Q7V2Q2 (MQO_PROMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	PMM0419

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]

Taxonomic identifier

59919 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.
Sequence caution	The sequence CAE18878.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_0000128728

Sequences

	Sequence		Length	Mass (Da)
	Q7V2Q2 [UniParc]. Last modified December 15, 2003. Version 2. Checksum: 02AE5FDD80F83287	FASTA	497	55,614
	10 20 30 40 50 60 MTSKNILNKN NCYDAILVGA GIMSGTLALL ITEILPTIKI LIIEKLNKPG SESTGAFNNA 70 80 90 100 110 120 GTGHAANCEL NYTPVDENGD LQIDKALFIN RSFENSMSLW ASLYSKGKID IKKFLKFIPH 130 140 150 160 170 180 ISFVTGTENI SFLKKRFKAM SKYPEFADME FSSSFNQIKS WAPLITTCRD PLDKVAATRI 190 200 210 220 230 240 KRGTDINFQA LTREYLTYIS KNKNVEIFYN TELIDLKKTD KKQWKLKVRS LGKIVSLNTS 250 260 270 280 290 300 YVFLGAGGKT INFLQKSKIP EAKIYGGFPV SGKWLICEEK SLTEKHNAKV YGKADIGSPP 310 320 330 340 350 360 MSVPHLDTRW IEGKKFLLYG PFAGFTTKFL KKGSYLDLFS SIKKSNLFSM LDVGIKNNEL 370 380 390 400 410 420 INYLFSQSFK SHNSRVENLR NMMPSAEPSN WYLENAGQRV QIIKKTKDGG SLQFGTEIVN 430 440 450 460 470 480 SGDGSLSALL GASPGASTAV SIMIEVLKKS CLFNADKFEL EKKLSNLLYE SEIKNESDNN 490 FLEIIKKRNN SILGFHP

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CCMP1986 / MED4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX548174 Genomic DNA. Translation: CAE18878.1. Different initiation.
RefSeq	NP_892537.2. NC_005072.1.
3D structure databases
ProteinModelPortal	Q7V2Q2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7V2Q2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1726870.
GenomeReviews	Gene locus PMM0419 in contig BX548174_GR.
KEGG	pmm:PMM0419.
NMPDR	fig|59919.1.peg.416.
PATRIC	23031590. VBIProMar68066_0467.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
HOGENOM	HBG289663.
OMA	KKWVPLM.
PhylomeDB	Q7V2Q2.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	PMAR167540:PMM0419-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_PROMP

Accession

Primary (citable) accession number: Q7V2Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	January 25, 2012
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program