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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain MIT 9313)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PMT_2169
OrganismiProchlorococcus marinus (strain MIT 9313)
Taxonomic identifieri74547 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001423 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_0000166924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei701 – 7011N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi74547.PMT2169.

Structurei

3D structure databases

ProteinModelPortaliQ7V411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHIGPSLED QQQMLLELGH RDLQSFVAAV VPPDILETTA PSSSLPEGCG
60 70 80 90 100
EVQAMEELRL IAAANRVRRS LIGLGYYGTA TPALIQRQVL ENPAWYTAYT
110 120 130 140 150
PYQAEISQGR LEALFNFQTL ISELTGLPIA NASLLDEGTA AAEAMSLSFA
160 170 180 190 200
ICKRPAAHRF LVDAEVLPQT LAVLRTRAEP LGIDLEVAEP MTFQFDAEVF
210 220 230 240 250
GVLLQLPGRS GRLWDPTTSI QAAHEVGALA TVAIDPLAQV LLAPVAEFGA
260 270 280 290 300
DIAVGSVQRF GVPMGFGGPH AAFFATLEIF KRQVPGRLVG QSVDAEGQPA
310 320 330 340 350
LRLALQTREQ HIRRDKATSN ICTAQVLLAV MASFYAVHHG PDGLAAIARR
360 370 380 390 400
VLRLRAQLER GLHQLGYPVQ SIARFDTIEV ICREAPAVHQ AAALAGFNLR
410 420 430 440 450
VLPLGVAPEA AHGFGISFDE LSTDQELKSI LQILAEAAGQ PVPVLEDPGN
460 470 480 490 500
PHLEELVGLP LRQRPWLQQQ VFHRYRSETE LLRYLQRLVG RDLSLVHGMI
510 520 530 540 550
PLGSCTMKLN AAAELIPISW REFAALHPFA PQDQCQGYQR LVQDLEHWFA
560 570 580 590 600
DITGFAGVSL QPNAGSQGEL AGLLVIRAWH HSRGEQQRDV CLIPTSAHGT
610 620 630 640 650
NPATCVMAGL RVVPVACDAD GNVDLNDLAS KAEAHAPQLA ALMVTYPSTH
660 670 680 690 700
GVFEPQIREI CELVHGHGGQ VYLDGANLNA QIGFCRPGTY GADVCHINLH
710 720 730 740 750
KTFCIPHGGG GPGVGPIAVS AHLMPFLPGH PLAACGGEQG IGAISAAPWG
760 770 780 790 800
SAGILPISWM YLRMMGAEGL RQASAVALLS ANYLAHRLHP HYPVLFRGQA
810 820 830 840 850
GLVAHECILD LRPLKRSAGL EVDDIAKRLM DYGFHAPTVS WPVAGTVMVE
860 870 880 890 900
PTESESLEEL NRFCDAMIAI REETAAIESG QIDPQNNPLR RAPHTLAAVT
910 920 930 940 950
AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS RIDNAYGDRN LLCSCPSVEE
960
LADNAVLKPP LV
Length:962
Mass (Da):103,971
Last modified:October 1, 2003 - v1
Checksum:i1D11C9D97625A1AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE22343.1.

Genome annotation databases

EnsemblBacteriaiCAE22343; CAE22343; PMT_2169.
KEGGipmt:PMT2169.
PATRICi23013263. VBIProMar135351_2754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548175 Genomic DNA. Translation: CAE22343.1.

3D structure databases

ProteinModelPortaliQ7V411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi74547.PMT2169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE22343; CAE22343; PMT_2169.
KEGGipmt:PMT2169.
PATRICi23013263. VBIProMar135351_2754.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9313.

Entry informationi

Entry nameiGCSP_PROMM
AccessioniPrimary (citable) accession number: Q7V411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.