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Q7V3M9

- SPEA_PROMP

UniProt

Q7V3M9 - SPEA_PROMP

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-45-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:PMM0045
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Biosynthetic arginine decarboxylasePRO_0000149970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM0045.

Structurei

3D structure databases

ProteinModelPortaliQ7V3M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni291 – 30111Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiANIRDIH.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V3M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDFDTKKLN KKWTIEDSIS TYGIDKWGEK YFSINSEGNI SISPDNKSQK
60 70 80 90 100
KIDLFKLVKE FKSREINTPL IIRFNDILKD RIAELNNAFS QAIETYDYKN
110 120 130 140 150
IYKGVFPIKC NQQRNVLEKI IEYGDRWNFG LEVGSKSELL IGLSILENQK
160 170 180 190 200
SLLICNGYKD KKYIETAILA RKLGKHPIIV IEQRDEVKRI IEAVKDLKAT
210 220 230 240 250
PILGIRSKLS SKSSGRWSKS VGDNSKFGLS IPEIMLTIKE LKEANLINEM
260 270 280 290 300
MLLHFHVGSQ ISDISVIKDA LQEASQIFVE LSKLGAPMKY IDVGGGLGID
310 320 330 340 350
FDGTKMSSNT STNYSLQNYA NDVIATVKDS CEVNNIQHPI IISESGRAII
360 370 380 390 400
SHCSVLIFNI LGTSHVSSQV KVSDQKKQSL IITNLIETLN QIKNLRDKKE
410 420 430 440 450
DLSEIIELWN DAKKFKEDCL VAFRLGFICL EERAYAEELT WACAKEIANQ
460 470 480 490 500
LENNEIIHPD LSEITDTLAS TYYANLSVFK SIPDTWAINQ VFPIIPIHRH
510 520 530 540 550
LEEPFCKGHF ADLTCDSDGK LNNFIDNGKI KSLLNLHPPE KNNDYLIGIF
560 570 580 590 600
MAGAYQEALG NFHNLFGNTN VIHIDINEDN SYKIKNIIKE NSKSEILELL
610 620 630 640
DYSSDNLVES IRVNTESAIN NKTLTIQEAR KLIDQIETSL RKSSYLSE
Length:648
Mass (Da):73,425
Last modified:October 1, 2003 - v1
Checksum:iE7878AB68E181CCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE18504.1.
RefSeqiNP_892166.1. NC_005072.1.
WP_011131683.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE18504; CAE18504; PMM0045.
GeneIDi1726342.
KEGGipmm:PMM0045.
PATRICi23030720. VBIProMar68066_0046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE18504.1 .
RefSeqi NP_892166.1. NC_005072.1.
WP_011131683.1. NC_005072.1.

3D structure databases

ProteinModelPortali Q7V3M9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59919.PMM0045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE18504 ; CAE18504 ; PMM0045 .
GeneIDi 1726342.
KEGGi pmm:PMM0045.
PATRICi 23030720. VBIProMar68066_0046.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi ANIRDIH.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

BioCyci PMAR59919:GJMQ-45-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiSPEA_PROMP
AccessioniPrimary (citable) accession number: Q7V3M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3