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Q7V3C2

- NADK1_PROMP

UniProt

Q7V3C2 - NADK1_PROMP

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Protein
NAD kinase 1
Gene
nadK1, PMM0156
Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Proton acceptor By similarity
Binding sitei67 – 671NAD By similarity
Binding sitei173 – 1731NAD By similarity
Binding sitei175 – 1751NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NAD By similarity
Nucleotide bindingi143 – 1442NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 1 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 1
Gene namesi
Name:nadK1
Ordered Locus Names:PMM0156
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299NAD kinase 1UniRule annotation
PRO_0000229674Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM0156.

Structurei

3D structure databases

ProteinModelPortaliQ7V3C2.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiKLHWAGS.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V3C2-1 [UniParc]FASTAAdd to Basket

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MLIIYRSNSL TAKEASIFCN KTLKERNIKS KRIESDFDNN QLENYFYNLA    50
ALPDLVIVLG GDGTVLKSAN ALVNYDIPIL SFNIGGNLGF LTQEKDFLFD 100
QSFIKILEKE EFIIDFRNRL HCDVYSNEKN RERKILKSYD ALNDFYFKSV 150
EEDISPTNQI QIEIDNEKVN EYKGDGLIIS SSTGSTAYSM AAGGPIVHPS 200
INAFVINPIC PMSLASRPII IPDTSKVVIR VVQKNKREIK LWKDGSKCMT 250
IKENDYCEIN KVTKPCKMIK FNKSISYYIT LIKKLDWKGD LSLKNNQNN 299
Length:299
Mass (Da):34,128
Last modified:October 1, 2003 - v1
Checksum:i41F28B70D7F5244E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE18615.1.
RefSeqiNP_892277.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE18615; CAE18615; PMM0156.
GeneIDi1726207.
KEGGipmm:PMM0156.
PATRICi23030958. VBIProMar68066_0163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE18615.1 .
RefSeqi NP_892277.1. NC_005072.1.

3D structure databases

ProteinModelPortali Q7V3C2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59919.PMM0156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE18615 ; CAE18615 ; PMM0156 .
GeneIDi 1726207.
KEGGi pmm:PMM0156.
PATRICi 23030958. VBIProMar68066_0163.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi KLHWAGS.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PMAR59919:GJMQ-160-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiNADK1_PROMP
AccessioniPrimary (citable) accession number: Q7V3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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