Q7V2C1 (Q7V2C1_PROMP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase HAMAP MF_01374
EC=3.1.2.6 HAMAP MF_01374

Alternative name(s):
Glyoxalase II HAMAP MF_01374

Gene names

Name:	gloB HAMAP MF_01374
Ordered Locus Names:	PMM0559

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]

Taxonomic identifier

59919 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374 SAAS SAAS017782
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374 SAAS SAAS017782
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374 SAAS SAAS017782
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. HAMAP MF_01374 SAAS SAAS017782
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. HAMAP MF_01374

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01374 SAAS SAAS017782 Zinc HAMAP MF_01374 SAAS SAAS017782
Molecular function	Hydrolase HAMAP MF_01374 SAAS SAAS017782 EMBL CAE19018.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	58	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	60	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	62	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	63	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	117	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	137	1	Zinc 1 By similarity HAMAP MF_01374
	Metal binding	137	1	Zinc 2 By similarity HAMAP MF_01374
	Metal binding	175	1	Zinc 2 By similarity HAMAP MF_01374

Sequences

	Sequence		Length	Mass (Da)
	Q7V2C1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: A0AB1D3400F218E0	FASTA	246	28,543
	10 20 30 40 50 60 MEFNKEHKII GIRVLRDNII WLWKKNRSAV VIDPALSQPV KEYLKTNNLN LEAILQTHHH 70 80 90 100 110 120 SDHIGGTREL IKEWPNVKVI ASCKEKDRIP FQNSSVKDGD TLELLDEEVK VIEVIGHTRS 130 140 150 160 170 180 HIAFYINNNV PILFIGDTLF SAGCGRIFEG TYKQMYYSLK RIKSLPKNTL IYCAHEYTKS 190 200 210 220 230 240 NLLWALDLEP ENQNIKNKLI EVEKKIALKE LTIPCLLEEE MKINLFLRAD NLKGFSFLRA NKDSWV

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX548174 Genomic DNA. Translation: CAE19018.1.
RefSeq	NP_892677.1. NC_005072.1.
3D structure databases
ProteinModelPortal	Q7V2C1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7V2C1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1726060.
GenomeReviews	Gene locus PMM0559 in contig BX548174_GR.
KEGG	pmm:PMM0559.
NMPDR	fig|59919.1.peg.556.
PATRIC	23031886. VBIProMar68066_0613.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0491.
HOGENOM	HBG753931.
OMA	FLCRTDN.
PhylomeDB	Q7V2C1.
ProtClustDB	CLSK921893.
Enzyme and pathway databases
BioCyc	PMAR167540:PMM0559-MONOMER.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
TIGRFAMs	TIGR03413. GSH_gloB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q7V2C1_PROMP

Accession

Primary (citable) accession number: Q7V2C1

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)