry nameiGCSP_PROMM
    AccessioniPrimary (citable) accession number: Q7V411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3